FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221120349> ?p ?o ?g. }

• W4221120349 abstract "Prenatal exposure to maternal immune activation (MIA) has been suggested to increase the probability of autism spectrum disorder (ASD). Recent evidence from animal studies indicates a key role for interleukin-17a (IL-17a) in promoting MIA-induced behavioral and brain abnormalities reminiscent of ASD. However, it is still unclear how IL-17a acts on the human developing brain and the cell types directly affected by IL-17a signaling. In this study, we used iPSC-derived neural progenitor cells (NPCs) from individuals with ASD of known and unknown genetic cause as well as from neurotypical controls to examine the effects of exogenous IL-17a on NPC proliferation, migration and neuronal differentiation, and whether IL-17a and genetic risk factors for ASD interact exacerbating alterations in NPC function. We observed that ASD and control NPCs endogenously express IL-17a receptor (IL17RA), and that IL-17a/IL17RA activation modulates downstream ERK1/2 and mTORC1 signaling pathways. Exogenous IL-17a did not induce abnormal proliferation and migration of ASD and control NPCs but, on the other hand, it significantly increased the expression of synaptic (Synaptophysin-1, Synapsin-1) and neuronal polarity (MAP2) proteins in these cells. Also, as we observed that ASD and control NPCs exhibited similar responses to exogenous IL-17a, it is possible that a more inflammatory environment containing other immune molecules besides IL-17a may be needed to trigger gene-environment interactions during neurodevelopment. In conclusion, our results suggest that exogenous IL-17a positively regulates the neuronal differentiation of human NPCs, which may disturb normal neuronal and synaptic development and contribute to MIA-related changes in brain function and behavior." @default.
• W4221120349 created "2022-04-03" @default.
• W4221120349 creator A5017415951 @default.
• W4221120349 creator A5033739891 @default.
• W4221120349 creator A5040776671 @default.
• W4221120349 creator A5058520074 @default.
• W4221120349 creator A5081822058 @default.
• W4221120349 creator A5090180701 @default.
• W4221120349 creator A5091327969 @default.
• W4221120349 date "2022-03-14" @default.
• W4221120349 modified "2023-10-16" @default.
• W4221120349 title "Interleukin-17a Induces Neuronal Differentiation of Induced-Pluripotent Stem Cell-Derived Neural Progenitors From Autistic and Control Subjects" @default.
• W4221120349 cites W1196239049 @default.
• W4221120349 cites W1768523798 @default.
• W4221120349 cites W1774639140 @default.
• W4221120349 cites W1907855477 @default.
• W4221120349 cites W1921268863 @default.
• W4221120349 cites W1972651024 @default.
• W4221120349 cites W1981079086 @default.
• W4221120349 cites W1981492377 @default.
• W4221120349 cites W1993642204 @default.
• W4221120349 cites W2020233428 @default.
• W4221120349 cites W2023727946 @default.
• W4221120349 cites W2023766860 @default.
• W4221120349 cites W2037734036 @default.
• W4221120349 cites W2046260780 @default.
• W4221120349 cites W2048843644 @default.
• W4221120349 cites W2076597894 @default.
• W4221120349 cites W2079035204 @default.
• W4221120349 cites W2081161499 @default.
• W4221120349 cites W2084450750 @default.
• W4221120349 cites W2094362465 @default.
• W4221120349 cites W2099363651 @default.
• W4221120349 cites W2110691073 @default.
• W4221120349 cites W2125531274 @default.
• W4221120349 cites W2132438753 @default.
• W4221120349 cites W2154965665 @default.
• W4221120349 cites W2164938398 @default.
• W4221120349 cites W2166555967 @default.
• W4221120349 cites W2253802357 @default.
• W4221120349 cites W2402416000 @default.
• W4221120349 cites W2461476914 @default.
• W4221120349 cites W2470092373 @default.
• W4221120349 cites W2553689063 @default.
• W4221120349 cites W2590599688 @default.
• W4221120349 cites W2619660012 @default.
• W4221120349 cites W2754172044 @default.
• W4221120349 cites W2754986416 @default.
• W4221120349 cites W2778743820 @default.
• W4221120349 cites W2810248457 @default.
• W4221120349 cites W2811412005 @default.
• W4221120349 cites W2945896643 @default.
• W4221120349 cites W2952743173 @default.
• W4221120349 cites W2955128890 @default.
• W4221120349 cites W2983921917 @default.
• W4221120349 cites W2994770641 @default.
• W4221120349 cites W3006031924 @default.
• W4221120349 cites W3007292641 @default.
• W4221120349 cites W3033140177 @default.
• W4221120349 cites W3035399741 @default.
• W4221120349 cites W3085338548 @default.
• W4221120349 cites W3159389724 @default.
• W4221120349 doi "https://doi.org/10.3389/fnins.2022.828646" @default.
• W4221120349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35360153" @default.
• W4221120349 hasPublicationYear "2022" @default.
• W4221120349 type Work @default.
• W4221120349 citedByCount "3" @default.
• W4221120349 countsByYear W42211203492022 @default.
• W4221120349 countsByYear W42211203492023 @default.
• W4221120349 crossrefType "journal-article" @default.
• W4221120349 hasAuthorship W4221120349A5017415951 @default.
• W4221120349 hasAuthorship W4221120349A5033739891 @default.
• W4221120349 hasAuthorship W4221120349A5040776671 @default.
• W4221120349 hasAuthorship W4221120349A5058520074 @default.
• W4221120349 hasAuthorship W4221120349A5081822058 @default.
• W4221120349 hasAuthorship W4221120349A5090180701 @default.
• W4221120349 hasAuthorship W4221120349A5091327969 @default.
• W4221120349 hasBestOaLocation W42211203491 @default.
• W4221120349 hasConcept C104317684 @default.
• W4221120349 hasConcept C136834591 @default.
• W4221120349 hasConcept C148738053 @default.
• W4221120349 hasConcept C169760540 @default.
• W4221120349 hasConcept C201750760 @default.
• W4221120349 hasConcept C28328180 @default.
• W4221120349 hasConcept C4746552 @default.
• W4221120349 hasConcept C54355233 @default.
• W4221120349 hasConcept C86803240 @default.
• W4221120349 hasConcept C95444343 @default.
• W4221120349 hasConceptScore W4221120349C104317684 @default.
• W4221120349 hasConceptScore W4221120349C136834591 @default.
• W4221120349 hasConceptScore W4221120349C148738053 @default.
• W4221120349 hasConceptScore W4221120349C169760540 @default.
• W4221120349 hasConceptScore W4221120349C201750760 @default.
• W4221120349 hasConceptScore W4221120349C28328180 @default.
• W4221120349 hasConceptScore W4221120349C4746552 @default.
• W4221120349 hasConceptScore W4221120349C54355233 @default.
• W4221120349 hasConceptScore W4221120349C86803240 @default.
• W4221120349 hasConceptScore W4221120349C95444343 @default.
• W4221120349 hasFunder F4320320997 @default.
• W4221120349 hasFunder F4320322025 @default.

• next