FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221138081> ?p ?o ?g. }

• W4221138081 endingPage "389" @default.
• W4221138081 startingPage "389" @default.
• W4221138081 abstract "Cerebral ischemia is related to insufficient blood supply and is characterized by abnormal reactive oxygen species (ROS) production and cell apoptosis. Previous studies have revealed a key role for basic helix-loop-helix family member e40 (Bhlhe40) in oxidative stress and cell apoptosis. This study aimed to investigate the roles of miR-494-3p in cerebral ischemia/reperfusion (I/R) injury.A mouse middle cerebral artery occlusion (MCAO/R) model was established to mimic cerebral ischemia in vivo. Brain infarct area was assessed using triphenyl tetrazolium chloride staining. Oxygen-glucose deprivation/reoxygenation (OGD/R) operation was adopted to mimic neuronal injury in vitro. Cell apoptosis was analyzed by flow cytometry. The relationship between miR-494-3p and Bhlhe40 was validated by luciferase reporter and RNA immunoprecipitation assays.Bhlhe40 expression was downregulated both in MCAO/R animal models and OGD/R-induced SH-SY5Y cells. Bhlhe40 overexpression inhibited cell apoptosis and reduced ROS production in SH-SY5Y cells after OGD/R treatment. MiR-494-3p was verified to bind to Bhlhe40 and negatively regulate Bhlhe40 expression. Additionally, cell apoptosis and ROS production in OGD/R-treated SH-SY5Y cells were accelerated by miR-494-3p overexpression. Rescue experiments suggested that Bhlhe40 could reverse the effects of miR-494-3p overexpression on ROS production and cell apoptosis.MiR-494-3p exacerbates brain injury and neuronal injury by regulating Bhlhe40 after I/R." @default.
• W4221138081 created "2022-04-03" @default.
• W4221138081 creator A5003199827 @default.
• W4221138081 creator A5004837413 @default.
• W4221138081 creator A5005028230 @default.
• W4221138081 creator A5006541265 @default.
• W4221138081 creator A5011970150 @default.
• W4221138081 creator A5019639457 @default.
• W4221138081 creator A5021284759 @default.
• W4221138081 creator A5046827489 @default.
• W4221138081 date "2022-01-01" @default.
• W4221138081 modified "2023-10-14" @default.
• W4221138081 title "MiR-494-3p Upregulation Exacerbates Cerebral Ischemia Injury by Targeting Bhlhe40" @default.
• W4221138081 cites W2007435978 @default.
• W4221138081 cites W2089505393 @default.
• W4221138081 cites W2099961758 @default.
• W4221138081 cites W2219670538 @default.
• W4221138081 cites W2289005142 @default.
• W4221138081 cites W2289016169 @default.
• W4221138081 cites W2545367885 @default.
• W4221138081 cites W2750839441 @default.
• W4221138081 cites W2887883056 @default.
• W4221138081 cites W2890766506 @default.
• W4221138081 cites W2890867569 @default.
• W4221138081 cites W2892293392 @default.
• W4221138081 cites W2899182295 @default.
• W4221138081 cites W2911336213 @default.
• W4221138081 cites W2911503339 @default.
• W4221138081 cites W2941002319 @default.
• W4221138081 cites W2942245752 @default.
• W4221138081 cites W2970212843 @default.
• W4221138081 cites W2972278523 @default.
• W4221138081 cites W2973063228 @default.
• W4221138081 cites W2978439222 @default.
• W4221138081 cites W2979294044 @default.
• W4221138081 cites W2981527185 @default.
• W4221138081 cites W2984638632 @default.
• W4221138081 cites W2985321231 @default.
• W4221138081 cites W2985343509 @default.
• W4221138081 cites W2985756491 @default.
• W4221138081 cites W2994167464 @default.
• W4221138081 doi "https://doi.org/10.3349/ymj.2022.63.4.389" @default.
• W4221138081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35352891" @default.
• W4221138081 hasPublicationYear "2022" @default.
• W4221138081 type Work @default.
• W4221138081 citedByCount "3" @default.
• W4221138081 countsByYear W42211380812022 @default.
• W4221138081 countsByYear W42211380812023 @default.
• W4221138081 crossrefType "journal-article" @default.
• W4221138081 hasAuthorship W4221138081A5003199827 @default.
• W4221138081 hasAuthorship W4221138081A5004837413 @default.
• W4221138081 hasAuthorship W4221138081A5005028230 @default.
• W4221138081 hasAuthorship W4221138081A5006541265 @default.
• W4221138081 hasAuthorship W4221138081A5011970150 @default.
• W4221138081 hasAuthorship W4221138081A5019639457 @default.
• W4221138081 hasAuthorship W4221138081A5021284759 @default.
• W4221138081 hasAuthorship W4221138081A5046827489 @default.
• W4221138081 hasBestOaLocation W42211380811 @default.
• W4221138081 hasConcept C104317684 @default.
• W4221138081 hasConcept C126322002 @default.
• W4221138081 hasConcept C127561419 @default.
• W4221138081 hasConcept C153911025 @default.
• W4221138081 hasConcept C185592680 @default.
• W4221138081 hasConcept C190283241 @default.
• W4221138081 hasConcept C2776151105 @default.
• W4221138081 hasConcept C2778820722 @default.
• W4221138081 hasConcept C2780114680 @default.
• W4221138081 hasConcept C48349386 @default.
• W4221138081 hasConcept C541997718 @default.
• W4221138081 hasConcept C553184892 @default.
• W4221138081 hasConcept C55493867 @default.
• W4221138081 hasConcept C71924100 @default.
• W4221138081 hasConcept C86803240 @default.
• W4221138081 hasConcept C95444343 @default.
• W4221138081 hasConceptScore W4221138081C104317684 @default.
• W4221138081 hasConceptScore W4221138081C126322002 @default.
• W4221138081 hasConceptScore W4221138081C127561419 @default.
• W4221138081 hasConceptScore W4221138081C153911025 @default.
• W4221138081 hasConceptScore W4221138081C185592680 @default.
• W4221138081 hasConceptScore W4221138081C190283241 @default.
• W4221138081 hasConceptScore W4221138081C2776151105 @default.
• W4221138081 hasConceptScore W4221138081C2778820722 @default.
• W4221138081 hasConceptScore W4221138081C2780114680 @default.
• W4221138081 hasConceptScore W4221138081C48349386 @default.
• W4221138081 hasConceptScore W4221138081C541997718 @default.
• W4221138081 hasConceptScore W4221138081C553184892 @default.
• W4221138081 hasConceptScore W4221138081C55493867 @default.
• W4221138081 hasConceptScore W4221138081C71924100 @default.
• W4221138081 hasConceptScore W4221138081C86803240 @default.
• W4221138081 hasConceptScore W4221138081C95444343 @default.
• W4221138081 hasIssue "4" @default.
• W4221138081 hasLocation W42211380811 @default.
• W4221138081 hasLocation W42211380812 @default.
• W4221138081 hasLocation W42211380813 @default.
• W4221138081 hasOpenAccess W4221138081 @default.
• W4221138081 hasPrimaryLocation W42211380811 @default.
• W4221138081 hasRelatedWork W2061260890 @default.
• W4221138081 hasRelatedWork W2164509469 @default.

• next