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- W4221123886 abstract "Abstract Inflammatory bowel diseases (IBD) are chronic and relapsing inflammatory disorders of the gastrointestinal tract with complex etiology and no strategies for complete cure. IBD are often complicated by mental disorders like anxiety and depression, indicating substantial shifts in the gut-brain axis. However, the mechanisms connecting IBD to mental diseases are still under debate. Here we use Muc2 mutant mouse model of chronic colitis to uncouple the effects of the intestinal microbiota on host behavior from chronic inflammation in the gut. Muc2 mutant male mice exhibit high exploratory activity, reduced anxiety-related behaviors, impaired sensorimotor gating, and altered social preference towards males and females. Microbial transfer to wild-type mice via littermate co-housing shows that colitis-associated microbiota rather than inflammation per se defines behavioral features in Muc2 colitis model. Metagenomic profiling and combination of antibiotic treatments revealed that bacterial species Akkermansia muciniphila is associated with the behavioral phenotype in mutants, and that its intestinal abundance correlates with social preference towards males. Metabolomic analysis together with pharmacological inhibition of Gly and NMDA receptors helped us to determine that brain glycine is responsible for the behavioral phenotype in Muc2 mice. Blood and brain metabolic profiles suggest that microbiota-dependent changes in choline metabolism might be involved in regulation of central glycine neurotransmission. Taken together, our data demonstrates that colitis-associated microbiota controls anxiety, sensorimotor gating and social behavior via metabolic regulation of the brain glycinergic system, providing new venues to combat neurological complications of IBD." @default.
- W4221123886 created "2022-04-03" @default.
- W4221123886 creator A5004268894 @default.
- W4221123886 creator A5005699239 @default.
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- W4221123886 creator A5022644174 @default.
- W4221123886 creator A5053253942 @default.
- W4221123886 creator A5089769883 @default.
- W4221123886 date "2022-03-07" @default.
- W4221123886 modified "2023-10-18" @default.
- W4221123886 title "Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice" @default.
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