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• W4221117642 abstract "Abstract Background The GMP-compliant production of radiopharmaceuticals has been performed using disposable units (cassettes) with a dedicated synthesis module. To expand this “plug ‘n’ synthesize” principle to a broader scope of modules we developed a pressure controlled setup that offers an alternative to the usual stepper motor controlled rotary valves. The new concept was successfully applied to the synthesis of N -methyl-[ 11 C]choline, L - S -methyl-[ 11 C]methionine and [ 11 C]acetate. Results The target gas purification of cyclotron produced [ 11 C]CO 2 and subsequent conversion to [ 11 C]MeI was carried out on a TRACERlab Fx C Pro module. The labelling reactions were controlled with a TRACERlab Fx FE module. With the presented modular principle we were able to produce N -methyl-[ 11 C]choline and L - S -methyl-[ 11 C]methionine by loading a reaction loop with neat N,N' -dimethylaminoethanol (DMAE) or an ethanol/water mixture of NaOH and L -homocysteine ( L -HC), respectively and a subsequent reaction with [ 11 C]MeI. After 18 min N -methyl-[ 11 C]choline was isolated with 52% decay corrected yield and a radiochemical purity of > 99%. For L - S -methyl-[ 11 C]methionine the total reaction time was 19 min reaction, yielding 25% of pure product (> 97%). The reactor design was used as an exemplary model for the technically challenging [ 11 C]acetate synthesis. The disposable unit was filled with 1 mL MeMgCl (0.75 M) in tetrahydrofuran (THF) bevore [ 11 C]CO 2 was passed through. After complete release of [ 11 C]CO 2 the reaction mixture was quenched with water and guided through a series of ion exchangers (H + , Ag + and OH − ). The product was retained on a strong anion exchanger, washed with water and finally extracted with saline. The product mixture was acidified and degassed to separate excess [ 11 C]CO 2 before dispensing. Under these conditions the total reaction time was 18 ± 2 min and pure [ 11 C]acetate (n = 10) was isolated with a decay corrected yield of 51 ± 5%. Conclusion Herein, we described a novel single use unit for the synthesis of carbon-11 labelled tracers for preclinical and clinical applications of N -methyl-[ 11 C]choline, L - S -methyl-[ 11 C]methionine and [ 11 C]acetate." @default.
• W4221117642 created "2022-04-03" @default.
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• W4221117642 date "2022-03-28" @default.
• W4221117642 modified "2023-09-26" @default.
• W4221117642 title "A new concept for the production of 11C-labelled radiotracers" @default.
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• W4221117642 doi "https://doi.org/10.1186/s41181-022-00159-y" @default.
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