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- W4221114241 abstract "Myeloproliferative neoplasm (MPN) in humans and domestic animals can usually be diagnosed with reasonable certainty based on history, clinical signs, and serial CBCs. Diagnosis of MPN in human patients and experimental settings are aided by a wider array of tools to prove a clonal etiology, including fluorescence in situ hybridization cytogenetics, X-linked clonality assay, and specific genetic assays for driver mutations. The veterinary classification of MPN has not been independently updated since adoption of the 2016 WHO criteria and remains rudimentary and based on sporadic case reports rather than large studies. MPNs include several variants that overproduce leukocytes, including chronic neutrophilic leukemia, chronic myeloid leukemia, and chronic eosinophilic leukemia. Polycythemia vera is an uncommon MPN in dogs, cats, and calves characterized by overproduction of mature erythrocytes. Myelofibrosis is the proliferation of stromal fibroblasts that produce reticulin and collagen fibrils." @default.
- W4221114241 created "2022-04-03" @default.
- W4221114241 creator A5053422310 @default.
- W4221114241 date "2022-03-04" @default.
- W4221114241 modified "2023-09-27" @default.
- W4221114241 title "Myeloproliferative Neoplasms" @default.
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- W4221114241 doi "https://doi.org/10.1002/9781119500537.ch66" @default.
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