Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223436437> ?p ?o ?g. }
- W4223436437 endingPage "100622" @default.
- W4223436437 startingPage "100622" @default.
- W4223436437 abstract "Binding-induced fibrillogenesis (BIF) peptides have a promising future in biomedicine due to the processiblity in situ in vivo, which bind to a specific trigger and in situ self-assemble into nanofibrous structures (BIF process) with excellent physical/biological functions. Alkyl chains in BIF peptides as hydrophobic tails have an important effect on self-assembly behaviors of BIF peptides. Herein, BIF peptides (trigger: Ca2+ or integrin) with different hydrophobic alkyl chains are designed to explore the influence of hydrophobicity on self-assembly behaviors of BIF peptides (Abbreviation as BIF4, BIF8, and BIF16 for 4, 8, 16 carbons of alkyl chains). It is found that BIF peptides with weak hydrophobicity (BIF4) do not form fibrous structure upon binding to Ca2+, but in nanoparticle formulation. While with strong hydrophobicity, BIF16 initially self-assemble into nanoparticles, which further bind to Ca2+ and self-assemble into nanofibers with a β-sheet conformation. As a result, when incubated with HUVECs overexpressing integrins on surfaces, BIF4 were internalized as nanoparticles without BIF process, but BIF16 performed BIF process and attached on cell surfaces. This study provides experimental evidences of the hydrophobicity effect on self-assembly behavior of BIF peptides and directs applications of BIF peptides with controllable self-assembly" @default.
- W4223436437 created "2022-04-14" @default.
- W4223436437 creator A5003464331 @default.
- W4223436437 creator A5020694867 @default.
- W4223436437 creator A5073216396 @default.
- W4223436437 creator A5073848103 @default.
- W4223436437 creator A5076403164 @default.
- W4223436437 creator A5081229366 @default.
- W4223436437 date "2022-05-01" @default.
- W4223436437 modified "2023-09-30" @default.
- W4223436437 title "Hydrophobicity regulates self-assembly behavior of binding-induced fibrillogenesis peptides" @default.
- W4223436437 cites W1751375628 @default.
- W4223436437 cites W1969720998 @default.
- W4223436437 cites W1976915573 @default.
- W4223436437 cites W1994486848 @default.
- W4223436437 cites W1999002525 @default.
- W4223436437 cites W2035824721 @default.
- W4223436437 cites W2039973618 @default.
- W4223436437 cites W2066767743 @default.
- W4223436437 cites W2091355622 @default.
- W4223436437 cites W2123692136 @default.
- W4223436437 cites W2137790756 @default.
- W4223436437 cites W2148820085 @default.
- W4223436437 cites W2323245805 @default.
- W4223436437 cites W2469926842 @default.
- W4223436437 cites W2477636673 @default.
- W4223436437 cites W2588186041 @default.
- W4223436437 cites W2601217965 @default.
- W4223436437 cites W2623609137 @default.
- W4223436437 cites W2790248187 @default.
- W4223436437 cites W2799316847 @default.
- W4223436437 cites W2808425073 @default.
- W4223436437 cites W2817784260 @default.
- W4223436437 cites W2888790578 @default.
- W4223436437 cites W2914179168 @default.
- W4223436437 cites W2935957247 @default.
- W4223436437 cites W2938383164 @default.
- W4223436437 cites W2977177779 @default.
- W4223436437 cites W2986244674 @default.
- W4223436437 cites W3020242379 @default.
- W4223436437 cites W3024240904 @default.
- W4223436437 cites W3024728680 @default.
- W4223436437 cites W3084288334 @default.
- W4223436437 cites W3093360248 @default.
- W4223436437 cites W3122087776 @default.
- W4223436437 cites W3126344576 @default.
- W4223436437 cites W3176747598 @default.
- W4223436437 cites W3183571631 @default.
- W4223436437 cites W3196009935 @default.
- W4223436437 cites W3204254871 @default.
- W4223436437 cites W4200226032 @default.
- W4223436437 cites W4239858085 @default.
- W4223436437 doi "https://doi.org/10.1016/j.colcom.2022.100622" @default.
- W4223436437 hasPublicationYear "2022" @default.
- W4223436437 type Work @default.
- W4223436437 citedByCount "1" @default.
- W4223436437 countsByYear W42234364372023 @default.
- W4223436437 crossrefType "journal-article" @default.
- W4223436437 hasAuthorship W4223436437A5003464331 @default.
- W4223436437 hasAuthorship W4223436437A5020694867 @default.
- W4223436437 hasAuthorship W4223436437A5073216396 @default.
- W4223436437 hasAuthorship W4223436437A5073848103 @default.
- W4223436437 hasAuthorship W4223436437A5076403164 @default.
- W4223436437 hasAuthorship W4223436437A5081229366 @default.
- W4223436437 hasBestOaLocation W42234364371 @default.
- W4223436437 hasConcept C12554922 @default.
- W4223436437 hasConcept C147259501 @default.
- W4223436437 hasConcept C155672457 @default.
- W4223436437 hasConcept C171250308 @default.
- W4223436437 hasConcept C178790620 @default.
- W4223436437 hasConcept C185592680 @default.
- W4223436437 hasConcept C192562407 @default.
- W4223436437 hasConcept C26856880 @default.
- W4223436437 hasConcept C27523624 @default.
- W4223436437 hasConcept C2779281246 @default.
- W4223436437 hasConcept C2780263894 @default.
- W4223436437 hasConcept C55493867 @default.
- W4223436437 hasConcept C86803240 @default.
- W4223436437 hasConcept C90260826 @default.
- W4223436437 hasConceptScore W4223436437C12554922 @default.
- W4223436437 hasConceptScore W4223436437C147259501 @default.
- W4223436437 hasConceptScore W4223436437C155672457 @default.
- W4223436437 hasConceptScore W4223436437C171250308 @default.
- W4223436437 hasConceptScore W4223436437C178790620 @default.
- W4223436437 hasConceptScore W4223436437C185592680 @default.
- W4223436437 hasConceptScore W4223436437C192562407 @default.
- W4223436437 hasConceptScore W4223436437C26856880 @default.
- W4223436437 hasConceptScore W4223436437C27523624 @default.
- W4223436437 hasConceptScore W4223436437C2779281246 @default.
- W4223436437 hasConceptScore W4223436437C2780263894 @default.
- W4223436437 hasConceptScore W4223436437C55493867 @default.
- W4223436437 hasConceptScore W4223436437C86803240 @default.
- W4223436437 hasConceptScore W4223436437C90260826 @default.
- W4223436437 hasFunder F4320321001 @default.
- W4223436437 hasLocation W42234364371 @default.
- W4223436437 hasOpenAccess W4223436437 @default.
- W4223436437 hasPrimaryLocation W42234364371 @default.
- W4223436437 hasRelatedWork W1977839786 @default.