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- W4223472534 endingPage "102721" @default.
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- W4223472534 abstract "Gene therapy is designed to cure various diseases resulting from genetic defects. Currently, recombinant adeno-associated viral vectors (rAAV) are the vehicles of choice for therapeutic gene delivery in vivo. To date, manufacturing sufficient rAAV product to meet rapidly expanding clinical demand remains a bottleneck in the industry. In the past decade, multiple production platforms have been rapidly implemented with encouraging improvements in productivity and scalability. In this review, we discuss the advantages and limitations of the most popular production platforms in the industry with a focus on the cell culture process scale-up." @default.
- W4223472534 created "2022-04-15" @default.
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- W4223472534 date "2022-06-01" @default.
- W4223472534 modified "2023-10-14" @default.
- W4223472534 title "Gene therapy: challenges in cell culture scale-up" @default.
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- W4223472534 doi "https://doi.org/10.1016/j.copbio.2022.102721" @default.
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