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- W4223448639 abstract "To characterize diabetic retinopathy (DR) progression without therapy.This post hoc analysis of the phase 3 RIDE and RISE trials examined the association between baseline DR severity on rates of ≥ 2-step DR progression and improvement in untreated fellow eyes (n = 530) and ranibizumab-treated study eyes (n = 369). Kaplan-Meier analyses estimated progression to proliferative DR (PDR) over 2 years in eyes with nonproliferative DR (NPDR) at baseline.At month 24, 28.8% of untreated fellow eyes with moderately severe to severe NPDR at baseline experienced ≥ 2-step DR progression, versus 10.3% of eyes with absent to moderate NPDR and 0 eyes with mild- to high-risk proliferative DR. Of the untreated fellow eyes with moderately severe to severe NPDR, 18.9% achieved ≥ 2-step DR improvement, compared with 88.4% of ranibizumab-treated eyes.Without treatment, patients with moderately severe to severe NPDR are at risk of rapid disease progression and vision loss. [Ophthalmic Surg Lasers Imaging Retina. 2022;53(4):202-207.]." @default.
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- W4223448639 date "2022-04-01" @default.
- W4223448639 modified "2023-09-30" @default.
- W4223448639 title "Course of Diabetic Retinopathy in Untreated Fellow Eyes in RIDE and RISE: A Post Hoc Analysis" @default.
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- W4223448639 doi "https://doi.org/10.3928/23258160-20220311-03" @default.
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