Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221109878> ?p ?o ?g. }
- W4221109878 endingPage "191" @default.
- W4221109878 startingPage "173" @default.
- W4221109878 abstract "Importin α has been described as a nuclear protein transport receptor that enables proteins synthesized in the cytoplasm to translocate into the nucleus. Besides its function in nuclear transport, an increasing number of studies have examined its non-nuclear transport functions. In both nuclear transport and non-nuclear transport, a functional domain called the IBB domain (importin β binding domain) plays a key role in regulating importin α behavior, and is a common interacting domain for multiple binding partners. However, it is not yet fully understood how the IBB domain interacts with multiple binding partners, which leads to the switching of importin α function. In this study, we have distinguished the location and propensities of amino acids important for each function of the importin α IBB domain by mapping the biochemical/physicochemical propensities of evolutionarily conserved amino acids of the IBB domain onto the structure associated with each function. We found important residues that are universally conserved for IBB functions across species and family members, in addition to those previously known, as well as residues that are presumed to be responsible for the differences in complex-forming ability among family members and for functional switching." @default.
- W4221109878 created "2022-04-03" @default.
- W4221109878 creator A5027556590 @default.
- W4221109878 creator A5041944234 @default.
- W4221109878 creator A5076604047 @default.
- W4221109878 creator A5079151324 @default.
- W4221109878 creator A5084765225 @default.
- W4221109878 creator A5089509720 @default.
- W4221109878 creator A5090579064 @default.
- W4221109878 date "2022-01-11" @default.
- W4221109878 modified "2023-09-27" @default.
- W4221109878 title "Biochemical propensity mapping for structural and functional anatomy of importin α IBB domain" @default.
- W4221109878 cites W1505062366 @default.
- W4221109878 cites W1518431161 @default.
- W4221109878 cites W1534406401 @default.
- W4221109878 cites W1542067597 @default.
- W4221109878 cites W1589847606 @default.
- W4221109878 cites W1609104027 @default.
- W4221109878 cites W1832533614 @default.
- W4221109878 cites W1846296194 @default.
- W4221109878 cites W1870505444 @default.
- W4221109878 cites W1880934687 @default.
- W4221109878 cites W1971708920 @default.
- W4221109878 cites W1971794652 @default.
- W4221109878 cites W1975304761 @default.
- W4221109878 cites W1977845138 @default.
- W4221109878 cites W1989700964 @default.
- W4221109878 cites W1991018390 @default.
- W4221109878 cites W2003957660 @default.
- W4221109878 cites W2015642465 @default.
- W4221109878 cites W2023919356 @default.
- W4221109878 cites W2023941144 @default.
- W4221109878 cites W2030966943 @default.
- W4221109878 cites W2035146707 @default.
- W4221109878 cites W2035503835 @default.
- W4221109878 cites W2043287688 @default.
- W4221109878 cites W2048492672 @default.
- W4221109878 cites W2058651019 @default.
- W4221109878 cites W2075651068 @default.
- W4221109878 cites W2075770210 @default.
- W4221109878 cites W2078724625 @default.
- W4221109878 cites W2095615304 @default.
- W4221109878 cites W2095783710 @default.
- W4221109878 cites W2107158607 @default.
- W4221109878 cites W2111802043 @default.
- W4221109878 cites W2117742111 @default.
- W4221109878 cites W2132450592 @default.
- W4221109878 cites W2133179696 @default.
- W4221109878 cites W2134160801 @default.
- W4221109878 cites W2135428633 @default.
- W4221109878 cites W2137015675 @default.
- W4221109878 cites W2139123112 @default.
- W4221109878 cites W2156891333 @default.
- W4221109878 cites W2165964303 @default.
- W4221109878 cites W2171159525 @default.
- W4221109878 cites W2184157606 @default.
- W4221109878 cites W231956376 @default.
- W4221109878 cites W2322055506 @default.
- W4221109878 cites W2416814556 @default.
- W4221109878 cites W2543839061 @default.
- W4221109878 cites W2747261161 @default.
- W4221109878 cites W2799524357 @default.
- W4221109878 cites W2804822363 @default.
- W4221109878 cites W2883043162 @default.
- W4221109878 cites W2885129214 @default.
- W4221109878 cites W2981510227 @default.
- W4221109878 cites W3046356357 @default.
- W4221109878 cites W3112376646 @default.
- W4221109878 cites W3123997054 @default.
- W4221109878 cites W3195375135 @default.
- W4221109878 cites W3199069597 @default.
- W4221109878 doi "https://doi.org/10.1111/gtc.12917" @default.
- W4221109878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34954861" @default.
- W4221109878 hasPublicationYear "2022" @default.
- W4221109878 type Work @default.
- W4221109878 citedByCount "3" @default.
- W4221109878 countsByYear W42211098782022 @default.
- W4221109878 countsByYear W42211098782023 @default.
- W4221109878 crossrefType "journal-article" @default.
- W4221109878 hasAuthorship W4221109878A5027556590 @default.
- W4221109878 hasAuthorship W4221109878A5041944234 @default.
- W4221109878 hasAuthorship W4221109878A5076604047 @default.
- W4221109878 hasAuthorship W4221109878A5079151324 @default.
- W4221109878 hasAuthorship W4221109878A5084765225 @default.
- W4221109878 hasAuthorship W4221109878A5089509720 @default.
- W4221109878 hasAuthorship W4221109878A5090579064 @default.
- W4221109878 hasBestOaLocation W42211098782 @default.
- W4221109878 hasConcept C126725582 @default.
- W4221109878 hasConcept C133882971 @default.
- W4221109878 hasConcept C134306372 @default.
- W4221109878 hasConcept C14036430 @default.
- W4221109878 hasConcept C186435350 @default.
- W4221109878 hasConcept C190062978 @default.
- W4221109878 hasConcept C2780114586 @default.
- W4221109878 hasConcept C33923547 @default.
- W4221109878 hasConcept C36503486 @default.
- W4221109878 hasConcept C49805395 @default.
- W4221109878 hasConcept C59157529 @default.