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- W4223463975 abstract "Abstract Purpose The aim of our study was to investigate spontaneous resolution and postnatal outcome in non-immune hydrops fetalis (NIHF). We specifically studied NIHF cases that occurred without any other anomalies in the prenatal diagnostic workup, defined as isolated NIHF (iNIHF). Methods To identify iNIHF we retrospectively classified prenatal findings of 703 NIHF singletons, diagnosed in our prenatal referral center between 1997 and 2016. We studied the occurrence of prenatal resolution in iNIHF and linked it to the perinatal outcome. We obtained long-term outcome by contacting the parents, children, and the pediatricians and listed all functional and structural anomalies and temporary logopedic, psychosocial and motoric impairments. Results Among 73 iNIHF cases, 57 (78.1%) resolved completely prenatally. The baby-take-home rate was 98.2% in these cases. In contrast, the baby-take-home rate in the subgroup without complete resolution was 25.0%. We achieved pediatric long-term outcome in 28 of 60 survivors (46.6%) of iNIHF with a mean follow-up period of 10.4 years. Among these 28 children, fetal hydrops had completely resolved prenatally in 27 cases and had regressed to a mild effusion in one case. In the pediatric development, two children had significant functional impairment and three children showed recurrent skin edema. Conclusion Complete spontaneous resolution was the most common intrauterine course of iNIHF in our collective. Completely resolved iNIHF had a favorable perinatal outcome in our study. Our data on the long-term outcomes are consistent with the assumption of an increased rate of functional impairments. TRIAL REGSTRATION NUMBER Internal study number of Heinrich-Heine-University, Duesseldorf: 6177RDate of registration: December 2017" @default.
- W4223463975 created "2022-04-15" @default.
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- W4223463975 date "2022-04-11" @default.
- W4223463975 modified "2023-10-16" @default.
- W4223463975 title "Isolated non-immune hydrops fetalis: an observational study on complete spontaneous resolution, perinatal outcome, and long-term follow-up" @default.
- W4223463975 doi "https://doi.org/10.21203/rs.3.rs-1518981/v1" @default.
- W4223463975 hasPublicationYear "2022" @default.
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