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- W4221129199 endingPage "102353" @default.
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- W4221129199 abstract "Structural studies on mammalian vitamin transport lag behind other metabolites. Folates, also known as B9 vitamins, are essential cofactors in one-carbon transfer reactions in biology. Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes. Targeting specific folate transporters is being pursued as a route to developing new antifolates with improved pharmacology. Recent structures of the proton-coupled folate transporter, PCFT, revealed key insights into antifolate recognition and the mechanism of proton-coupled transport. Combined with previously determined structures of folate receptors and new predictions for the structure of the RFC, we are now able to develop a structure-based understanding of folate and antifolate recognition to accelerate efforts in antifolate drug development." @default.
- W4221129199 created "2022-04-03" @default.
- W4221129199 creator A5017714497 @default.
- W4221129199 date "2022-06-01" @default.
- W4221129199 modified "2023-09-27" @default.
- W4221129199 title "Structural basis for recognition and transport of folic acid in mammalian cells" @default.
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- W4221129199 doi "https://doi.org/10.1016/j.sbi.2022.102353" @default.
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