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• W4221129172 endingPage "1477" @default.
• W4221129172 startingPage "1460" @default.
• W4221129172 abstract "Recent spinal cord literature abounds with descriptions of genetic preprogramming and the molecular control of circuit formation. In this paper, we explore to what extent circuit formation based on learning rather than preprogramming could explain the selective formation of the monosynaptic projections between muscle spindle primary afferents and homonymous motoneurons. We adjusted the initially randomized gains in the neural network according to a Hebbian plasticity rule while exercising the model system with spontaneous muscle activity patterns similar to those observed during early fetal development. Normal connectivity patterns developed only when we modeled β motoneurons, which are known to innervate both intrafusal and extrafusal muscle fibers in vertebrate muscles but were not considered in previous literature regarding selective formation of these synapses in animals with paralyzed muscles. It was also helpful to correctly model the greatly reduced contractility of extrafusal muscle fibers during early development. Stronger and more coordinated muscle activity patterns such as observed later during neonatal locomotion impaired projection selectivity. These findings imply a generic functionality of a musculoskeletal system to imprint important aspects of its mechanical dynamics onto a neural network, without specific preprogramming other than setting a critical period for the formation and maturation of this general pattern of connectivity. Such functionality would facilitate the successful evolution of new species with altered musculoskeletal anatomy, and it may help to explain patterns of connectivity and associated reflexes that appear during abnormal development.NEW & NOTEWORTHY A novel model of self-organization of early spinal circuitry based on a biologically realistic plant, sensors, and neuronal plasticity in conjunction with empirical observations of fetal development. Without explicit need for guiding genetic rules, connection matrices emerge that support functional self-organization of the mature pattern of Ia to motoneuron connectivity in the spinal circuitry." @default.
• W4221129172 created "2022-04-03" @default.
• W4221129172 creator A5001405796 @default.
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• W4221129172 creator A5071017373 @default.
• W4221129172 creator A5085984790 @default.
• W4221129172 date "2022-06-01" @default.
• W4221129172 modified "2023-09-27" @default.
• W4221129172 title "A model for self-organization of sensorimotor function: the spinal monosynaptic loop" @default.
• W4221129172 cites W1211422536 @default.
• W4221129172 cites W141554977 @default.
• W4221129172 cites W1513817892 @default.
• W4221129172 cites W1549114171 @default.
• W4221129172 cites W1564658350 @default.
• W4221129172 cites W170956600 @default.
• W4221129172 cites W173044785 @default.
• W4221129172 cites W1835629923 @default.
• W4221129172 cites W1941192440 @default.
• W4221129172 cites W1965513113 @default.
• W4221129172 cites W1966343749 @default.
• W4221129172 cites W1968445283 @default.
• W4221129172 cites W1982508615 @default.
• W4221129172 cites W1982857029 @default.
• W4221129172 cites W1983329616 @default.
• W4221129172 cites W1985559627 @default.
• W4221129172 cites W1992008511 @default.
• W4221129172 cites W2002972805 @default.
• W4221129172 cites W2005763203 @default.
• W4221129172 cites W2005995324 @default.
• W4221129172 cites W2010271920 @default.
• W4221129172 cites W2012540599 @default.
• W4221129172 cites W2015951071 @default.
• W4221129172 cites W2023459285 @default.
• W4221129172 cites W2024875612 @default.
• W4221129172 cites W2028619567 @default.
• W4221129172 cites W2032943627 @default.
• W4221129172 cites W2050899993 @default.
• W4221129172 cites W2052812788 @default.
• W4221129172 cites W2060052789 @default.
• W4221129172 cites W2060087154 @default.
• W4221129172 cites W2069613207 @default.
• W4221129172 cites W2074566935 @default.
• W4221129172 cites W2074665954 @default.
• W4221129172 cites W2079344476 @default.
• W4221129172 cites W2079428986 @default.
• W4221129172 cites W2081102786 @default.
• W4221129172 cites W2084436917 @default.
• W4221129172 cites W2085325012 @default.
• W4221129172 cites W2087888300 @default.
• W4221129172 cites W2095511833 @default.
• W4221129172 cites W2095967764 @default.
• W4221129172 cites W2108000512 @default.
• W4221129172 cites W2111015528 @default.
• W4221129172 cites W2117046678 @default.
• W4221129172 cites W2117812703 @default.
• W4221129172 cites W2121095706 @default.
• W4221129172 cites W2124834326 @default.
• W4221129172 cites W2125001634 @default.
• W4221129172 cites W2128627869 @default.
• W4221129172 cites W2129035465 @default.
• W4221129172 cites W2136304943 @default.
• W4221129172 cites W2136563262 @default.
• W4221129172 cites W2140034535 @default.
• W4221129172 cites W2140594760 @default.
• W4221129172 cites W2144690891 @default.
• W4221129172 cites W2149353021 @default.
• W4221129172 cites W2158667272 @default.
• W4221129172 cites W2166799873 @default.
• W4221129172 cites W2181970214 @default.
• W4221129172 cites W2188019123 @default.
• W4221129172 cites W2211353675 @default.
• W4221129172 cites W2215460973 @default.
• W4221129172 cites W2219541331 @default.
• W4221129172 cites W2227677454 @default.
• W4221129172 cites W231656212 @default.
• W4221129172 cites W2325193915 @default.
• W4221129172 cites W2432567885 @default.
• W4221129172 cites W2528052116 @default.
• W4221129172 cites W2573194853 @default.
• W4221129172 cites W2768387607 @default.
• W4221129172 cites W28728067 @default.
• W4221129172 cites W2885646557 @default.
• W4221129172 cites W2896423589 @default.
• W4221129172 cites W2908435993 @default.
• W4221129172 cites W2929509476 @default.
• W4221129172 cites W2944132366 @default.
• W4221129172 cites W2951767369 @default.
• W4221129172 cites W3079556417 @default.
• W4221129172 cites W3132646964 @default.
• W4221129172 cites W3161293725 @default.
• W4221129172 cites W371563080 @default.
• W4221129172 cites W49184238 @default.
• W4221129172 doi "https://doi.org/10.1152/jn.00242.2021" @default.
• W4221129172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35264006" @default.
• W4221129172 hasPublicationYear "2022" @default.
• W4221129172 type Work @default.

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