Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223470904> ?p ?o ?g. }
- W4223470904 abstract "Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established RNA-binding complex, the biological function of PRC2-RNA interaction has been controversial. Here, we study the gene-regulatory role of the inhibitory PRC2-RNA interactions. We report a nuclear long non-coding RNA, LEVER, which mapped 236 kb upstream of the β-globin cluster as confirmed by Nanopore sequencing. LEVER RNA interacts with PRC2 in its nascent form, and this prevents the accumulation of the H3K27 repressive histone marks within LEVER locus. Interestingly, the accessible LEVER chromatin, in turn, suppresses the chromatin interactions between the ε-globin locus and β-globin locus control region (LCR), resulting in a repressive effect on ε-globin gene expression. Our findings validate that the nascent RNA-PRC2 interaction inhibits local PRC2 function in situ. More importantly, we demonstrate that such a local process can in turn regulate the expression of neighboring genes." @default.
- W4223470904 created "2022-04-15" @default.
- W4223470904 creator A5002970730 @default.
- W4223470904 creator A5008473414 @default.
- W4223470904 creator A5015800351 @default.
- W4223470904 creator A5033724435 @default.
- W4223470904 creator A5044887449 @default.
- W4223470904 creator A5052960352 @default.
- W4223470904 creator A5053761367 @default.
- W4223470904 creator A5054735033 @default.
- W4223470904 creator A5057138426 @default.
- W4223470904 creator A5058977705 @default.
- W4223470904 creator A5062891826 @default.
- W4223470904 creator A5065813780 @default.
- W4223470904 date "2022-04-11" @default.
- W4223470904 modified "2023-09-30" @default.
- W4223470904 title "Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation" @default.
- W4223470904 cites W1540381414 @default.
- W4223470904 cites W1592870802 @default.
- W4223470904 cites W1739743960 @default.
- W4223470904 cites W1971313898 @default.
- W4223470904 cites W1977943782 @default.
- W4223470904 cites W1984023556 @default.
- W4223470904 cites W1987592711 @default.
- W4223470904 cites W1993165149 @default.
- W4223470904 cites W2009576540 @default.
- W4223470904 cites W2033586326 @default.
- W4223470904 cites W2036897871 @default.
- W4223470904 cites W2039289317 @default.
- W4223470904 cites W2059968749 @default.
- W4223470904 cites W2060608189 @default.
- W4223470904 cites W2061846271 @default.
- W4223470904 cites W2072466432 @default.
- W4223470904 cites W2084990854 @default.
- W4223470904 cites W2089894746 @default.
- W4223470904 cites W2089924497 @default.
- W4223470904 cites W2096465161 @default.
- W4223470904 cites W2098651180 @default.
- W4223470904 cites W2101071606 @default.
- W4223470904 cites W2102619694 @default.
- W4223470904 cites W2108234281 @default.
- W4223470904 cites W2110172970 @default.
- W4223470904 cites W2113999582 @default.
- W4223470904 cites W2116236561 @default.
- W4223470904 cites W2123973342 @default.
- W4223470904 cites W2126958666 @default.
- W4223470904 cites W2128016314 @default.
- W4223470904 cites W2129785061 @default.
- W4223470904 cites W2138207763 @default.
- W4223470904 cites W2141458291 @default.
- W4223470904 cites W2146573461 @default.
- W4223470904 cites W2157009395 @default.
- W4223470904 cites W2160051211 @default.
- W4223470904 cites W2169456326 @default.
- W4223470904 cites W2170551349 @default.
- W4223470904 cites W2171808845 @default.
- W4223470904 cites W2175884649 @default.
- W4223470904 cites W2239511084 @default.
- W4223470904 cites W2341539131 @default.
- W4223470904 cites W2345850272 @default.
- W4223470904 cites W2439189013 @default.
- W4223470904 cites W2466171108 @default.
- W4223470904 cites W2565355131 @default.
- W4223470904 cites W2596157468 @default.
- W4223470904 cites W2763042654 @default.
- W4223470904 cites W2765753520 @default.
- W4223470904 cites W2789843538 @default.
- W4223470904 cites W2948444256 @default.
- W4223470904 cites W2952793680 @default.
- W4223470904 cites W2974807176 @default.
- W4223470904 cites W2984285153 @default.
- W4223470904 cites W3038942960 @default.
- W4223470904 doi "https://doi.org/10.1038/s42003-022-03250-x" @default.
- W4223470904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35411071" @default.
- W4223470904 hasPublicationYear "2022" @default.
- W4223470904 type Work @default.
- W4223470904 citedByCount "0" @default.
- W4223470904 crossrefType "journal-article" @default.
- W4223470904 hasAuthorship W4223470904A5002970730 @default.
- W4223470904 hasAuthorship W4223470904A5008473414 @default.
- W4223470904 hasAuthorship W4223470904A5015800351 @default.
- W4223470904 hasAuthorship W4223470904A5033724435 @default.
- W4223470904 hasAuthorship W4223470904A5044887449 @default.
- W4223470904 hasAuthorship W4223470904A5052960352 @default.
- W4223470904 hasAuthorship W4223470904A5053761367 @default.
- W4223470904 hasAuthorship W4223470904A5054735033 @default.
- W4223470904 hasAuthorship W4223470904A5057138426 @default.
- W4223470904 hasAuthorship W4223470904A5058977705 @default.
- W4223470904 hasAuthorship W4223470904A5062891826 @default.
- W4223470904 hasAuthorship W4223470904A5065813780 @default.
- W4223470904 hasBestOaLocation W42234709041 @default.
- W4223470904 hasConcept C104317684 @default.
- W4223470904 hasConcept C172827444 @default.
- W4223470904 hasConcept C194993378 @default.
- W4223470904 hasConcept C2776745794 @default.
- W4223470904 hasConcept C2776915012 @default.
- W4223470904 hasConcept C41091548 @default.
- W4223470904 hasConcept C54355233 @default.
- W4223470904 hasConcept C67705224 @default.
- W4223470904 hasConcept C83640560 @default.