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• W4223470935 abstract "A series of new acylthiourea derivatives were synthesized and characterized. The results of preliminary herbicidal activity tests showed that most compounds had good herbicidal activity against Digitaria adscendens and Amaranthus retroflexus, especially for compounds 4b (N-(2-chloro-4-methylsulfonylbenzoyl)-N’-(2-chlorophenyl) thiourea) and 4f (N-(2-chloro-4-methylsulfonylbenzoyl)-N’-(2,3-dichlorophenyl) thiourea). In vivo acetylhydroxylate synthase (AHAS) enzyme activity inhibition tests showed that all compounds had inhibitory activities against the enzyme at a concentration of 100 mg·L−1, with the highest inhibition rate up to 37.05% (compound 4f). In addition, molecular docking analysis was conducted by using the yeast AHAS as the target enzyme. The results of molecular docking were similar to the bioassay experiments, showing compounds 4b and 4f were potent inhibitors of AHAS." @default.
• W4223470935 created "2022-04-15" @default.
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• W4223470935 date "2022-04-12" @default.
• W4223470935 modified "2023-10-17" @default.
• W4223470935 title "Synthesis, herbicidal activity study, and molecular docking of novel acylthiourea derivatives" @default.
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• W4223470935 doi "https://doi.org/10.1080/10426507.2022.2063289" @default.
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