Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223446545> ?p ?o ?g. }
- W4223446545 endingPage "1873" @default.
- W4223446545 startingPage "1862" @default.
- W4223446545 abstract "Clostridioides difficile bacteria can cause life-threatening diarrhea and colitis owing to limited treatment options and unacceptably high recurrence rates among infected patients. This necessitates the development of alternative routes for C. difficile treatment. Drug repurposing with new indications represents a proven shortcut. Here, we present a refined focus on 16 FDA-approved drugs that would be suitable for further development as potential anti-C. difficile drugs. Of these drugs, clinical trials have been conducted on five currently used drugs; however, ursodeoxycholic acid is the only drug to enter Phase IV clinical trials to date. Thus, drug repurposing promotes the study of mechanistic and therapeutic strategies, providing new options for the development of next-generation anti-C. difficile agents." @default.
- W4223446545 created "2022-04-14" @default.
- W4223446545 creator A5028588336 @default.
- W4223446545 creator A5033020983 @default.
- W4223446545 creator A5064317694 @default.
- W4223446545 creator A5069962114 @default.
- W4223446545 creator A5083847520 @default.
- W4223446545 creator A5086186709 @default.
- W4223446545 creator A5087912416 @default.
- W4223446545 date "2022-07-01" @default.
- W4223446545 modified "2023-10-16" @default.
- W4223446545 title "Targeting Clostridioides difficile: New uses for old drugs." @default.
- W4223446545 cites W1479918971 @default.
- W4223446545 cites W1796131488 @default.
- W4223446545 cites W1974115528 @default.
- W4223446545 cites W1989761771 @default.
- W4223446545 cites W1991342067 @default.
- W4223446545 cites W1994668407 @default.
- W4223446545 cites W2000721637 @default.
- W4223446545 cites W2029152115 @default.
- W4223446545 cites W2041051832 @default.
- W4223446545 cites W2043587412 @default.
- W4223446545 cites W2045417011 @default.
- W4223446545 cites W2047204678 @default.
- W4223446545 cites W2068351024 @default.
- W4223446545 cites W2076279677 @default.
- W4223446545 cites W2083616386 @default.
- W4223446545 cites W2085442390 @default.
- W4223446545 cites W2086572650 @default.
- W4223446545 cites W2092416470 @default.
- W4223446545 cites W2093005831 @default.
- W4223446545 cites W2093313266 @default.
- W4223446545 cites W2098666011 @default.
- W4223446545 cites W2104370565 @default.
- W4223446545 cites W2113335688 @default.
- W4223446545 cites W2122892287 @default.
- W4223446545 cites W2125159822 @default.
- W4223446545 cites W2128037129 @default.
- W4223446545 cites W2129379280 @default.
- W4223446545 cites W2129718760 @default.
- W4223446545 cites W2131038214 @default.
- W4223446545 cites W2144282350 @default.
- W4223446545 cites W2148881504 @default.
- W4223446545 cites W2158788819 @default.
- W4223446545 cites W2159005358 @default.
- W4223446545 cites W2165003341 @default.
- W4223446545 cites W2202785594 @default.
- W4223446545 cites W2268645719 @default.
- W4223446545 cites W2327520448 @default.
- W4223446545 cites W2336025071 @default.
- W4223446545 cites W2342340404 @default.
- W4223446545 cites W2444690946 @default.
- W4223446545 cites W2509510848 @default.
- W4223446545 cites W2520472295 @default.
- W4223446545 cites W2566975142 @default.
- W4223446545 cites W2582069104 @default.
- W4223446545 cites W2731562837 @default.
- W4223446545 cites W2766759933 @default.
- W4223446545 cites W2791326569 @default.
- W4223446545 cites W2794263799 @default.
- W4223446545 cites W2806662900 @default.
- W4223446545 cites W2806824088 @default.
- W4223446545 cites W2808081722 @default.
- W4223446545 cites W2884680379 @default.
- W4223446545 cites W2887568085 @default.
- W4223446545 cites W2893179729 @default.
- W4223446545 cites W2906672401 @default.
- W4223446545 cites W2913305156 @default.
- W4223446545 cites W2947090615 @default.
- W4223446545 cites W2948127891 @default.
- W4223446545 cites W2952252976 @default.
- W4223446545 cites W2964302983 @default.
- W4223446545 cites W2964643846 @default.
- W4223446545 cites W2967091266 @default.
- W4223446545 cites W3012029590 @default.
- W4223446545 cites W3012851537 @default.
- W4223446545 cites W3014161470 @default.
- W4223446545 cites W3015169388 @default.
- W4223446545 cites W3021386779 @default.
- W4223446545 cites W3021915523 @default.
- W4223446545 cites W3035031070 @default.
- W4223446545 cites W3039953554 @default.
- W4223446545 cites W3091999949 @default.
- W4223446545 doi "https://doi.org/10.1016/j.drudis.2022.03.021" @default.
- W4223446545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35390545" @default.
- W4223446545 hasPublicationYear "2022" @default.
- W4223446545 type Work @default.
- W4223446545 citedByCount "5" @default.
- W4223446545 countsByYear W42234465452022 @default.
- W4223446545 countsByYear W42234465452023 @default.
- W4223446545 crossrefType "journal-article" @default.
- W4223446545 hasAuthorship W4223446545A5028588336 @default.
- W4223446545 hasAuthorship W4223446545A5033020983 @default.
- W4223446545 hasAuthorship W4223446545A5064317694 @default.
- W4223446545 hasAuthorship W4223446545A5069962114 @default.
- W4223446545 hasAuthorship W4223446545A5083847520 @default.
- W4223446545 hasAuthorship W4223446545A5086186709 @default.
- W4223446545 hasAuthorship W4223446545A5087912416 @default.