FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223415304> ?p ?o ?g. }

• W4223415304 endingPage "1706" @default.
• W4223415304 startingPage "1693" @default.
• W4223415304 abstract "Cerebral blood flow is a finely tuned process dependent on coordinated changes in arterial tone. These changes are strongly tied to smooth muscle membrane potential and inwardly rectifying K + (K IR ) channels are thought to be a key determinant. To elucidate the role of K IR 2.1 in cerebral arterial tone development, this study examined the electrical and functional properties of cells, vessels and living tissue from tamoxifen-induced smooth muscle cell (SMC)-specific K IR 2.1 knockout mice. Patch-clamp electrophysiology revealed a robust Ba 2+ -sensitive inwardly rectifying K + current in cerebral arterial myocytes irrespective of K IR 2.1 knockout. Immunolabeling clarified that K IR 2.1 expression was low in SMCs while K IR 2.2 labeling was remarkably abundant at the membrane. In alignment with these observations, pressure myography revealed that the myogenic response and K + -induced dilation were intact in cerebral arteries post knockout. At the whole organ level, this translated to a maintenance of brain perfusion in SMC K IR 2.1 −/− mice, as assessed with arterial spin-labeling MRI. We confirmed these findings in superior epigastric arteries and implicated K IR 2.2 as more functionally relevant in SMCs. Together, these results suggest that subunits other than K IR 2.1 play a significant role in setting native current in SMCs and driving arterial tone." @default.
• W4223415304 created "2022-04-14" @default.
• W4223415304 creator A5003505683 @default.
• W4223415304 creator A5012359883 @default.
• W4223415304 creator A5015614234 @default.
• W4223415304 creator A5017999721 @default.
• W4223415304 creator A5033448990 @default.
• W4223415304 creator A5033670666 @default.
• W4223415304 creator A5039257890 @default.
• W4223415304 creator A5048090770 @default.
• W4223415304 creator A5064444855 @default.
• W4223415304 creator A5068389319 @default.
• W4223415304 creator A5088536388 @default.
• W4223415304 date "2022-04-11" @default.
• W4223415304 modified "2023-10-09" @default.
• W4223415304 title "Genetic ablation of smooth muscle K_IR2.1 is inconsequential to the function of mouse cerebral arteries" @default.
• W4223415304 cites W1481644799 @default.
• W4223415304 cites W1575129867 @default.
• W4223415304 cites W1753089048 @default.
• W4223415304 cites W1901856024 @default.
• W4223415304 cites W1979089605 @default.
• W4223415304 cites W1993130354 @default.
• W4223415304 cites W2019832656 @default.
• W4223415304 cites W2020169158 @default.
• W4223415304 cites W2021724833 @default.
• W4223415304 cites W2024579981 @default.
• W4223415304 cites W2029728688 @default.
• W4223415304 cites W2039412500 @default.
• W4223415304 cites W2049069390 @default.
• W4223415304 cites W2058747402 @default.
• W4223415304 cites W2073218614 @default.
• W4223415304 cites W2079934771 @default.
• W4223415304 cites W2081709819 @default.
• W4223415304 cites W2094270473 @default.
• W4223415304 cites W2095800632 @default.
• W4223415304 cites W2107826105 @default.
• W4223415304 cites W2112696231 @default.
• W4223415304 cites W2118644794 @default.
• W4223415304 cites W2121399400 @default.
• W4223415304 cites W2129305652 @default.
• W4223415304 cites W2129433521 @default.
• W4223415304 cites W2129569249 @default.
• W4223415304 cites W2156600279 @default.
• W4223415304 cites W2161227647 @default.
• W4223415304 cites W2171490077 @default.
• W4223415304 cites W2257854023 @default.
• W4223415304 cites W2395707267 @default.
• W4223415304 cites W2602561729 @default.
• W4223415304 cites W2607057358 @default.
• W4223415304 cites W2618797434 @default.
• W4223415304 cites W2732681243 @default.
• W4223415304 cites W2786318872 @default.
• W4223415304 cites W2888209830 @default.
• W4223415304 cites W2918288555 @default.
• W4223415304 cites W2950379196 @default.
• W4223415304 cites W2996907168 @default.
• W4223415304 cites W4296816736 @default.
• W4223415304 doi "https://doi.org/10.1177/0271678x221093432" @default.
• W4223415304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35410518" @default.
• W4223415304 hasPublicationYear "2022" @default.
• W4223415304 type Work @default.
• W4223415304 citedByCount "4" @default.
• W4223415304 countsByYear W42234153042023 @default.
• W4223415304 crossrefType "journal-article" @default.
• W4223415304 hasAuthorship W4223415304A5003505683 @default.
• W4223415304 hasAuthorship W4223415304A5012359883 @default.
• W4223415304 hasAuthorship W4223415304A5015614234 @default.
• W4223415304 hasAuthorship W4223415304A5017999721 @default.
• W4223415304 hasAuthorship W4223415304A5033448990 @default.
• W4223415304 hasAuthorship W4223415304A5033670666 @default.
• W4223415304 hasAuthorship W4223415304A5039257890 @default.
• W4223415304 hasAuthorship W4223415304A5048090770 @default.
• W4223415304 hasAuthorship W4223415304A5064444855 @default.
• W4223415304 hasAuthorship W4223415304A5068389319 @default.
• W4223415304 hasAuthorship W4223415304A5088536388 @default.
• W4223415304 hasBestOaLocation W42234153041 @default.
• W4223415304 hasConcept C105702510 @default.
• W4223415304 hasConcept C120770815 @default.
• W4223415304 hasConcept C126322002 @default.
• W4223415304 hasConcept C134018914 @default.
• W4223415304 hasConcept C147944092 @default.
• W4223415304 hasConcept C169760540 @default.
• W4223415304 hasConcept C170493617 @default.
• W4223415304 hasConcept C171614378 @default.
• W4223415304 hasConcept C182704531 @default.
• W4223415304 hasConcept C185263204 @default.
• W4223415304 hasConcept C185592680 @default.
• W4223415304 hasConcept C1918360 @default.
• W4223415304 hasConcept C204232928 @default.
• W4223415304 hasConcept C207200792 @default.
• W4223415304 hasConcept C2777877921 @default.
• W4223415304 hasConcept C2992686903 @default.
• W4223415304 hasConcept C58336856 @default.
• W4223415304 hasConcept C71924100 @default.
• W4223415304 hasConcept C86803240 @default.
• W4223415304 hasConceptScore W4223415304C105702510 @default.
• W4223415304 hasConceptScore W4223415304C120770815 @default.
• W4223415304 hasConceptScore W4223415304C126322002 @default.

• next