FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223447454> ?p ?o ?g. }

• W4223447454 endingPage "1359" @default.
• W4223447454 startingPage "1351" @default.
• W4223447454 abstract "Are there genetic variants that interact with smoking to reduce reproductive lifespan in East-Asian women?Our study corroborates several recently identified genetic loci associated with reproductive lifespan and highlights specific genetic predispositions that may interact with smoking status to adversely affect reproductive lifespan in East-Asian women.Epidemiological data as well as evaluations on genetic predisposition to smoke indicate on the importance of smoking in adverse effects on reproductive lifespan in women. However, there are no previous smoking and gene interaction studies for reproductive traits in East-Asian women.This population-based prospective cohort study comprised 11 643 East-Asian Chinese women with overlapping genome-wide genotyping and reproductive data.We performed a genome-wide association study for reproductive lifespan in women (n = 11 643) from the Singapore Chinese Health Study (SCHS) and carried out a genome-wide interaction study to identify loci that interacted with smoking status to affect age of natural menopause and reproductive-time.Two known loci associated with menopause, rs113430717 (near HMCES, chromosome 3, Pmeta = 5.72 × 10-15) and rs3020136 (near RAD21, chromosome 8, Pmeta = 1.38 × 10-8) were observed beyond genome-wide levels of association with age at menopause in this study. For reproductive lifespan, the genome-wide association observed at rs79784106 (chromosome 3, Pmeta = 5.05 × 10-12) was in linkage disequilibrium with the menopause lead single-nucleotide polymorphism (SNP) (rs113430717). Four additional loci, first reported to be associated with menopause, were also associated with reproductive lifespan in our study (PAdj between 7.42 × 10-5 to 4.51 × 10-3). A significant interaction was observed between smoking and an East-Asian specific SNP, rs140146885, for reduced reproductive lifespan, per copy of the minor C allele (beta = -1.417 years, Pinteraction = 2.31 × 10-10). This interaction was successfully replicated in additional independent samples (beta = -1.389 years, Pinteraction = 6.78 × 10-3). Another known variant associated with menopause, rs11031006 (near FSHB), was also observed to interact with smoking status to reduce age at menopause in our dataset (beta = -0.450 years, Padj = 0.042).The modest sample size of the replication datasets used likely affected the statistical power to firmly replicate all identified novel loci observed in our smoking interaction analyses.Age of natural menopause and reproductive lifespan have clear genetic predispositions with distinct ethnic differences, and they may be adversely truncated by lifestyle factors such as smoking, which can pose a significant impact on the reproductive lifespan and future health outcomes in women.The Singapore Chinese Health Study is funded by the National Medical Research Council, Singapore (NMRC/CIRG/1456/2016), National Institutes of Health (R01 CA144034 and UM1 CA182876) and National Research Foundation, Singapore (Project Number 370062002). W.-P.K. is supported by the National Medical Research Council, Singapore (MOH-CSASI19nov-0001). The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The authors do not report conflicts of interest.N/A." @default.
• W4223447454 created "2022-04-14" @default.
• W4223447454 creator A5019713852 @default.
• W4223447454 creator A5023467865 @default.
• W4223447454 creator A5035282947 @default.
• W4223447454 creator A5050487837 @default.
• W4223447454 creator A5054773456 @default.
• W4223447454 creator A5068182723 @default.
• W4223447454 creator A5080847227 @default.
• W4223447454 creator A5081606775 @default.
• W4223447454 creator A5087877589 @default.
• W4223447454 date "2022-04-12" @default.
• W4223447454 modified "2023-10-15" @default.
• W4223447454 title "Interaction between cigarette smoking and genetic polymorphisms on the associations with age of natural menopause and reproductive lifespan: the Singapore Chinese Health Study" @default.
• W4223447454 cites W1981809281 @default.
• W4223447454 cites W1990415003 @default.
• W4223447454 cites W1995951269 @default.
• W4223447454 cites W1996986163 @default.
• W4223447454 cites W2025057538 @default.
• W4223447454 cites W2053105417 @default.
• W4223447454 cites W2057557536 @default.
• W4223447454 cites W2058076589 @default.
• W4223447454 cites W2076396506 @default.
