FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223418055> ?p ?o ?g. }

• W4223418055 abstract "Abstract Antimicrobial resistance poses a rising threat to global health, making it crucial to understand the routes of bacterial survival during antimicrobial treatments. Treatment failure can result from genetic or phenotypic mechanisms, which diminish the effect of antibiotics. By assembling empirical data, we find that, for example, Pseudomonas aeruginosa infections in cystic fibrosis patients frequently contain persisters, transiently non-growing and antibiotic-refractory subpopulations, and hyper-mutators, mutants with elevated mutation rates and thus higher probability of genetic resistance emergence. Resistance, persistence and hyper-mutation dynamics are difficult to disentangle experimentally. Hence, we use stochastic population modelling and deterministic fitness calculations of bacterial evolution under antibiotic treatment to investigate how genetic resistance and phenotypic mechanisms affect treatment success. We find that treatment failure is caused by resistant mutants at lower antibiotic concentrations (with high final bacterial numbers), but by persistence phenotypes at higher antibiotic concentrations (with low final bacterial numbers). Facilitation of resistance occurs through hyper-mutators during treatment, but through persistence only after treatment is discontinued, which allows for persisters to resume growth and evolve resistance in the absence of antibiotics. Our findings highlight the time- and concentration-dependence of different bacterial mechanisms to escape antibiotic killing, which should be considered when designing ‘resistance-proof’ antimicrobial treatments." @default.
• W4223418055 created "2022-04-14" @default.
• W4223418055 creator A5009994638 @default.
• W4223418055 creator A5037513292 @default.
• W4223418055 creator A5063648384 @default.
• W4223418055 date "2022-04-09" @default.
• W4223418055 modified "2023-10-14" @default.
• W4223418055 title "Assessing the importance of resistance, persistence and hyper-mutation for antibiotic treatment success with stochastic modelling" @default.
• W4223418055 cites W1511667485 @default.
• W4223418055 cites W1527303322 @default.
• W4223418055 cites W1810815273 @default.
• W4223418055 cites W1899580745 @default.
• W4223418055 cites W1971937804 @default.
• W4223418055 cites W1972510216 @default.
• W4223418055 cites W1972847233 @default.
• W4223418055 cites W1984876660 @default.
• W4223418055 cites W1985687704 @default.
• W4223418055 cites W2019385975 @default.
• W4223418055 cites W2035226835 @default.
• W4223418055 cites W2039554211 @default.
• W4223418055 cites W2046997536 @default.
• W4223418055 cites W2081834615 @default.
• W4223418055 cites W2091301347 @default.
• W4223418055 cites W2095833414 @default.
• W4223418055 cites W2100053975 @default.
• W4223418055 cites W2101366952 @default.
• W4223418055 cites W2102614752 @default.
• W4223418055 cites W2106391833 @default.
• W4223418055 cites W2107600014 @default.
• W4223418055 cites W2115712103 @default.
• W4223418055 cites W2116043017 @default.
• W4223418055 cites W2119803749 @default.
• W4223418055 cites W2121628360 @default.
• W4223418055 cites W2126490800 @default.
• W4223418055 cites W2127240867 @default.
• W4223418055 cites W2130091893 @default.
• W4223418055 cites W2134542631 @default.
• W4223418055 cites W2137761651 @default.
• W4223418055 cites W2146761052 @default.
• W4223418055 cites W2148323109 @default.
• W4223418055 cites W2155770029 @default.
• W4223418055 cites W2155985488 @default.
• W4223418055 cites W2163856333 @default.
• W4223418055 cites W2164003656 @default.
• W4223418055 cites W2164057520 @default.
• W4223418055 cites W2169053394 @default.
• W4223418055 cites W2314754341 @default.
• W4223418055 cites W2319149979 @default.
• W4223418055 cites W2566432881 @default.
• W4223418055 cites W2586590237 @default.
• W4223418055 cites W2737156317 @default.
• W4223418055 cites W2737684804 @default.
• W4223418055 cites W2754684752 @default.
• W4223418055 cites W2767034994 @default.
• W4223418055 cites W2792631429 @default.
• W4223418055 cites W2796472927 @default.
• W4223418055 cites W2910584283 @default.
• W4223418055 cites W2913241312 @default.
• W4223418055 cites W2940117744 @default.
• W4223418055 cites W2950298536 @default.
• W4223418055 cites W2955249862 @default.
• W4223418055 cites W2988132875 @default.
• W4223418055 cites W2995568032 @default.
• W4223418055 cites W3048430064 @default.
• W4223418055 cites W3112994300 @default.
• W4223418055 cites W3144935023 @default.
• W4223418055 cites W3203916352 @default.
• W4223418055 cites W4206677002 @default.
• W4223418055 cites W4213353716 @default.
• W4223418055 doi "https://doi.org/10.1101/2022.04.07.487440" @default.
• W4223418055 hasPublicationYear "2022" @default.
• W4223418055 type Work @default.
• W4223418055 citedByCount "1" @default.
• W4223418055 countsByYear W42234180552022 @default.
• W4223418055 crossrefType "posted-content" @default.
• W4223418055 hasAuthorship W4223418055A5009994638 @default.
• W4223418055 hasAuthorship W4223418055A5037513292 @default.
• W4223418055 hasAuthorship W4223418055A5063648384 @default.
• W4223418055 hasBestOaLocation W42234180551 @default.
• W4223418055 hasConcept C104317684 @default.
• W4223418055 hasConcept C127413603 @default.
• W4223418055 hasConcept C127716648 @default.
• W4223418055 hasConcept C136622501 @default.
• W4223418055 hasConcept C187320778 @default.
• W4223418055 hasConcept C2777637488 @default.
• W4223418055 hasConcept C2781009140 @default.
• W4223418055 hasConcept C2908647359 @default.
• W4223418055 hasConcept C4937899 @default.
• W4223418055 hasConcept C501593827 @default.
• W4223418055 hasConcept C501734568 @default.
• W4223418055 hasConcept C523546767 @default.
• W4223418055 hasConcept C54355233 @default.
• W4223418055 hasConcept C58123911 @default.
• W4223418055 hasConcept C71924100 @default.
• W4223418055 hasConcept C86803240 @default.
• W4223418055 hasConcept C89423630 @default.
• W4223418055 hasConcept C94665300 @default.
• W4223418055 hasConcept C99454951 @default.
• W4223418055 hasConceptScore W4223418055C104317684 @default.
• W4223418055 hasConceptScore W4223418055C127413603 @default.

• next