Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223440169> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4223440169 endingPage "183" @default.
- W4223440169 startingPage "183" @default.
- W4223440169 abstract "Novel imidazo[2,1-b][1,3]thiazine derivatives modified with 4-pyridinyloxyl moiety, as potential anti-inflammatory agents are described. Synthetic approach to the preparation of (6-((pyridin-4-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazines 3a-f and their benzoanelated analogues 3g-j is based on the interaction of substituted 4-fluoropyridines with 3-hydroxy(benzo)imidazo[2,1-b][1,3]thiazines. The nucleophilic substitution reaction of the fluorine atom occurs selectively at position 4 of the pyridine ring. The drug-like properties of the first synthesized (4-pyridinyloxy)imidazo[2,1-b][1,3]thiazines were predicted in silico using SwissADME. Anti-inflammatory activity was studied in vivo using hind paw edema in white rats (carrageenan test). Compounds with satisfactory drug-like and pharmacological properties have been identified as promising for further structure optimization and in-depth research." @default.
- W4223440169 created "2022-04-14" @default.
- W4223440169 date "2022-04-02" @default.
- W4223440169 modified "2023-10-18" @default.
- W4223440169 title "Convenient Synthesis of 4-pyridinyloxy-Modified imidazo[2,1-b][1,3]thiazines as Potential Anti-inflammatory Agents" @default.
- W4223440169 doi "https://doi.org/10.33263/briac132.183" @default.
- W4223440169 hasPublicationYear "2022" @default.
- W4223440169 type Work @default.
- W4223440169 citedByCount "1" @default.
- W4223440169 countsByYear W42234401692022 @default.
- W4223440169 crossrefType "journal-article" @default.
- W4223440169 hasBestOaLocation W42234401691 @default.
- W4223440169 hasConcept C104317684 @default.
- W4223440169 hasConcept C150903083 @default.
- W4223440169 hasConcept C155647269 @default.
- W4223440169 hasConcept C178790620 @default.
- W4223440169 hasConcept C185592680 @default.
- W4223440169 hasConcept C207001950 @default.
- W4223440169 hasConcept C21951064 @default.
- W4223440169 hasConcept C2775905019 @default.
- W4223440169 hasConcept C2776568683 @default.
- W4223440169 hasConcept C2779485729 @default.
- W4223440169 hasConcept C2779703632 @default.
- W4223440169 hasConcept C2780378348 @default.
- W4223440169 hasConcept C2781186877 @default.
- W4223440169 hasConcept C2781227287 @default.
- W4223440169 hasConcept C55493867 @default.
- W4223440169 hasConcept C71240020 @default.
- W4223440169 hasConcept C71924100 @default.
- W4223440169 hasConcept C86803240 @default.
- W4223440169 hasConcept C98274493 @default.
- W4223440169 hasConceptScore W4223440169C104317684 @default.
- W4223440169 hasConceptScore W4223440169C150903083 @default.
- W4223440169 hasConceptScore W4223440169C155647269 @default.
- W4223440169 hasConceptScore W4223440169C178790620 @default.
- W4223440169 hasConceptScore W4223440169C185592680 @default.
- W4223440169 hasConceptScore W4223440169C207001950 @default.
- W4223440169 hasConceptScore W4223440169C21951064 @default.
- W4223440169 hasConceptScore W4223440169C2775905019 @default.
- W4223440169 hasConceptScore W4223440169C2776568683 @default.
- W4223440169 hasConceptScore W4223440169C2779485729 @default.
- W4223440169 hasConceptScore W4223440169C2779703632 @default.
- W4223440169 hasConceptScore W4223440169C2780378348 @default.
- W4223440169 hasConceptScore W4223440169C2781186877 @default.
- W4223440169 hasConceptScore W4223440169C2781227287 @default.
- W4223440169 hasConceptScore W4223440169C55493867 @default.
- W4223440169 hasConceptScore W4223440169C71240020 @default.
- W4223440169 hasConceptScore W4223440169C71924100 @default.
- W4223440169 hasConceptScore W4223440169C86803240 @default.
- W4223440169 hasConceptScore W4223440169C98274493 @default.
- W4223440169 hasIssue "2" @default.
- W4223440169 hasLocation W42234401691 @default.
- W4223440169 hasOpenAccess W4223440169 @default.
- W4223440169 hasPrimaryLocation W42234401691 @default.
- W4223440169 hasRelatedWork W2004533785 @default.
- W4223440169 hasRelatedWork W2035916807 @default.
- W4223440169 hasRelatedWork W2043308827 @default.
- W4223440169 hasRelatedWork W2177479229 @default.
- W4223440169 hasRelatedWork W2328656573 @default.
- W4223440169 hasRelatedWork W2414906195 @default.
- W4223440169 hasRelatedWork W4251152110 @default.
- W4223440169 hasRelatedWork W4286379142 @default.
- W4223440169 hasRelatedWork W4302008063 @default.
- W4223440169 hasRelatedWork W57999987 @default.
- W4223440169 hasVolume "13" @default.
- W4223440169 isParatext "false" @default.
- W4223440169 isRetracted "false" @default.
- W4223440169 workType "article" @default.