• W4223447454 cites W2105550885 @default.
• W4223447454 cites W2111985781 @default.
• W4223447454 cites W2119586206 @default.
• W4223447454 cites W2120900300 @default.
• W4223447454 cites W2142813137 @default.
• W4223447454 cites W2149791927 @default.
• W4223447454 cites W2161656900 @default.
• W4223447454 cites W2271112859 @default.
• W4223447454 cites W2408861655 @default.
• W4223447454 cites W2466672331 @default.
• W4223447454 cites W2474741641 @default.
• W4223447454 cites W2489838582 @default.
• W4223447454 cites W2491158000 @default.
• W4223447454 cites W2555860667 @default.
• W4223447454 cites W2608920382 @default.
• W4223447454 cites W2717890002 @default.
• W4223447454 cites W2770092353 @default.
• W4223447454 cites W2783428649 @default.
• W4223447454 cites W2895323672 @default.
• W4223447454 cites W2902650905 @default.
• W4223447454 cites W2903238503 @default.
• W4223447454 cites W2937482092 @default.
• W4223447454 cites W2952671741 @default.
• W4223447454 cites W3006817522 @default.
• W4223447454 cites W3016804241 @default.
• W4223447454 cites W3043524938 @default.
• W4223447454 cites W3088349536 @default.
• W4223447454 cites W3092016344 @default.
• W4223447454 cites W3133687914 @default.
• W4223447454 cites W3144317833 @default.
• W4223447454 cites W3152739244 @default.
• W4223447454 cites W3159894416 @default.
• W4223447454 cites W3185710912 @default.
• W4223447454 cites W4211122966 @default.
• W4223447454 doi "https://doi.org/10.1093/humrep/deac075" @default.
• W4223447454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35413122" @default.
• W4223447454 hasPublicationYear "2022" @default.
• W4223447454 type Work @default.
• W4223447454 citedByCount "3" @default.
• W4223447454 countsByYear W42234474542023 @default.
• W4223447454 crossrefType "journal-article" @default.
• W4223447454 hasAuthorship W4223447454A5019713852 @default.
• W4223447454 hasAuthorship W4223447454A5023467865 @default.
• W4223447454 hasAuthorship W4223447454A5035282947 @default.
• W4223447454 hasAuthorship W4223447454A5050487837 @default.
• W4223447454 hasAuthorship W4223447454A5054773456 @default.
• W4223447454 hasAuthorship W4223447454A5068182723 @default.
• W4223447454 hasAuthorship W4223447454A5080847227 @default.
• W4223447454 hasAuthorship W4223447454A5081606775 @default.
• W4223447454 hasAuthorship W4223447454A5087877589 @default.
• W4223447454 hasBestOaLocation W42234474542 @default.
• W4223447454 hasConcept C104317684 @default.
• W4223447454 hasConcept C106208931 @default.
• W4223447454 hasConcept C135763542 @default.
• W4223447454 hasConcept C153209595 @default.
• W4223447454 hasConcept C2908647359 @default.
• W4223447454 hasConcept C35605836 @default.
• W4223447454 hasConcept C54355233 @default.
• W4223447454 hasConcept C71924100 @default.
• W4223447454 hasConcept C86803240 @default.
• W4223447454 hasConcept C99454951 @default.
• W4223447454 hasConceptScore W4223447454C104317684 @default.
• W4223447454 hasConceptScore W4223447454C106208931 @default.
• W4223447454 hasConceptScore W4223447454C135763542 @default.
• W4223447454 hasConceptScore W4223447454C153209595 @default.
• W4223447454 hasConceptScore W4223447454C2908647359 @default.
• W4223447454 hasConceptScore W4223447454C35605836 @default.
• W4223447454 hasConceptScore W4223447454C54355233 @default.
• W4223447454 hasConceptScore W4223447454C71924100 @default.
• W4223447454 hasConceptScore W4223447454C86803240 @default.
• W4223447454 hasConceptScore W4223447454C99454951 @default.
• W4223447454 hasFunder F4320320671 @default.
• W4223447454 hasFunder F4320332161 @default.
• W4223447454 hasFunder F4320334737 @default.
• W4223447454 hasIssue "6" @default.

• next