FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221124918> ?p ?o ?g. }

• W4221124918 endingPage "936" @default.
• W4221124918 startingPage "926" @default.
• W4221124918 abstract "Phytochemical investigation of the methanol extract of the seeds of P. harmala afforded two new alkaloids namely, 1‑hydroxy-1-norharmaline (4) and 7-norharmalacidine hydrochloride (5) and a new semisynthetic derivative, 1,2-diacetyl-1-nor-harmaline hydrochloride (2Ac/4Ac). Additionally, four known derivatives viz., harmine (1), harmalacidine hydrochloride (2), harmaline hydrochloride (3), and harmaline (3AB) were identified. The structures of these compounds were elucidated using NMR, HR-ESIMS, and FTIR spectroscopy. Compounds 3 and 2Ac/4Ac showed the maximum in vitro COX-2 inhibition (IC50 2.638 and 9.294 μM, respectively), whereas remarkable 5-LOX inhibition was recorded for 3, 3AB, 4, and 2Ac/4Ac (IC50 1.63, 4.596, 6.174, and 3.237 μM, respectively). Docking studies showed the ability of 2 and 2Ac/4Ac to establish H-bonds with the crucial residues, Tyr385, Tyr355, and Arg120 of COX-2 enzymes. Also, compounds 2, 4, 5, and 2Ac/4Ac showed the ability to coordinate with the iron metal in 5-LOX. Our results suggested β-carboline alkaloids as promising leads for developing new anti-inflammatory drugs." @default.
• W4221124918 created "2022-04-03" @default.
• W4221124918 creator A5041544655 @default.
• W4221124918 creator A5056910751 @default.
• W4221124918 creator A5057326483 @default.
• W4221124918 creator A5060008169 @default.
• W4221124918 creator A5071220673 @default.
• W4221124918 date "2022-07-01" @default.
• W4221124918 modified "2023-10-16" @default.
• W4221124918 title "In vitro and in silico inhibition of COX-2 and 5-LOX by beta-carboline alkaloids from the seeds of Peganum harmala L." @default.
• W4221124918 cites W123696023 @default.
• W4221124918 cites W1488731119 @default.
• W4221124918 cites W1529692801 @default.
• W4221124918 cites W1980990431 @default.
• W4221124918 cites W1989513049 @default.
• W4221124918 cites W1994616470 @default.
• W4221124918 cites W2003225189 @default.
• W4221124918 cites W2003545828 @default.
• W4221124918 cites W2015101897 @default.
• W4221124918 cites W2020442377 @default.
• W4221124918 cites W2029867817 @default.
• W4221124918 cites W2030850720 @default.
• W4221124918 cites W2031966141 @default.
• W4221124918 cites W2055483434 @default.
• W4221124918 cites W2091868395 @default.
• W4221124918 cites W2108777528 @default.
• W4221124918 cites W2133088635 @default.
• W4221124918 cites W2209061535 @default.
• W4221124918 cites W2419540212 @default.
• W4221124918 cites W2597476897 @default.
• W4221124918 cites W2618895617 @default.
• W4221124918 cites W2770210248 @default.
• W4221124918 cites W2792385395 @default.
• W4221124918 cites W3005875905 @default.
• W4221124918 cites W3037268324 @default.
• W4221124918 cites W3039707154 @default.
• W4221124918 cites W3089890743 @default.
• W4221124918 cites W3131439703 @default.
• W4221124918 cites W3156858381 @default.
• W4221124918 cites W3177140652 @default.
• W4221124918 cites W3202194987 @default.
• W4221124918 cites W4241233965 @default.
• W4221124918 doi "https://doi.org/10.1016/j.sajb.2022.03.044" @default.
• W4221124918 hasPublicationYear "2022" @default.
• W4221124918 type Work @default.
• W4221124918 citedByCount "3" @default.
• W4221124918 countsByYear W42211249182023 @default.
• W4221124918 crossrefType "journal-article" @default.
• W4221124918 hasAuthorship W4221124918A5041544655 @default.
• W4221124918 hasAuthorship W4221124918A5056910751 @default.
• W4221124918 hasAuthorship W4221124918A5057326483 @default.
• W4221124918 hasAuthorship W4221124918A5060008169 @default.
• W4221124918 hasAuthorship W4221124918A5071220673 @default.
• W4221124918 hasConcept C104317684 @default.
• W4221124918 hasConcept C185592680 @default.
• W4221124918 hasConcept C195475562 @default.
• W4221124918 hasConcept C202751555 @default.
• W4221124918 hasConcept C2775905019 @default.
• W4221124918 hasConcept C2776460385 @default.
• W4221124918 hasConcept C2777752497 @default.
• W4221124918 hasConcept C2780237542 @default.
• W4221124918 hasConcept C2780560928 @default.
• W4221124918 hasConcept C2781450507 @default.
• W4221124918 hasConcept C55493867 @default.
• W4221124918 hasConcept C556039675 @default.
• W4221124918 hasConcept C71240020 @default.
• W4221124918 hasConcept C71924100 @default.
• W4221124918 hasConcept C86803240 @default.
• W4221124918 hasConcept C98274493 @default.
• W4221124918 hasConceptScore W4221124918C104317684 @default.
• W4221124918 hasConceptScore W4221124918C185592680 @default.
• W4221124918 hasConceptScore W4221124918C195475562 @default.
• W4221124918 hasConceptScore W4221124918C202751555 @default.
• W4221124918 hasConceptScore W4221124918C2775905019 @default.
• W4221124918 hasConceptScore W4221124918C2776460385 @default.
• W4221124918 hasConceptScore W4221124918C2777752497 @default.
• W4221124918 hasConceptScore W4221124918C2780237542 @default.
• W4221124918 hasConceptScore W4221124918C2780560928 @default.
• W4221124918 hasConceptScore W4221124918C2781450507 @default.
• W4221124918 hasConceptScore W4221124918C55493867 @default.
• W4221124918 hasConceptScore W4221124918C556039675 @default.
• W4221124918 hasConceptScore W4221124918C71240020 @default.
• W4221124918 hasConceptScore W4221124918C71924100 @default.
• W4221124918 hasConceptScore W4221124918C86803240 @default.
• W4221124918 hasConceptScore W4221124918C98274493 @default.
• W4221124918 hasLocation W42211249181 @default.
• W4221124918 hasOpenAccess W4221124918 @default.
• W4221124918 hasPrimaryLocation W42211249181 @default.
• W4221124918 hasRelatedWork W1604655086 @default.
• W4221124918 hasRelatedWork W2029867817 @default.
• W4221124918 hasRelatedWork W2169624105 @default.
• W4221124918 hasRelatedWork W2201764257 @default.
• W4221124918 hasRelatedWork W2349158726 @default.
• W4221124918 hasRelatedWork W2383492109 @default.
• W4221124918 hasRelatedWork W2388406013 @default.
• W4221124918 hasRelatedWork W2389570099 @default.
• W4221124918 hasRelatedWork W2522125513 @default.
• W4221124918 hasRelatedWork W3207415196 @default.

• next