Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223443321> ?p ?o ?g. }
- W4223443321 endingPage "9" @default.
- W4223443321 startingPage "1" @default.
- W4223443321 abstract "The development of a functional organ requires not only patterning mechanisms that confer proper identities to individual cells, but also growth-regulatory mechanisms that specify the final size of the organ. At the turn of the 21st century, comprehensive genetic screens in model organisms had successfully uncovered the major signaling pathways that mediate pattern formation in metazoans. In contrast, signaling pathways dedicated to growth control were less explored. The past two decades has witnessed the emergence of the Hippo signaling pathway as a central mediator of organ size control through coordinated regulation of cell proliferation and apoptosis. Here I reflect on the early discoveries in Drosophila that elucidated the core kinase cascade and transcriptional machinery of the Hippo pathway, highlight its deep evolutionary conservation from humans to unicellular relatives of metazoan, and discuss the complex regulation of Hippo signaling by upstream inputs. This historical perspective underscores the importance of model organisms in uncovering fundamental and universal mechanisms of life processes." @default.
- W4223443321 created "2022-04-14" @default.
- W4223443321 creator A5087238383 @default.
- W4223443321 date "2022-07-01" @default.
- W4223443321 modified "2023-09-30" @default.
- W4223443321 title "The unfolding of the Hippo signaling pathway" @default.
- W4223443321 cites W1560352621 @default.
- W4223443321 cites W1606625034 @default.
- W4223443321 cites W1782202106 @default.
- W4223443321 cites W1884315263 @default.
- W4223443321 cites W1912766252 @default.
- W4223443321 cites W1921832013 @default.
- W4223443321 cites W1931360432 @default.
- W4223443321 cites W1963587413 @default.
- W4223443321 cites W1963927300 @default.
- W4223443321 cites W1966228205 @default.
- W4223443321 cites W1971556742 @default.
- W4223443321 cites W1971855104 @default.
- W4223443321 cites W1974037176 @default.
- W4223443321 cites W1976990850 @default.
- W4223443321 cites W1977832160 @default.
- W4223443321 cites W1978746441 @default.
- W4223443321 cites W1981831836 @default.
- W4223443321 cites W1983247384 @default.
- W4223443321 cites W1984488853 @default.
- W4223443321 cites W1984674883 @default.
- W4223443321 cites W1985046929 @default.
- W4223443321 cites W1993926535 @default.
- W4223443321 cites W2000572318 @default.
- W4223443321 cites W2002116477 @default.
- W4223443321 cites W2006932987 @default.
- W4223443321 cites W2007455356 @default.
- W4223443321 cites W2012674191 @default.
- W4223443321 cites W2020495210 @default.
- W4223443321 cites W2023267153 @default.
- W4223443321 cites W2023471348 @default.
- W4223443321 cites W2023819606 @default.
- W4223443321 cites W2025851393 @default.
- W4223443321 cites W2028274324 @default.
- W4223443321 cites W2029879339 @default.
- W4223443321 cites W2029976610 @default.
- W4223443321 cites W2031795488 @default.
- W4223443321 cites W2032685334 @default.
- W4223443321 cites W2033440293 @default.
- W4223443321 cites W2034071612 @default.
- W4223443321 cites W2034820114 @default.
- W4223443321 cites W2043092063 @default.
- W4223443321 cites W2055378633 @default.
- W4223443321 cites W2056182849 @default.
- W4223443321 cites W2060020667 @default.
- W4223443321 cites W2065978566 @default.
- W4223443321 cites W2066505201 @default.
- W4223443321 cites W2067458366 @default.
- W4223443321 cites W2067592231 @default.
- W4223443321 cites W2070107376 @default.
- W4223443321 cites W2070879574 @default.
- W4223443321 cites W2073568903 @default.
- W4223443321 cites W2073793307 @default.
- W4223443321 cites W2074584250 @default.
- W4223443321 cites W2076247671 @default.
- W4223443321 cites W2078027095 @default.
- W4223443321 cites W2081526354 @default.
- W4223443321 cites W2083106714 @default.
- W4223443321 cites W2085197940 @default.
- W4223443321 cites W2085250524 @default.
- W4223443321 cites W2088526239 @default.
- W4223443321 cites W2091427349 @default.
- W4223443321 cites W2092128105 @default.
- W4223443321 cites W2093021491 @default.
- W4223443321 cites W2094562654 @default.
- W4223443321 cites W2099072529 @default.
- W4223443321 cites W2099105062 @default.
- W4223443321 cites W2099709490 @default.
- W4223443321 cites W2100641053 @default.
- W4223443321 cites W2101538557 @default.
- W4223443321 cites W2103304405 @default.
- W4223443321 cites W2106029142 @default.
- W4223443321 cites W2117841435 @default.
- W4223443321 cites W2118671972 @default.
- W4223443321 cites W2120546609 @default.
- W4223443321 cites W2124813584 @default.
- W4223443321 cites W2127538704 @default.
- W4223443321 cites W2133567026 @default.
- W4223443321 cites W2133616332 @default.
- W4223443321 cites W2141595533 @default.
- W4223443321 cites W2141652419 @default.
- W4223443321 cites W2146321861 @default.
- W4223443321 cites W2146337514 @default.
- W4223443321 cites W2147926680 @default.
- W4223443321 cites W2148056172 @default.
- W4223443321 cites W2159935247 @default.
- W4223443321 cites W2163167640 @default.
- W4223443321 cites W2163219259 @default.
- W4223443321 cites W2168621651 @default.
- W4223443321 cites W2225462341 @default.
- W4223443321 cites W2266822253 @default.
- W4223443321 cites W2510865896 @default.
- W4223443321 cites W2512544075 @default.