Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223457584> ?p ?o ?g. }
- W4223457584 endingPage "103086" @default.
- W4223457584 startingPage "103086" @default.
- W4223457584 abstract "Antinuclear antibodies (ANA) detected in juvenile idiopathic arthritis (JIA) sera are considered to be a biomarker for JIA-related uveitis. There is an unclear consensus on the screening dilutions of ANA as detected by the HEp-2 indirect immunofluorescence assay (IFA) that should be used when predicting the risk of uveitis in JIA. The primary aim of this systematic review and meta-analysis was to summarize the evidence regarding ANA prevalence and performance in JIA and JIA-associated uveitis.A search of five databases identified 1766 abstracts, using the search terms juvenile idiopathic arthritis; pediatric; sensitivity or diagnostic; and ANA. Studies that met inclusion/exclusion criteria were analyzed for the proportion of JIA patients with a positive ANA. Forest plots and pooled estimates were generated for the proportion of JIA patients and those with uveitis who were positive for ANA stratified by screening dilution. Study heterogeneity was also assessed.Twenty-eight studies met inclusion criteria yielding 6250 unique patients; 5902 had JIA and 348 were healthy controls or were known to have other autoimmune diseases. The most reported IFA serum screening dilution was ≥1:80, representing 41.9% of patients and this screening dilution had the highest proportion of JIA ANA positivity (41.0%; 95% CI 25.0%-57.0%). ANA screening for JIA uveitis had a sensitivity and specificity of ANA at ≥1:40 of 75% (95% CI 46%-100%) and 66% (95% CI 39%-93%), respectively. There was significant study heterogeneity across both JIA subtypes and ANA titres.Although there was a large variation of ANA IFA screening dilutions used for investigation of JIA, the most common dilution was 1:80. The current literature has several important deficiencies that are identified in this review requiring additional studies to inform the ANA screening dilutions of clinical value in JIA and JIA-associated uveitis." @default.
- W4223457584 created "2022-04-15" @default.
- W4223457584 creator A5011458972 @default.
- W4223457584 creator A5024087983 @default.
- W4223457584 creator A5025272315 @default.
- W4223457584 creator A5035984700 @default.
- W4223457584 creator A5042979209 @default.
- W4223457584 creator A5074916921 @default.
- W4223457584 creator A5081769343 @default.
- W4223457584 creator A5091396579 @default.
- W4223457584 date "2022-06-01" @default.
- W4223457584 modified "2023-10-16" @default.
- W4223457584 title "Prevalence and titres of antinuclear antibodies in juvenile idiopathic arthritis: A systematic review and meta-analysis" @default.
- W4223457584 cites W1542331779 @default.
- W4223457584 cites W1773465775 @default.
- W4223457584 cites W1971437489 @default.
- W4223457584 cites W1972835857 @default.
- W4223457584 cites W1986412121 @default.
- W4223457584 cites W1999506970 @default.
- W4223457584 cites W2007784090 @default.
- W4223457584 cites W2020899229 @default.
- W4223457584 cites W2026320588 @default.
- W4223457584 cites W2034837040 @default.
- W4223457584 cites W2036644487 @default.
- W4223457584 cites W2042459139 @default.
- W4223457584 cites W2075591761 @default.
- W4223457584 cites W2124535709 @default.
- W4223457584 cites W2125497658 @default.
- W4223457584 cites W2130650826 @default.
- W4223457584 cites W2143238849 @default.
- W4223457584 cites W2155620498 @default.
- W4223457584 cites W2168908756 @default.
- W4223457584 cites W2579468829 @default.
- W4223457584 cites W2749108377 @default.
- W4223457584 cites W2789785220 @default.
- W4223457584 cites W2801821517 @default.
- W4223457584 cites W2900672344 @default.
- W4223457584 cites W2921652873 @default.
- W4223457584 cites W2969934144 @default.
- W4223457584 cites W2970149320 @default.
- W4223457584 cites W2972378859 @default.
- W4223457584 cites W3011609055 @default.
- W4223457584 cites W3015278681 @default.
- W4223457584 cites W3096034674 @default.
- W4223457584 cites W3111569995 @default.
- W4223457584 cites W3152392295 @default.
- W4223457584 cites W3195053142 @default.
- W4223457584 cites W3204330487 @default.
- W4223457584 cites W4205869877 @default.
- W4223457584 cites W4206139296 @default.
- W4223457584 cites W4248595528 @default.
- W4223457584 cites W4254553165 @default.
- W4223457584 doi "https://doi.org/10.1016/j.autrev.2022.103086" @default.
- W4223457584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35398272" @default.
- W4223457584 hasPublicationYear "2022" @default.
- W4223457584 type Work @default.
- W4223457584 citedByCount "7" @default.
- W4223457584 countsByYear W42234575842022 @default.
- W4223457584 countsByYear W42234575842023 @default.
- W4223457584 crossrefType "journal-article" @default.
- W4223457584 hasAuthorship W4223457584A5011458972 @default.
- W4223457584 hasAuthorship W4223457584A5024087983 @default.
- W4223457584 hasAuthorship W4223457584A5025272315 @default.
- W4223457584 hasAuthorship W4223457584A5035984700 @default.
- W4223457584 hasAuthorship W4223457584A5042979209 @default.
- W4223457584 hasAuthorship W4223457584A5074916921 @default.
- W4223457584 hasAuthorship W4223457584A5081769343 @default.
- W4223457584 hasAuthorship W4223457584A5091396579 @default.
- W4223457584 hasBestOaLocation W42234575841 @default.
- W4223457584 hasConcept C126322002 @default.
- W4223457584 hasConcept C142724271 @default.
- W4223457584 hasConcept C149443304 @default.
- W4223457584 hasConcept C159654299 @default.
- W4223457584 hasConcept C163764329 @default.
- W4223457584 hasConcept C203014093 @default.
- W4223457584 hasConcept C204787440 @default.
- W4223457584 hasConcept C2776194053 @default.
- W4223457584 hasConcept C2777077863 @default.
- W4223457584 hasConcept C2777596629 @default.
- W4223457584 hasConcept C2984894117 @default.
- W4223457584 hasConcept C71924100 @default.
- W4223457584 hasConcept C95190672 @default.
- W4223457584 hasConceptScore W4223457584C126322002 @default.
- W4223457584 hasConceptScore W4223457584C142724271 @default.
- W4223457584 hasConceptScore W4223457584C149443304 @default.
- W4223457584 hasConceptScore W4223457584C159654299 @default.
- W4223457584 hasConceptScore W4223457584C163764329 @default.
- W4223457584 hasConceptScore W4223457584C203014093 @default.
- W4223457584 hasConceptScore W4223457584C204787440 @default.
- W4223457584 hasConceptScore W4223457584C2776194053 @default.
- W4223457584 hasConceptScore W4223457584C2777077863 @default.
- W4223457584 hasConceptScore W4223457584C2777596629 @default.
- W4223457584 hasConceptScore W4223457584C2984894117 @default.
- W4223457584 hasConceptScore W4223457584C71924100 @default.
- W4223457584 hasConceptScore W4223457584C95190672 @default.
- W4223457584 hasIssue "6" @default.
- W4223457584 hasLocation W42234575841 @default.
- W4223457584 hasLocation W42234575842 @default.