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- W4221135037 endingPage "120464" @default.
- W4221135037 startingPage "120464" @default.
- W4221135037 abstract "SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads to bilateral atypical pneumonia with significant impairment of respiratory function. However, the infectious capacity of SARS-CoV-2 is not limited to the respiratory system, but may also affect other vital organs such as the brain. The central nervous system is vulnerable to cell damage via direct invasion or indirect virus-related effects leading to a neuroinflammatory response, processes possibly associated with a decrease in the activity of angiotensin II converting enzyme (ACE2), the canonical cell-surface receptor for SARS-CoV-2. This enzyme regulates neuroprotective and neuroimmunomodulatory functions and can neutralize both inflammation and oxidative stress generated at the cellular level. Furthermore, there is evidence of an association between vitamin D deficiency and predisposition to the development of severe forms of COVID-19, with its possible neurological and neuropsychiatric sequelae: vitamin D has the ability to down-modulate the effects of neuroinflammatory cytokines, among other anti-inflammatory/immunomodulatory effects, thus attenuating harmful consequences of COVID-19. This review critically analyzes current evidence supporting the notion that vitamin D may act as a neuroprotective and neuroreparative agent against the neurological sequelae of COVID-19." @default.
- W4221135037 created "2022-04-03" @default.
- W4221135037 creator A5006767226 @default.
- W4221135037 creator A5026627767 @default.
- W4221135037 creator A5044396037 @default.
- W4221135037 creator A5050680648 @default.
- W4221135037 creator A5053935340 @default.
- W4221135037 date "2022-05-01" @default.
- W4221135037 modified "2023-10-10" @default.
- W4221135037 title "COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent" @default.
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