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- W4223461719 abstract "The tissue-specific drivers of neurosarcoidosis remain poorly defined. To identify cerebrospinal fluid (CSF) specific, antigen-driven T and B cell responses, we performed single-cell RNA sequencing of CSF and blood cells from neurosarcoid participants coupled to T and B cell receptor sequencing. In contrast to pulmonary sarcoidosis, which is driven by CD4 T cells, we found CD8 T cell clonal expansion enriched in the neurosarcoid CSF. These CSF-enriched CD8 T cells were composed of two subsets with differential expression of EBI2, CXCR3, and CXCR4. Lastly, our data suggest that IFNγ signaling may distinguish neurosarcoidosis from other neurological disorders." @default.
- W4223461719 created "2022-04-15" @default.
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- W4223461719 date "2022-06-01" @default.
- W4223461719 modified "2023-10-03" @default.
- W4223461719 title "The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells" @default.
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- W4223461719 doi "https://doi.org/10.1016/j.jneuroim.2022.577860" @default.
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