Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223430248> ?p ?o ?g. }
- W4223430248 abstract "Hypophysiotropic somatostatin (SST) neurons in the periventricular hypothalamic area express growth hormone (GH) receptor (GHR) and are frequently considered as the key neuronal population that mediates the negative feedback loop controlling the hypothalamic-GH axis. Additionally, insulin-like growth factor-1 (IGF-1) may also act at the hypothalamic level to control pituitary GH secretion via long-loop negative feedback. However, to the best of our knowledge, no study so far has tested whether GHR or IGF-1 receptor (IGF1R) signaling specifically in SST neurons is required for the homeostatic control of GH secretion. Here we show that GHR ablation in SST neurons did not impact the negative feedback mechanisms that control pulsatile GH secretion or body growth in male and female mice. The sex difference in hepatic gene expression profile was only mildly affected by GHR ablation in SST neurons. Similarly, IGF1R ablation in SST neurons did not affect pulsatile GH secretion, body growth, or hepatic gene expression. In contrast, simultaneous ablation of both GHR and IGF1R in SST-expressing cells increased mean GH levels and pulse amplitude in male and female mice, and partially disrupted the sex differences in hepatic gene expression. Despite the increased GH secretion in double knockout mice, no alterations in body growth and serum or liver IGF-1 levels were observed. In summary, GHR and IGF1R signaling in SST neurons play a redundant role in the control of GH secretion. Furthermore, our results reveal the importance of GH/IGF-1 negative feedback mechanisms on SST neurons for the establishment of sex differences in hepatic gene expression profile." @default.
- W4223430248 created "2022-04-14" @default.
- W4223430248 creator A5002808324 @default.
- W4223430248 creator A5004533621 @default.
- W4223430248 creator A5006327283 @default.
- W4223430248 creator A5039561248 @default.
- W4223430248 creator A5049376076 @default.
- W4223430248 creator A5054006122 @default.
- W4223430248 creator A5065229869 @default.
- W4223430248 creator A5065949524 @default.
- W4223430248 creator A5067315285 @default.
- W4223430248 creator A5068579361 @default.
- W4223430248 creator A5085412418 @default.
- W4223430248 creator A5086183352 @default.
- W4223430248 creator A5091177547 @default.
- W4223430248 date "2022-04-08" @default.
- W4223430248 modified "2023-10-15" @default.
- W4223430248 title "Effects of the Isolated and Combined Ablation of Growth Hormone and IGF-1 Receptors in Somatostatin Neurons" @default.
- W4223430248 cites W1726025741 @default.
- W4223430248 cites W1870545401 @default.
- W4223430248 cites W1898141713 @default.
- W4223430248 cites W1914406040 @default.
- W4223430248 cites W1965699720 @default.
- W4223430248 cites W1967468456 @default.
- W4223430248 cites W1971857747 @default.
- W4223430248 cites W1974228571 @default.
- W4223430248 cites W1981736657 @default.
- W4223430248 cites W1986441153 @default.
- W4223430248 cites W1990095603 @default.
- W4223430248 cites W2004053614 @default.
- W4223430248 cites W2007570747 @default.
- W4223430248 cites W2008829664 @default.
- W4223430248 cites W2022212375 @default.
- W4223430248 cites W2025557439 @default.
- W4223430248 cites W2026307684 @default.
- W4223430248 cites W2029910779 @default.
- W4223430248 cites W2030729252 @default.
- W4223430248 cites W2031207165 @default.
- W4223430248 cites W2051663587 @default.
- W4223430248 cites W2055192686 @default.
- W4223430248 cites W2062687197 @default.
- W4223430248 cites W2078220496 @default.
- W4223430248 cites W2078897694 @default.
- W4223430248 cites W2082880407 @default.
- W4223430248 cites W2083154021 @default.
- W4223430248 cites W2083851666 @default.
- W4223430248 cites W2086148263 @default.
- W4223430248 cites W2088412664 @default.
- W4223430248 cites W2091837377 @default.
- W4223430248 cites W2095098999 @default.
- W4223430248 cites W2097129409 @default.
- W4223430248 cites W2108084238 @default.
- W4223430248 cites W2112875099 @default.
- W4223430248 cites W2116623369 @default.
- W4223430248 cites W2122767257 @default.
- W4223430248 cites W2140112176 @default.
- W4223430248 cites W2147709636 @default.
- W4223430248 cites W2149883903 @default.
- W4223430248 cites W2149985387 @default.
- W4223430248 cites W2153772986 @default.
- W4223430248 cites W2156424672 @default.
- W4223430248 cites W2167353083 @default.
- W4223430248 cites W2198101323 @default.
- W4223430248 cites W2337477903 @default.
- W4223430248 cites W2396044725 @default.
- W4223430248 cites W2413465374 @default.
- W4223430248 cites W2529998943 @default.
- W4223430248 cites W2642147666 @default.
- W4223430248 cites W2787947617 @default.
- W4223430248 cites W2789677699 @default.
- W4223430248 cites W3017055040 @default.
- W4223430248 cites W3096386534 @default.
- W4223430248 cites W3120430494 @default.
- W4223430248 cites W3161267406 @default.
- W4223430248 doi "https://doi.org/10.1210/endocr/bqac045" @default.
- W4223430248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35395079" @default.
- W4223430248 hasPublicationYear "2022" @default.
- W4223430248 type Work @default.
- W4223430248 citedByCount "10" @default.
- W4223430248 countsByYear W42234302482022 @default.
- W4223430248 countsByYear W42234302482023 @default.
- W4223430248 crossrefType "journal-article" @default.
- W4223430248 hasAuthorship W4223430248A5002808324 @default.
- W4223430248 hasAuthorship W4223430248A5004533621 @default.
- W4223430248 hasAuthorship W4223430248A5006327283 @default.
- W4223430248 hasAuthorship W4223430248A5039561248 @default.
- W4223430248 hasAuthorship W4223430248A5049376076 @default.
- W4223430248 hasAuthorship W4223430248A5054006122 @default.
- W4223430248 hasAuthorship W4223430248A5065229869 @default.
- W4223430248 hasAuthorship W4223430248A5065949524 @default.
- W4223430248 hasAuthorship W4223430248A5067315285 @default.
- W4223430248 hasAuthorship W4223430248A5068579361 @default.
- W4223430248 hasAuthorship W4223430248A5085412418 @default.
- W4223430248 hasAuthorship W4223430248A5086183352 @default.
- W4223430248 hasAuthorship W4223430248A5091177547 @default.
- W4223430248 hasBestOaLocation W42234302481 @default.
- W4223430248 hasConcept C113675107 @default.
- W4223430248 hasConcept C126322002 @default.
- W4223430248 hasConcept C134018914 @default.
- W4223430248 hasConcept C144174609 @default.