FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221120689> ?p ?o ?g. }

• W4221120689 abstract "The immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the alternative pathway. However, the specific complement proteins involved in the development of the type 2 diabetes mellitus (T2DM) and cognitive impairment are still unclear. Here, we investigated complement proteins in serum from patients with T2DM, cognitive impairment, or both T2DM and cognitive impairment.To investigate the levels of serum immune complement proteins in patients with T2DM, cognitive impairment, or T2DM combined with cognitive impairment and the associations between these complement proteins and risk factors for T2DM or cognitive impairment.Clinical markers were collected from blood samples of 264 participants. Luminex multiplex assays were used to detect serum complement proteins. All statistical analyses were performed using Prism or R studio.There was a difference in serum levels of the complement proteins C1q, C3, C3b, and FH between the three different groups. Hyperglycemia was significantly correlated with elevated C3b or reduced C3, C1q, and FH. In addition, hyperlipidemia was positively correlated with elevated levels of C3, C4, C1q, and FH proteins. There was an association between C1q, C3, C4, and FH and β-pancreas cell function, whereas only FH was associated with insulin resistance. Higher serum C1q was significantly associated with an increased risk of cognitive impairment.Serum levels of complement proteins were closely associated with hyperglycemia and hyperlipidemia. We found that classical complement pathway activation mainly occurred in the cognitive impairment only group, whereas the alternative pathway may reflect T2DM and T2DM with cognitive impairment." @default.
• W4221120689 created "2022-04-03" @default.
• W4221120689 creator A5000125292 @default.
• W4221120689 creator A5012576218 @default.
• W4221120689 creator A5034461869 @default.
• W4221120689 creator A5070834732 @default.
• W4221120689 creator A5080308075 @default.
• W4221120689 creator A5084532963 @default.
• W4221120689 date "2022-03-08" @default.
• W4221120689 modified "2023-09-30" @default.
• W4221120689 title "Different Complement Activation Pathways Underly Cognitive Impairment and Type 2 Diabetes Mellitus Combined With Cognitive Impairment" @default.
• W4221120689 cites W1827453524 @default.
• W4221120689 cites W1988761237 @default.
• W4221120689 cites W2019724009 @default.
• W4221120689 cites W2057213039 @default.
• W4221120689 cites W2070576387 @default.
• W4221120689 cites W2082409119 @default.
• W4221120689 cites W2083466958 @default.
• W4221120689 cites W2096327192 @default.
• W4221120689 cites W2102528806 @default.
• W4221120689 cites W2103102216 @default.
• W4221120689 cites W2124386285 @default.
• W4221120689 cites W2163243965 @default.
• W4221120689 cites W2164179897 @default.
• W4221120689 cites W2168489336 @default.
• W4221120689 cites W2169342672 @default.
• W4221120689 cites W2169637270 @default.
• W4221120689 cites W2255138985 @default.
• W4221120689 cites W2263406196 @default.
• W4221120689 cites W2289584262 @default.
• W4221120689 cites W2298789261 @default.
• W4221120689 cites W2314634699 @default.
• W4221120689 cites W2323758773 @default.
• W4221120689 cites W2594651069 @default.
• W4221120689 cites W2623583708 @default.
• W4221120689 cites W2757079655 @default.
• W4221120689 cites W2767013543 @default.
• W4221120689 cites W2769984699 @default.
• W4221120689 cites W2786962139 @default.
• W4221120689 cites W2790302921 @default.
• W4221120689 cites W2794648992 @default.
• W4221120689 cites W2806211187 @default.
• W4221120689 cites W2884127226 @default.
• W4221120689 cites W2884234047 @default.
• W4221120689 cites W2892196137 @default.
• W4221120689 cites W2938743978 @default.
• W4221120689 cites W2942790287 @default.
• W4221120689 cites W2947126461 @default.
• W4221120689 cites W2965300600 @default.
• W4221120689 cites W2986782615 @default.
• W4221120689 cites W2994901254 @default.
• W4221120689 cites W3013820019 @default.
• W4221120689 cites W3091026034 @default.
• W4221120689 cites W3108589403 @default.
• W4221120689 cites W3109073748 @default.
• W4221120689 cites W3173650196 @default.
• W4221120689 cites W4211058450 @default.
• W4221120689 cites W44929223 @default.
• W4221120689 doi "https://doi.org/10.3389/fnagi.2022.810335" @default.
• W4221120689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35370615" @default.
• W4221120689 hasPublicationYear "2022" @default.
• W4221120689 type Work @default.
• W4221120689 citedByCount "2" @default.
• W4221120689 countsByYear W42211206892023 @default.
• W4221120689 crossrefType "journal-article" @default.
• W4221120689 hasAuthorship W4221120689A5000125292 @default.
• W4221120689 hasAuthorship W4221120689A5012576218 @default.
• W4221120689 hasAuthorship W4221120689A5034461869 @default.
• W4221120689 hasAuthorship W4221120689A5070834732 @default.
• W4221120689 hasAuthorship W4221120689A5080308075 @default.
• W4221120689 hasAuthorship W4221120689A5084532963 @default.
• W4221120689 hasBestOaLocation W42211206891 @default.
• W4221120689 hasConcept C104317684 @default.
• W4221120689 hasConcept C111684460 @default.
• W4221120689 hasConcept C112313634 @default.
• W4221120689 hasConcept C126322002 @default.
• W4221120689 hasConcept C127716648 @default.
• W4221120689 hasConcept C134018914 @default.
• W4221120689 hasConcept C14356644 @default.
• W4221120689 hasConcept C15744967 @default.
• W4221120689 hasConcept C169760540 @default.
• W4221120689 hasConcept C169900460 @default.
• W4221120689 hasConcept C188082640 @default.
• W4221120689 hasConcept C189446657 @default.
• W4221120689 hasConcept C203014093 @default.
• W4221120689 hasConcept C203473731 @default.
• W4221120689 hasConcept C2779091943 @default.
• W4221120689 hasConcept C2779134260 @default.
• W4221120689 hasConcept C2910068830 @default.
• W4221120689 hasConcept C2984915365 @default.
• W4221120689 hasConcept C55493867 @default.
• W4221120689 hasConcept C555293320 @default.
• W4221120689 hasConcept C71924100 @default.
• W4221120689 hasConcept C86803240 @default.
• W4221120689 hasConcept C8891405 @default.
• W4221120689 hasConcept C90630246 @default.
• W4221120689 hasConceptScore W4221120689C104317684 @default.
• W4221120689 hasConceptScore W4221120689C111684460 @default.
• W4221120689 hasConceptScore W4221120689C112313634 @default.
• W4221120689 hasConceptScore W4221120689C126322002 @default.

• next