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- W4221131514 abstract "There is growing evidence that the pathogenesis of retinal diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) have a significant chronic inflammatory component. A vital part of the inflammatory cascade is through the activation of pattern recognition receptors (PRR) such as toll-like receptors (TLR). Here, we reviewed the past and current literature to ascertain the cumulative knowledge regarding the effect of TLRs on the development and progression of retinal diseases. There is burgeoning research demonstrating the relationship between TLRs and risk of developing retinal diseases, utilising a range of relevant disease models and a few large clinical investigations. The literature confirms that TLRs are involved in the development and progression of retinal diseases such as DR, AMD, and ischaemic retinopathy. Genetic polymorphisms in TLRs appear to contribute to the risk of developing AMD and DR. However, there are some inconsistencies in the published reports which require further elucidation. The evidence regarding TLR associations in retinal dystrophies including retinitis pigmentosa is limited. Based on the current evidence relating to the role of TLRs, combining anti-VEGF therapies with TLR inhibition may provide a longer-lasting treatment in some retinal vascular diseases." @default.
- W4221131514 created "2022-04-03" @default.
- W4221131514 creator A5028959597 @default.
- W4221131514 creator A5049485650 @default.
- W4221131514 creator A5069736552 @default.
- W4221131514 date "2022-03-31" @default.
- W4221131514 modified "2023-09-26" @default.
- W4221131514 title "Toll-Like Receptor Signalling Pathways and the Pathogenesis of Retinal Diseases" @default.
- W4221131514 cites W1487528435 @default.
- W4221131514 cites W1542775986 @default.
- W4221131514 cites W1575383081 @default.
- W4221131514 cites W1679113345 @default.
- W4221131514 cites W1698208302 @default.
- W4221131514 cites W182931865 @default.
- W4221131514 cites W1858336559 @default.
- W4221131514 cites W1878324289 @default.
- W4221131514 cites W1966101941 @default.
- W4221131514 cites W1970769682 @default.
- W4221131514 cites W1973659906 @default.
- W4221131514 cites W1976546025 @default.
- W4221131514 cites W1978634585 @default.
- W4221131514 cites W1979616773 @default.
- W4221131514 cites W1980993114 @default.
- W4221131514 cites W1985813464 @default.
- W4221131514 cites W1993211211 @default.
- W4221131514 cites W1994766987 @default.
- W4221131514 cites W1995744610 @default.
- W4221131514 cites W1999235650 @default.
- W4221131514 cites W2000399151 @default.
- W4221131514 cites W2000572318 @default.
- W4221131514 cites W2002540717 @default.
- W4221131514 cites W2002605819 @default.
- W4221131514 cites W2008154144 @default.
- W4221131514 cites W2008353059 @default.
- W4221131514 cites W2008955645 @default.
- W4221131514 cites W2010456451 @default.
- W4221131514 cites W2011186165 @default.
- W4221131514 cites W2012713362 @default.
- W4221131514 cites W2013583403 @default.
- W4221131514 cites W2018389491 @default.
- W4221131514 cites W2018427418 @default.
- W4221131514 cites W2018653121 @default.
- W4221131514 cites W2021759632 @default.
- W4221131514 cites W2021814263 @default.
- W4221131514 cites W2022224777 @default.
- W4221131514 cites W2025037655 @default.
- W4221131514 cites W2031571765 @default.
- W4221131514 cites W2033023829 @default.
- W4221131514 cites W2033801464 @default.
- W4221131514 cites W2042950886 @default.
- W4221131514 cites W2045711089 @default.
- W4221131514 cites W2047694702 @default.
- W4221131514 cites W2050262218 @default.
- W4221131514 cites W2052307937 @default.
- W4221131514 cites W2052634397 @default.
- W4221131514 cites W2053761680 @default.
- W4221131514 cites W2054073735 @default.
- W4221131514 cites W2059088148 @default.
- W4221131514 cites W2061217549 @default.
- W4221131514 cites W2066883715 @default.
- W4221131514 cites W2071215219 @default.
- W4221131514 cites W2072690677 @default.
- W4221131514 cites W2079078706 @default.
- W4221131514 cites W2083808530 @default.
- W4221131514 cites W2086176978 @default.
- W4221131514 cites W2087115662 @default.
- W4221131514 cites W2087899702 @default.
- W4221131514 cites W2090887081 @default.
- W4221131514 cites W2090999228 @default.
- W4221131514 cites W2092638574 @default.
- W4221131514 cites W2094198626 @default.
- W4221131514 cites W2094753668 @default.
- W4221131514 cites W2097063436 @default.
- W4221131514 cites W2097747132 @default.
- W4221131514 cites W2105125668 @default.
- W4221131514 cites W2107578953 @default.
- W4221131514 cites W2110768898 @default.
- W4221131514 cites W2113975222 @default.
- W4221131514 cites W2114208662 @default.
- W4221131514 cites W2115757439 @default.
- W4221131514 cites W2116623457 @default.
- W4221131514 cites W2117969431 @default.
- W4221131514 cites W2123195857 @default.
- W4221131514 cites W2125382661 @default.
- W4221131514 cites W2127040944 @default.
- W4221131514 cites W2129319296 @default.
- W4221131514 cites W2130271360 @default.
- W4221131514 cites W2130501069 @default.
- W4221131514 cites W2135533398 @default.
- W4221131514 cites W2137590150 @default.
- W4221131514 cites W2138480916 @default.
- W4221131514 cites W2142544676 @default.
- W4221131514 cites W2143092625 @default.
- W4221131514 cites W2148200250 @default.
- W4221131514 cites W2155897441 @default.
- W4221131514 cites W2160226180 @default.
- W4221131514 cites W2160978572 @default.
- W4221131514 cites W2161208630 @default.
- W4221131514 cites W2162993028 @default.
- W4221131514 cites W2216439475 @default.