FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223440166> ?p ?o ?g. }

• W4223440166 endingPage "4435" @default.
• W4223440166 startingPage "4421" @default.
• W4223440166 abstract "Abstract Duchenne muscular dystrophy (DMD) is a progressive, neuromuscular disorder caused by mutations in the DMD gene that results in a lack of functional dystrophin protein. Herein, we report the use of quantitative magnetic resonance imaging (MRI) measures as biomarkers in the context of a multicenter phase 2, randomized, placebo-controlled clinical trial evaluating the myostatin inhibitor domagrozumab in ambulatory boys with DMD ( n = 120 aged 6 to < 16 years). MRI scans of the thigh to measure muscle volume, muscle volume index (MVI), fat fraction, and T2 relaxation time were obtained at baseline and at weeks 17, 33, 49, and 97 as per protocol. These quantitative MRI measurements appeared to be sensitive and objective biomarkers for evaluating disease progression, with significant changes observed in muscle volume, MVI, and T2 mapping measures over time. To further explore the utility of quantitative MRI measures as biomarkers to inform longer term functional changes in this cohort, a regression analysis was performed and demonstrated that muscle volume, MVI, T2 mapping measures, and fat fraction assessment were significantly correlated with longer term changes in four-stair climb times and North Star Ambulatory Assessment functional scores. Finally, less favorable baseline measures of MVI, fat fraction of the muscle bundle, and fat fraction of lean muscle were significant risk factors for loss of ambulation over a 2-year monitoring period. These analyses suggest that MRI can be a valuable tool for use in clinical trials and may help inform future functional changes in DMD. Trial registration: ClinicalTrials.gov identifier, NCT02310763; registered December 2014." @default.
• W4223440166 created "2022-04-14" @default.
• W4223440166 creator A5002197436 @default.
• W4223440166 creator A5007427947 @default.
• W4223440166 creator A5012227405 @default.
• W4223440166 creator A5015956195 @default.
• W4223440166 creator A5020829434 @default.
• W4223440166 creator A5024414333 @default.
• W4223440166 creator A5040386348 @default.
• W4223440166 creator A5046308926 @default.
• W4223440166 creator A5062032887 @default.
• W4223440166 creator A5063362332 @default.
• W4223440166 creator A5071163954 @default.
• W4223440166 creator A5078152396 @default.
• W4223440166 creator A5081817483 @default.
• W4223440166 creator A5085970575 @default.
• W4223440166 creator A5087363192 @default.
• W4223440166 creator A5089234882 @default.
• W4223440166 date "2022-04-08" @default.
• W4223440166 modified "2023-10-18" @default.
• W4223440166 title "Quantitative magnetic resonance imaging measures as biomarkers of disease progression in boys with Duchenne muscular dystrophy: a phase 2 trial of domagrozumab" @default.
• W4223440166 cites W1524530894 @default.
• W4223440166 cites W1922964466 @default.
• W4223440166 cites W1992147426 @default.
• W4223440166 cites W1996657560 @default.
• W4223440166 cites W2002936663 @default.
• W4223440166 cites W2005366749 @default.
• W4223440166 cites W2008993105 @default.
• W4223440166 cites W2018722071 @default.
• W4223440166 cites W2035041709 @default.
• W4223440166 cites W2050441916 @default.
• W4223440166 cites W2083700023 @default.
• W4223440166 cites W2135250056 @default.
• W4223440166 cites W2139702128 @default.
• W4223440166 cites W2142710825 @default.
• W4223440166 cites W2145803225 @default.
• W4223440166 cites W2234725241 @default.
• W4223440166 cites W2424490565 @default.
• W4223440166 cites W2530051463 @default.
• W4223440166 cites W2608444169 @default.
• W4223440166 cites W2753097429 @default.
• W4223440166 cites W2765458529 @default.
• W4223440166 cites W2767436720 @default.
• W4223440166 cites W2770733887 @default.
• W4223440166 cites W2784812244 @default.
• W4223440166 cites W2784992484 @default.
• W4223440166 cites W2907199792 @default.
• W4223440166 cites W2965599913 @default.
• W4223440166 cites W2998459048 @default.
• W4223440166 cites W3000540269 @default.
• W4223440166 cites W3005496462 @default.
• W4223440166 cites W3010225431 @default.
• W4223440166 cites W3028584612 @default.
• W4223440166 cites W3030480398 @default.
• W4223440166 cites W3119377901 @default.
• W4223440166 cites W3173927538 @default.
• W4223440166 doi "https://doi.org/10.1007/s00415-022-11084-0" @default.
• W4223440166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35396602" @default.
• W4223440166 hasPublicationYear "2022" @default.
• W4223440166 type Work @default.
• W4223440166 citedByCount "3" @default.
• W4223440166 countsByYear W42234401662022 @default.
• W4223440166 countsByYear W42234401662023 @default.
• W4223440166 crossrefType "journal-article" @default.
• W4223440166 hasAuthorship W4223440166A5002197436 @default.
• W4223440166 hasAuthorship W4223440166A5007427947 @default.
• W4223440166 hasAuthorship W4223440166A5012227405 @default.
• W4223440166 hasAuthorship W4223440166A5015956195 @default.
• W4223440166 hasAuthorship W4223440166A5020829434 @default.
• W4223440166 hasAuthorship W4223440166A5024414333 @default.
• W4223440166 hasAuthorship W4223440166A5040386348 @default.
• W4223440166 hasAuthorship W4223440166A5046308926 @default.
• W4223440166 hasAuthorship W4223440166A5062032887 @default.
• W4223440166 hasAuthorship W4223440166A5063362332 @default.
• W4223440166 hasAuthorship W4223440166A5071163954 @default.
• W4223440166 hasAuthorship W4223440166A5078152396 @default.
• W4223440166 hasAuthorship W4223440166A5081817483 @default.
• W4223440166 hasAuthorship W4223440166A5085970575 @default.
• W4223440166 hasAuthorship W4223440166A5087363192 @default.
• W4223440166 hasAuthorship W4223440166A5089234882 @default.
• W4223440166 hasBestOaLocation W42234401661 @default.
• W4223440166 hasConcept C126322002 @default.
• W4223440166 hasConcept C126838900 @default.
• W4223440166 hasConcept C143409427 @default.
• W4223440166 hasConcept C151730666 @default.
• W4223440166 hasConcept C164705383 @default.
• W4223440166 hasConcept C2778943923 @default.
• W4223440166 hasConcept C2779030066 @default.
• W4223440166 hasConcept C2779134260 @default.
• W4223440166 hasConcept C2779343474 @default.
• W4223440166 hasConcept C2779969927 @default.
• W4223440166 hasConcept C2780394045 @default.
• W4223440166 hasConcept C535046627 @default.
• W4223440166 hasConcept C71924100 @default.
• W4223440166 hasConcept C86803240 @default.
• W4223440166 hasConceptScore W4223440166C126322002 @default.
• W4223440166 hasConceptScore W4223440166C126838900 @default.
• W4223440166 hasConceptScore W4223440166C143409427 @default.

• next