Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223429195> ?p ?o ?g. }
- W4223429195 abstract "With the rapid development of high-throughput sequencing technology, approaches for assessing biological ingredients in Traditional Chinese Medicine (TCM) preparations have also advanced. Using a multi-barcode sequencing approach, all biological ingredients could be identified from TCM preparations in theory, as long as their DNA is present. The biological ingredients of several classical TCM preparations were analyzed successfully based on this approach in previous studies. However, the universality, sensitivity and reliability of this approach on a diverse set of TCM preparations remain unclear. In this study, we selected four representative TCM preparations, namely Bazhen Yimu Wan, Da Huoluo Wan, Niuhuang Jiangya Wan, and You Gui Wan, for concrete assessment of the multi-barcode sequencing approach. Based on ITS2 and trnL biomarkers, we have successfully detected the prescribed herbal materials (PHMs) in these representative TCM preparations (minimum sensitivity: 77.8%, maximum sensitivity: 100%). The results based on ITS2 have also shown higher reliability than trnL at species level, while their combination could provide higher sensitivity and reliability. The multi-barcode sequencing approach has shown good universality, sensitivity and reliability in decoding these four representative TCM preparations. In the omics big-data era, this work has undoubtedly made one step forward for applying multi-barcode sequencing approach in PHMs analysis of TCM preparation, towards better digitization and modernization of drug quality control." @default.
- W4223429195 created "2022-04-14" @default.
- W4223429195 creator A5000432967 @default.
- W4223429195 creator A5005707695 @default.
- W4223429195 creator A5043281478 @default.
- W4223429195 creator A5043800500 @default.
- W4223429195 creator A5071962600 @default.
- W4223429195 creator A5076346443 @default.
- W4223429195 creator A5086445793 @default.
- W4223429195 date "2022-04-09" @default.
- W4223429195 modified "2023-09-30" @default.
- W4223429195 title "Decoding herbal materials of TCM preparations with the multi-barcode sequencing approach" @default.
- W4223429195 cites W1972486877 @default.
- W4223429195 cites W1974412051 @default.
- W4223429195 cites W1977167384 @default.
- W4223429195 cites W1981839438 @default.
- W4223429195 cites W2007114536 @default.
- W4223429195 cites W2007418597 @default.
- W4223429195 cites W2016650704 @default.
- W4223429195 cites W2016771310 @default.
- W4223429195 cites W2023356179 @default.
- W4223429195 cites W2033975546 @default.
- W4223429195 cites W2035159051 @default.
- W4223429195 cites W2035872451 @default.
- W4223429195 cites W2055822764 @default.
- W4223429195 cites W2064173452 @default.
- W4223429195 cites W2067936850 @default.
- W4223429195 cites W2070991780 @default.
- W4223429195 cites W2075128964 @default.
- W4223429195 cites W2081422634 @default.
- W4223429195 cites W2081477370 @default.
- W4223429195 cites W2081653606 @default.
- W4223429195 cites W2093058617 @default.
- W4223429195 cites W2093296928 @default.
- W4223429195 cites W2098244304 @default.
- W4223429195 cites W2099901798 @default.
- W4223429195 cites W2108718991 @default.
- W4223429195 cites W2128188644 @default.
- W4223429195 cites W2133856765 @default.
- W4223429195 cites W2138273629 @default.
- W4223429195 cites W2140150603 @default.
- W4223429195 cites W2154053567 @default.
- W4223429195 cites W2157825442 @default.
- W4223429195 cites W2159675211 @default.
- W4223429195 cites W2205448235 @default.
- W4223429195 cites W2226712345 @default.
- W4223429195 cites W2334939036 @default.
- W4223429195 cites W2355973776 @default.
- W4223429195 cites W2388091575 @default.
- W4223429195 cites W2412988523 @default.
- W4223429195 cites W2415603434 @default.
- W4223429195 cites W2422292098 @default.
- W4223429195 cites W2465946406 @default.
- W4223429195 cites W2618774403 @default.
- W4223429195 cites W2768069935 @default.
- W4223429195 cites W2802292882 @default.
- W4223429195 cites W2901065507 @default.
- W4223429195 cites W2937364244 @default.
- W4223429195 cites W2999018058 @default.
- W4223429195 cites W3010497490 @default.
- W4223429195 cites W3012019387 @default.
- W4223429195 cites W3020870550 @default.
- W4223429195 cites W3021247069 @default.
- W4223429195 cites W3037458030 @default.
- W4223429195 cites W3197934056 @default.
- W4223429195 cites W4237095724 @default.
- W4223429195 cites W4247964656 @default.
- W4223429195 cites W994818366 @default.
- W4223429195 doi "https://doi.org/10.1038/s41598-022-09979-z" @default.
- W4223429195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35397643" @default.
- W4223429195 hasPublicationYear "2022" @default.
- W4223429195 type Work @default.
- W4223429195 citedByCount "9" @default.
- W4223429195 countsByYear W42234291952022 @default.
- W4223429195 countsByYear W42234291952023 @default.
- W4223429195 crossrefType "journal-article" @default.
- W4223429195 hasAuthorship W4223429195A5000432967 @default.
- W4223429195 hasAuthorship W4223429195A5005707695 @default.
- W4223429195 hasAuthorship W4223429195A5043281478 @default.
- W4223429195 hasAuthorship W4223429195A5043800500 @default.
- W4223429195 hasAuthorship W4223429195A5071962600 @default.
- W4223429195 hasAuthorship W4223429195A5076346443 @default.
- W4223429195 hasAuthorship W4223429195A5086445793 @default.
- W4223429195 hasBestOaLocation W42234291951 @default.
- W4223429195 hasConcept C111919701 @default.
- W4223429195 hasConcept C121332964 @default.
- W4223429195 hasConcept C163258240 @default.
- W4223429195 hasConcept C2776841711 @default.
- W4223429195 hasConcept C41008148 @default.
- W4223429195 hasConcept C43214815 @default.
- W4223429195 hasConcept C51679486 @default.
- W4223429195 hasConcept C54355233 @default.
- W4223429195 hasConcept C552990157 @default.
- W4223429195 hasConcept C556039675 @default.
- W4223429195 hasConcept C62520636 @default.
- W4223429195 hasConcept C70721500 @default.
- W4223429195 hasConcept C71924100 @default.
- W4223429195 hasConcept C86803240 @default.
- W4223429195 hasConceptScore W4223429195C111919701 @default.
- W4223429195 hasConceptScore W4223429195C121332964 @default.