FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221136077> ?p ?o ?g. }

• W4221136077 abstract "Cerebral palsy (CP) is caused by a static lesion to the brain occurring in utero or up to the first 2 years of life; it often manifests as musculoskeletal impairments and movement disorders including spasticity and contractures. Variable manifestation of the pathology across individuals, coupled with differing mechanics and treatments, leads to a heterogeneous collection of clinical phenotypes that affect muscles and individuals differently. Growth of muscles in CP deviates from typical development, evident as early as 15 months of age. Muscles in CP may be reduced in volume by as much as 40%, may be shorter in length, present longer tendons, and may have fewer sarcomeres in series that are overstretched compared to typical. Macroscale and functional deficits are likely mediated by dysfunction at the cellular level, which manifests as impaired growth. Within muscle fibres, satellite cells are decreased by as much as 40-70% and the regenerative capacity of remaining satellite cells appears compromised. Impaired muscle regeneration in CP is coupled with extracellular matrix expansion and increased pro-inflammatory gene expression; resultant muscles are smaller, stiffer, and weaker than typical muscle. These differences may contribute to individuals with CP participating in less physical activity, thus decreasing opportunities for mechanical loading, commencing a vicious cycle of muscle disuse and secondary sarcopenia. This narrative review describes the effects of CP on skeletal muscles encompassing substantive changes from whole muscle function to cell-level effects and the effects of common treatments. We discuss growth and mechanics of skeletal muscles in CP and propose areas where future work is needed to understand these interactions, particularly the link between neural insult and cell-level manifestation of CP." @default.
• W4221136077 created "2022-04-03" @default.
• W4221136077 creator A5006441780 @default.
• W4221136077 creator A5034529436 @default.
• W4221136077 creator A5039630835 @default.
• W4221136077 creator A5066096305 @default.
• W4221136077 creator A5079451770 @default.
• W4221136077 date "2022-03-10" @default.
• W4221136077 modified "2023-10-18" @default.
• W4221136077 title "Muscle architecture, growth, and biological Remodelling in cerebral palsy: a narrative review" @default.
• W4221136077 cites W133820906 @default.
• W4221136077 cites W1482601876 @default.
• W4221136077 cites W1493182793 @default.
• W4221136077 cites W1519705923 @default.
• W4221136077 cites W1559509108 @default.
• W4221136077 cites W1569163094 @default.
• W4221136077 cites W1588644246 @default.
• W4221136077 cites W1590525238 @default.
• W4221136077 cites W1595606899 @default.
• W4221136077 cites W1607249625 @default.
• W4221136077 cites W1789856677 @default.
• W4221136077 cites W1838602924 @default.
• W4221136077 cites W1847176293 @default.
• W4221136077 cites W1948502073 @default.
• W4221136077 cites W1968325656 @default.
• W4221136077 cites W1970446505 @default.
• W4221136077 cites W1972072723 @default.
• W4221136077 cites W1972285843 @default.
• W4221136077 cites W1975229496 @default.
• W4221136077 cites W1976516551 @default.
• W4221136077 cites W1978710912 @default.
• W4221136077 cites W1979953919 @default.
• W4221136077 cites W1981478397 @default.
• W4221136077 cites W1984383186 @default.
• W4221136077 cites W1990155029 @default.
• W4221136077 cites W1991969441 @default.
• W4221136077 cites W1998108846 @default.
• W4221136077 cites W2000943144 @default.
• W4221136077 cites W2001070803 @default.
• W4221136077 cites W2002762002 @default.
• W4221136077 cites W2004229430 @default.
• W4221136077 cites W2004871261 @default.
• W4221136077 cites W2005366749 @default.
• W4221136077 cites W2006200504 @default.
• W4221136077 cites W2010741278 @default.
• W4221136077 cites W2010756008 @default.
• W4221136077 cites W2013369214 @default.
• W4221136077 cites W2013995821 @default.
• W4221136077 cites W2016242699 @default.
• W4221136077 cites W2017960653 @default.
• W4221136077 cites W2019904259 @default.
• W4221136077 cites W2021728570 @default.
• W4221136077 cites W2021993362 @default.
• W4221136077 cites W2022167001 @default.
• W4221136077 cites W2023457553 @default.
• W4221136077 cites W2025957803 @default.
• W4221136077 cites W2026040250 @default.
• W4221136077 cites W2030559868 @default.
• W4221136077 cites W2032410532 @default.
• W4221136077 cites W2040410295 @default.
• W4221136077 cites W2040873283 @default.
• W4221136077 cites W2043885413 @default.
• W4221136077 cites W2044522743 @default.
• W4221136077 cites W2044726084 @default.
• W4221136077 cites W2045295282 @default.
• W4221136077 cites W2050071332 @default.
• W4221136077 cites W2055782434 @default.
• W4221136077 cites W2057072817 @default.
• W4221136077 cites W2059897270 @default.
• W4221136077 cites W2059938268 @default.
• W4221136077 cites W2060570918 @default.
• W4221136077 cites W2060796520 @default.
• W4221136077 cites W2064619671 @default.
• W4221136077 cites W2073279228 @default.
• W4221136077 cites W2075366980 @default.
• W4221136077 cites W2075901884 @default.
• W4221136077 cites W2076230700 @default.
• W4221136077 cites W2077944281 @default.
• W4221136077 cites W2079350424 @default.
• W4221136077 cites W2084082271 @default.
• W4221136077 cites W2086389056 @default.
• W4221136077 cites W2088504513 @default.
• W4221136077 cites W2089636232 @default.
• W4221136077 cites W2092753921 @default.
• W4221136077 cites W2097808167 @default.
• W4221136077 cites W2098379227 @default.
• W4221136077 cites W2102142098 @default.
• W4221136077 cites W2105336663 @default.
• W4221136077 cites W2106212323 @default.
• W4221136077 cites W2108983717 @default.
• W4221136077 cites W2110488854 @default.
• W4221136077 cites W2111010630 @default.
• W4221136077 cites W2112286428 @default.
• W4221136077 cites W2116903115 @default.
• W4221136077 cites W2117658071 @default.
• W4221136077 cites W2118242556 @default.
• W4221136077 cites W2120182646 @default.
• W4221136077 cites W2121080731 @default.
• W4221136077 cites W2121559538 @default.
• W4221136077 cites W2123564531 @default.

• next