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- W4221131805 abstract "<div>Radiopharmaceuticals are a well-known form of ionizing radiation, emitting</div><div>gamma photons. They are used in clinical routine for cancer patients; nuclear medicine</div><div>utilizes oncotropic cationic complexes such as 99mTc-Sestamibi/Tetrofosmin</div><div>(MIBI/TF); radioiodine 123I /131I; radiolabeled somatostatin (SST) derivatives 111In-</div><div>Octreoscan/99mTc- Tektrotyd; diphosphonates 99mTc-MDP /HEDP; nanoparticles 99mTc-</div><div>Nanocoll and etc. The tracer accumulation to tumor cells is dependent on blood</div><div>perfusion, biodistribution, cellular proliferation, oxygen consumption, receptor status,</div><div>and other factors in different tumors. Besides multiple imaging methods for evaluating</div><div>malignant diseases, new hybrid SPECT/CT imaging can provide accurate diagnostic</div><div>information about the presence and staging of neoplastic diseases as well as unique</div><div>biological characteristic information, such as quantification of cellular proliferation or</div><div>SST-receptor status. The SPECT component of the hybrid SPECT/CT images provides</div><div>information about the functional activity of the primary neoplastic tumor and the</div><div>secondary metastatic lesions, whereas the CT component is needed for the anatomy of</div><div>the “hot” lesions seen in the nuclear medicine modality. This may result in a reduced</div><div>number of false-positive and false-negative results and increased sensitivity and</div><div>specificity of the nuclear medicine studies. The SPECT/CT examinations may find a</div><div>different clinical value in oncology. Combined SPECT/CT images enable discovering</div><div>primary occult tumors, visualizing local or distant metastases for accurate NM-staging,</div><div>and evaluating therapy response. SPECT/CT images can be used for radiotherapy</div><div>planning to delineate target and functional gross tumor volumes.</div>" @default.
- W4221131805 created "2022-04-03" @default.
- W4221131805 date "2022-03-09" @default.
- W4221131805 modified "2023-09-23" @default.
- W4221131805 title "Role of SPECT/CT Imaging with Gamma-emitted Radionuclides in Personalized Treatment of Cancer Patients" @default.
- W4221131805 doi "https://doi.org/10.2174/9781681088655122010008" @default.
- W4221131805 hasPublicationYear "2022" @default.
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