FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221128901> ?p ?o ?g. }

• W4221128901 abstract "Acute Respiratory Distress Syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, has no cure. Hypoxemia is a defining feature, yet its impact on inflammation is often neglected. Patients with ARDS are monocytopenic early in the onset of the disease. Endotoxin or Streptococcus pneumoniae acute lung injury (ALI) in the context of hypoxia replicates this finding, through hypoxia-driven suppression of type I interferon signalling. This results in failed lung monocyte-derived interstitial macrophages (IM) niche expansion and unchecked neutrophilic inflammation. Administration of colony stimulating factor 1 (CSF1) rescues the monocytopenia, alters the circulating classical monocyte phenotype in hypoxic endotoxin-driven ALI and enables lung IM population expansion, thus limiting lung injury in endotoxin- and virally-induced hypoxic ALI. Hypoxia directly alters immune dynamics to the detriment of the host and manipulation of this aberrant response offers new therapeutic strategies for ARDS." @default.
• W4221128901 created "2022-04-03" @default.
• W4221128901 creator A5003549501 @default.
• W4221128901 creator A5003974129 @default.
• W4221128901 creator A5004882728 @default.
• W4221128901 creator A5005356735 @default.
• W4221128901 creator A5006746030 @default.
• W4221128901 creator A5007593421 @default.
• W4221128901 creator A5010843495 @default.
• W4221128901 creator A5011043646 @default.
• W4221128901 creator A5011799742 @default.
• W4221128901 creator A5012684804 @default.
• W4221128901 creator A5013106882 @default.
• W4221128901 creator A5014938248 @default.
• W4221128901 creator A5017461128 @default.
• W4221128901 creator A5018437752 @default.
• W4221128901 creator A5025492210 @default.
• W4221128901 creator A5029715770 @default.
• W4221128901 creator A5030245394 @default.
• W4221128901 creator A5030523023 @default.
• W4221128901 creator A5039347793 @default.
• W4221128901 creator A5040837932 @default.
• W4221128901 creator A5042861631 @default.
• W4221128901 creator A5047091057 @default.
• W4221128901 creator A5047229923 @default.
• W4221128901 creator A5050917455 @default.
• W4221128901 creator A5051351228 @default.
• W4221128901 creator A5051710302 @default.
• W4221128901 creator A5054119616 @default.
• W4221128901 creator A5054628399 @default.
• W4221128901 creator A5056600871 @default.
• W4221128901 creator A5058085497 @default.
• W4221128901 creator A5063357947 @default.
• W4221128901 creator A5063514375 @default.
• W4221128901 creator A5064725555 @default.
• W4221128901 creator A5064727417 @default.
• W4221128901 creator A5064919088 @default.
• W4221128901 creator A5067352055 @default.
• W4221128901 creator A5071402231 @default.
• W4221128901 creator A5076844781 @default.
• W4221128901 creator A5081809096 @default.
• W4221128901 creator A5088297667 @default.
• W4221128901 creator A5088655120 @default.
• W4221128901 date "2022-03-12" @default.
• W4221128901 modified "2023-09-22" @default.
• W4221128901 title "Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence" @default.
• W4221128901 doi "https://doi.org/10.1101/2022.03.11.483935" @default.
• W4221128901 hasPublicationYear "2022" @default.
• W4221128901 type Work @default.
• W4221128901 citedByCount "0" @default.
• W4221128901 crossrefType "posted-content" @default.
• W4221128901 hasAuthorship W4221128901A5003549501 @default.
• W4221128901 hasAuthorship W4221128901A5003974129 @default.
• W4221128901 hasAuthorship W4221128901A5004882728 @default.
• W4221128901 hasAuthorship W4221128901A5005356735 @default.
• W4221128901 hasAuthorship W4221128901A5006746030 @default.
• W4221128901 hasAuthorship W4221128901A5007593421 @default.
• W4221128901 hasAuthorship W4221128901A5010843495 @default.
• W4221128901 hasAuthorship W4221128901A5011043646 @default.
• W4221128901 hasAuthorship W4221128901A5011799742 @default.
• W4221128901 hasAuthorship W4221128901A5012684804 @default.
• W4221128901 hasAuthorship W4221128901A5013106882 @default.
• W4221128901 hasAuthorship W4221128901A5014938248 @default.
• W4221128901 hasAuthorship W4221128901A5017461128 @default.
• W4221128901 hasAuthorship W4221128901A5018437752 @default.
• W4221128901 hasAuthorship W4221128901A5025492210 @default.
• W4221128901 hasAuthorship W4221128901A5029715770 @default.
• W4221128901 hasAuthorship W4221128901A5030245394 @default.
• W4221128901 hasAuthorship W4221128901A5030523023 @default.
• W4221128901 hasAuthorship W4221128901A5039347793 @default.
• W4221128901 hasAuthorship W4221128901A5040837932 @default.
• W4221128901 hasAuthorship W4221128901A5042861631 @default.
• W4221128901 hasAuthorship W4221128901A5047091057 @default.
• W4221128901 hasAuthorship W4221128901A5047229923 @default.
• W4221128901 hasAuthorship W4221128901A5050917455 @default.
• W4221128901 hasAuthorship W4221128901A5051351228 @default.
• W4221128901 hasAuthorship W4221128901A5051710302 @default.
• W4221128901 hasAuthorship W4221128901A5054119616 @default.
• W4221128901 hasAuthorship W4221128901A5054628399 @default.
• W4221128901 hasAuthorship W4221128901A5056600871 @default.
• W4221128901 hasAuthorship W4221128901A5058085497 @default.
• W4221128901 hasAuthorship W4221128901A5063357947 @default.
• W4221128901 hasAuthorship W4221128901A5063514375 @default.
• W4221128901 hasAuthorship W4221128901A5064725555 @default.
• W4221128901 hasAuthorship W4221128901A5064727417 @default.
• W4221128901 hasAuthorship W4221128901A5064919088 @default.
• W4221128901 hasAuthorship W4221128901A5067352055 @default.
• W4221128901 hasAuthorship W4221128901A5071402231 @default.
• W4221128901 hasAuthorship W4221128901A5076844781 @default.
• W4221128901 hasAuthorship W4221128901A5081809096 @default.
• W4221128901 hasAuthorship W4221128901A5088297667 @default.
• W4221128901 hasAuthorship W4221128901A5088655120 @default.
• W4221128901 hasBestOaLocation W42211289011 @default.
• W4221128901 hasConcept C126322002 @default.
• W4221128901 hasConcept C164027704 @default.
• W4221128901 hasConcept C178790620 @default.
• W4221128901 hasConcept C185592680 @default.
• W4221128901 hasConcept C203014093 @default.
• W4221128901 hasConcept C2776348555 @default.
• W4221128901 hasConcept C2776779939 @default.

• next