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- W4221127508 abstract "The great majority of SARS-CoV-2 infections are mild and uncomplicated, but some individuals with initially mild COVID-19 progressively develop more severe symptoms. Furthermore, there is substantial heterogeneity in SARS-CoV-2-specific memory immune responses following infection. There remains a critical need to identify host immune biomarkers predictive of clinical and immunologic outcomes in SARS-CoV-2-infected patients. Leveraging longitudinal samples and data from a clinical trial in SARS-CoV-2 infected outpatients, we used host proteomics and transcriptomics to characterize the trajectory of the immune response in COVID-19 patients within the first 2 weeks of symptom onset. We identify early immune signatures, including plasma RIG-I levels, early interferon signaling, and related cytokines (CXCL10, MCP1, MCP-2 and MCP-3) associated with subsequent disease progression, control of viral shedding, and the SARS-CoV-2 specific T cell and antibody response measured up to 7 months after enrollment. We found that several biomarkers for immunological outcomes are shared between individuals receiving BNT162b2 (Pfizerâ€BioNTech) vaccine and COVID-19 patients. Finally, we demonstrate that machine learning models using 7-10 plasma protein markers measured early within the course of infection are able to accurately predict disease progression, T cell memory, and the antibody response post-infection in a second, independent dataset." @default.
- W4221127508 created "2022-04-03" @default.
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- W4221127508 date "2022-02-02" @default.
- W4221127508 modified "2023-10-06" @default.
- W4221127508 title "Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19" @default.
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- W4221127508 doi "https://doi.org/10.21203/rs.3.rs-847082/v1" @default.
- W4221127508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35132407" @default.
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