FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223447321> ?p ?o ?g. }

• W4223447321 abstract "Ubiquitylation is critical for preventing aberrant DNA repair and for efficient maintenance of genome stability. As deubiquitylases (DUBs) counteract ubiquitylation, they must have a great influence on many biological processes, including DNA damage response. To elucidate the role of DUBs in DNA repair in Drosophila melanogaster, systematic siRNA screening was applied to identify DUBs with a reduced survival rate following exposure to ultraviolet and X-ray radiations. As a secondary validation, we applied the direct repeat (DR)-white reporter system with which we induced site-specific DSBs and affirmed the importance of the DUBs Ovarian tumor domain-containing deubiquitinating enzyme 1 (Otu1), Ubiquitin carboxyl-terminal hydrolase 5 (Usp5), and Ubiquitin carboxyl-terminal hydrolase 34 (Usp34) in DSB repair pathways using Drosophila. Our results indicate that the loss of Otu1 and Usp5 induces strong position effect variegation in Drosophila eye following I-SceI-induced DSB deployment. Otu1 and Usp5 are essential in DNA damage-induced cellular response, and both DUBs are required for the fine-tuned regulation of the non-homologous end joining pathway. Furthermore, the Drosophila DR-white assay demonstrated that homologous recombination does not occur in the absence of Usp34, indicating an indispensable role of Usp34 in this process." @default.
• W4223447321 created "2022-04-14" @default.
• W4223447321 creator A5017981048 @default.
• W4223447321 creator A5032129414 @default.
• W4223447321 creator A5035342714 @default.
• W4223447321 creator A5055488203 @default.
• W4223447321 creator A5064933071 @default.
• W4223447321 creator A5071286258 @default.
• W4223447321 date "2022-04-07" @default.
• W4223447321 modified "2023-10-17" @default.
• W4223447321 title "Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster" @default.
• W4223447321 cites W1482236046 @default.
• W4223447321 cites W1864085864 @default.
• W4223447321 cites W1907342860 @default.
• W4223447321 cites W1974115460 @default.
• W4223447321 cites W1987211450 @default.
• W4223447321 cites W1990963600 @default.
• W4223447321 cites W1991539695 @default.
• W4223447321 cites W2000017794 @default.
• W4223447321 cites W2006089315 @default.
• W4223447321 cites W2012081711 @default.
• W4223447321 cites W2021565943 @default.
• W4223447321 cites W2045979076 @default.
• W4223447321 cites W2047801109 @default.
• W4223447321 cites W2054666944 @default.
• W4223447321 cites W2056419964 @default.
• W4223447321 cites W2072155586 @default.
• W4223447321 cites W2083903439 @default.
• W4223447321 cites W2087437632 @default.
• W4223447321 cites W2088724822 @default.
• W4223447321 cites W2095424116 @default.
• W4223447321 cites W2106571916 @default.
• W4223447321 cites W2114982790 @default.
• W4223447321 cites W2133819225 @default.
• W4223447321 cites W2145200068 @default.
• W4223447321 cites W2145780127 @default.
• W4223447321 cites W2186183680 @default.
• W4223447321 cites W2219799225 @default.
• W4223447321 cites W2281048538 @default.
• W4223447321 cites W2285209545 @default.
• W4223447321 cites W2309129328 @default.
• W4223447321 cites W2479329624 @default.
• W4223447321 cites W2592860328 @default.
• W4223447321 cites W2865431834 @default.
• W4223447321 cites W2895902705 @default.
• W4223447321 cites W2946681623 @default.
• W4223447321 cites W2999765691 @default.
• W4223447321 cites W3035145149 @default.
• W4223447321 cites W3036589062 @default.
• W4223447321 doi "https://doi.org/10.1038/s41598-022-09703-x" @default.
• W4223447321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35393473" @default.
• W4223447321 hasPublicationYear "2022" @default.
• W4223447321 type Work @default.
• W4223447321 citedByCount "1" @default.
• W4223447321 countsByYear W42234473212023 @default.
• W4223447321 crossrefType "journal-article" @default.
• W4223447321 hasAuthorship W4223447321A5017981048 @default.
• W4223447321 hasAuthorship W4223447321A5032129414 @default.
• W4223447321 hasAuthorship W4223447321A5035342714 @default.
• W4223447321 hasAuthorship W4223447321A5055488203 @default.
• W4223447321 hasAuthorship W4223447321A5064933071 @default.
• W4223447321 hasAuthorship W4223447321A5071286258 @default.
• W4223447321 hasBestOaLocation W42234473211 @default.
• W4223447321 hasConcept C102658986 @default.
• W4223447321 hasConcept C102744134 @default.
• W4223447321 hasConcept C104317684 @default.
• W4223447321 hasConcept C134935766 @default.
• W4223447321 hasConcept C136961756 @default.
• W4223447321 hasConcept C143425029 @default.
• W4223447321 hasConcept C166703698 @default.
• W4223447321 hasConcept C25602115 @default.
• W4223447321 hasConcept C2780104201 @default.
• W4223447321 hasConcept C54355233 @default.
• W4223447321 hasConcept C552990157 @default.
• W4223447321 hasConcept C67705224 @default.
• W4223447321 hasConcept C86803240 @default.
• W4223447321 hasConcept C95444343 @default.
• W4223447321 hasConceptScore W4223447321C102658986 @default.
• W4223447321 hasConceptScore W4223447321C102744134 @default.
• W4223447321 hasConceptScore W4223447321C104317684 @default.
• W4223447321 hasConceptScore W4223447321C134935766 @default.
• W4223447321 hasConceptScore W4223447321C136961756 @default.
• W4223447321 hasConceptScore W4223447321C143425029 @default.
• W4223447321 hasConceptScore W4223447321C166703698 @default.
• W4223447321 hasConceptScore W4223447321C25602115 @default.
• W4223447321 hasConceptScore W4223447321C2780104201 @default.
• W4223447321 hasConceptScore W4223447321C54355233 @default.
• W4223447321 hasConceptScore W4223447321C552990157 @default.
• W4223447321 hasConceptScore W4223447321C67705224 @default.
• W4223447321 hasConceptScore W4223447321C86803240 @default.
• W4223447321 hasConceptScore W4223447321C95444343 @default.
• W4223447321 hasFunder F4320329149 @default.
• W4223447321 hasIssue "1" @default.
• W4223447321 hasLocation W42234473211 @default.
• W4223447321 hasLocation W42234473212 @default.
• W4223447321 hasLocation W42234473213 @default.
• W4223447321 hasLocation W42234473214 @default.
• W4223447321 hasLocation W42234473215 @default.
• W4223447321 hasLocation W42234473216 @default.
• W4223447321 hasOpenAccess W4223447321 @default.

• next