Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221130145> ?p ?o ?g. }
- W4221130145 abstract "Summary The pathology of Alzheimer’s disease (AD) is associated with the extracellular amyloid-β (Aβ) plaques that perturb the mechanical properties of brain tissue. Microglia sense and integrate biochemical cues in their local microenvironment, intimate linking with AD progress. However, neither the microglial mechanosensing pathway nor its impact on AD pathogenesis is well studied. Here, we showed that the mechanosensitive ion channel Piezo1 is increased in microglia upon stiffness stimuli of Aβ fibrils. The upregulation of Piezo1 in Aβ plaque-associated microglia was observed in AD mouse models and human patients. Microglia lacking Piezo1 disturbed microglial clustering, phagocytosis, and compaction of Aβ plaques, resulting in the exacerbation of Aβ and neurodegenerative pathologies in AD. Conversely, pharmacological activation of Piezo1 ameliorated brain Aβ burden and cognitive impairment in the 5×FAD mouse. Together, our results reveal Piezo1, as a mechanosensor of Aβ fibrils stiffness in microglia, could represent a promising therapeutic target for AD." @default.
- W4221130145 created "2022-04-03" @default.
- W4221130145 creator A5000769219 @default.
- W4221130145 creator A5003518516 @default.
- W4221130145 creator A5016548937 @default.
- W4221130145 creator A5020134029 @default.
- W4221130145 creator A5026349854 @default.
- W4221130145 creator A5031426224 @default.
- W4221130145 creator A5044537971 @default.
- W4221130145 creator A5060071922 @default.
- W4221130145 creator A5065653136 @default.
- W4221130145 creator A5069993632 @default.
- W4221130145 creator A5073212256 @default.
- W4221130145 creator A5076573585 @default.
- W4221130145 creator A5081355806 @default.
- W4221130145 creator A5088333603 @default.
- W4221130145 date "2022-03-25" @default.
- W4221130145 modified "2023-09-23" @default.
- W4221130145 title "Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer’s disease" @default.
- W4221130145 cites W1495075494 @default.
- W4221130145 cites W1623920471 @default.
- W4221130145 cites W1770378670 @default.
- W4221130145 cites W1928745964 @default.
- W4221130145 cites W195691297 @default.
- W4221130145 cites W1979069664 @default.
- W4221130145 cites W1984652813 @default.
- W4221130145 cites W1991643569 @default.
- W4221130145 cites W1996545459 @default.
- W4221130145 cites W1999720993 @default.
- W4221130145 cites W2003674452 @default.
- W4221130145 cites W2012150767 @default.
- W4221130145 cites W2035618305 @default.
- W4221130145 cites W2054275187 @default.
- W4221130145 cites W2068648961 @default.
- W4221130145 cites W2073761920 @default.
- W4221130145 cites W2087270666 @default.
- W4221130145 cites W2101380445 @default.
- W4221130145 cites W2104425579 @default.
- W4221130145 cites W2105873482 @default.
- W4221130145 cites W2111200377 @default.
- W4221130145 cites W2117463741 @default.
- W4221130145 cites W2139976280 @default.
- W4221130145 cites W2160373069 @default.
- W4221130145 cites W2162143298 @default.
- W4221130145 cites W2174387682 @default.
- W4221130145 cites W2408084759 @default.
- W4221130145 cites W2416026272 @default.
- W4221130145 cites W2593979775 @default.
- W4221130145 cites W2600130478 @default.
- W4221130145 cites W2602609341 @default.
- W4221130145 cites W2611965998 @default.
- W4221130145 cites W2621129590 @default.
- W4221130145 cites W2625911761 @default.
- W4221130145 cites W2678656658 @default.
- W4221130145 cites W2729351500 @default.
- W4221130145 cites W2730872653 @default.
- W4221130145 cites W2749209632 @default.
- W4221130145 cites W2760821868 @default.
- W4221130145 cites W2769071992 @default.
- W4221130145 cites W2774947569 @default.
- W4221130145 cites W2790974918 @default.
- W4221130145 cites W2805387340 @default.
- W4221130145 cites W2896419250 @default.
- W4221130145 cites W2900328090 @default.
- W4221130145 cites W2907665228 @default.
- W4221130145 cites W2934339908 @default.
- W4221130145 cites W2952985777 @default.
- W4221130145 cites W2968420254 @default.
- W4221130145 cites W2969551943 @default.
- W4221130145 cites W2995936192 @default.
- W4221130145 cites W3000018611 @default.
- W4221130145 cites W3006368899 @default.
- W4221130145 cites W3007202428 @default.
- W4221130145 cites W3081214415 @default.
- W4221130145 cites W3111108465 @default.
- W4221130145 cites W3118666849 @default.
- W4221130145 cites W3119057232 @default.
- W4221130145 cites W3126353694 @default.
- W4221130145 cites W3165135090 @default.
- W4221130145 cites W3166797325 @default.
- W4221130145 cites W3217012249 @default.
- W4221130145 cites W4205777871 @default.
- W4221130145 cites W4206447661 @default.
- W4221130145 cites W800350851 @default.
- W4221130145 doi "https://doi.org/10.1101/2022.03.23.485446" @default.
- W4221130145 hasPublicationYear "2022" @default.
- W4221130145 type Work @default.
- W4221130145 citedByCount "1" @default.
- W4221130145 countsByYear W42211301452022 @default.
- W4221130145 crossrefType "posted-content" @default.
- W4221130145 hasAuthorship W4221130145A5000769219 @default.
- W4221130145 hasAuthorship W4221130145A5003518516 @default.
- W4221130145 hasAuthorship W4221130145A5016548937 @default.
- W4221130145 hasAuthorship W4221130145A5020134029 @default.
- W4221130145 hasAuthorship W4221130145A5026349854 @default.
- W4221130145 hasAuthorship W4221130145A5031426224 @default.
- W4221130145 hasAuthorship W4221130145A5044537971 @default.
- W4221130145 hasAuthorship W4221130145A5060071922 @default.
- W4221130145 hasAuthorship W4221130145A5065653136 @default.
- W4221130145 hasAuthorship W4221130145A5069993632 @default.