Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223477034> ?p ?o ?g. }
- W4223477034 abstract "The present study aimed to assess the value of human umbilical cord mesenchymal stem cells (hUC-MSCs) for the treatment of diabetes-induced erectile dysfunction (DMED). We established a type 1 diabetes model through intra-abdominal streptozotocin injection. After 10 weeks, an apomorphine test was performed to screen the rats for erectile dysfunction (ED). The rats were divided into three groups: normal control group (n = 10), DMED group (n = 9) and DMED+hUC-MSC group (n = 9). After 4 weeks of hUC-MSC therapy, erectile function was evaluated by intracavernous pressure measurements, and penile tissue collagen and smooth muscle were examined by haematoxylin-eosin and Masson's trichrome staining. In addition, western blotting, immunohistochemistry and RT-PCR analysis of TLR4, VEGF and eNOS were performed. The results showed that hUC-MSC treatment restored erectile function (p < .05) and reversed the smooth muscle/collagen ratio changes of DMED rats (p < .05). Furthermore, hUC-MSC treatment inhibited the expression of TLR4 (p < .05) and enhanced VEGF and eNOS expression (p < .05). In conclusion, hUC-MSC treatment restored the erectile function of diabetic rats by inhibiting TLR4, improving corpora cavernosa fibrosis, and increasing VEGF and eNOS expression." @default.
- W4223477034 created "2022-04-15" @default.
- W4223477034 creator A5011757806 @default.
- W4223477034 creator A5017248601 @default.
- W4223477034 creator A5023904709 @default.
- W4223477034 creator A5045439281 @default.
- W4223477034 creator A5047917738 @default.
- W4223477034 creator A5048620377 @default.
- W4223477034 creator A5049948972 @default.
- W4223477034 creator A5052637085 @default.
- W4223477034 creator A5061280507 @default.
- W4223477034 creator A5063481044 @default.
- W4223477034 creator A5075350348 @default.
- W4223477034 date "2022-04-12" @default.
- W4223477034 modified "2023-09-26" @default.
- W4223477034 title "A study of diabetes‐induced erectile dysfunction treated with human umbilical cord mesenchymal stem cells" @default.
- W4223477034 cites W1704132156 @default.
- W4223477034 cites W1968323108 @default.
- W4223477034 cites W1979521526 @default.
- W4223477034 cites W2011023954 @default.
- W4223477034 cites W2015426450 @default.
- W4223477034 cites W2022423369 @default.
- W4223477034 cites W2080791333 @default.
- W4223477034 cites W2087933507 @default.
- W4223477034 cites W2110830206 @default.
- W4223477034 cites W2112642432 @default.
- W4223477034 cites W2155890632 @default.
- W4223477034 cites W2170041093 @default.
- W4223477034 cites W2268799892 @default.
- W4223477034 cites W2275638130 @default.
- W4223477034 cites W2297865121 @default.
- W4223477034 cites W2568015330 @default.
- W4223477034 cites W2736597065 @default.
- W4223477034 cites W2761798890 @default.
- W4223477034 cites W2766971919 @default.
- W4223477034 cites W2783255467 @default.
- W4223477034 cites W2883384914 @default.
- W4223477034 cites W2889312210 @default.
- W4223477034 cites W2890602632 @default.
- W4223477034 cites W2901505320 @default.
- W4223477034 cites W2946720733 @default.
- W4223477034 cites W3032527021 @default.
- W4223477034 cites W3109409752 @default.
- W4223477034 cites W3169040095 @default.
- W4223477034 cites W3210792010 @default.
- W4223477034 cites W4211128726 @default.
- W4223477034 cites W4242800681 @default.
- W4223477034 doi "https://doi.org/10.1111/and.14440" @default.
- W4223477034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35415927" @default.
- W4223477034 hasPublicationYear "2022" @default.
- W4223477034 type Work @default.
- W4223477034 citedByCount "1" @default.
- W4223477034 countsByYear W42234770342022 @default.
- W4223477034 crossrefType "journal-article" @default.
- W4223477034 hasAuthorship W4223477034A5011757806 @default.
- W4223477034 hasAuthorship W4223477034A5017248601 @default.
- W4223477034 hasAuthorship W4223477034A5023904709 @default.
- W4223477034 hasAuthorship W4223477034A5045439281 @default.
- W4223477034 hasAuthorship W4223477034A5047917738 @default.
- W4223477034 hasAuthorship W4223477034A5048620377 @default.
- W4223477034 hasAuthorship W4223477034A5049948972 @default.
- W4223477034 hasAuthorship W4223477034A5052637085 @default.
- W4223477034 hasAuthorship W4223477034A5061280507 @default.
- W4223477034 hasAuthorship W4223477034A5063481044 @default.
- W4223477034 hasAuthorship W4223477034A5075350348 @default.
- W4223477034 hasConcept C105702510 @default.
- W4223477034 hasConcept C125473707 @default.
- W4223477034 hasConcept C126322002 @default.
- W4223477034 hasConcept C126894567 @default.
- W4223477034 hasConcept C134018914 @default.
- W4223477034 hasConcept C142724271 @default.
- W4223477034 hasConcept C163031210 @default.
- W4223477034 hasConcept C16685009 @default.
- W4223477034 hasConcept C198826908 @default.
- W4223477034 hasConcept C204232928 @default.
- W4223477034 hasConcept C2776955114 @default.
- W4223477034 hasConcept C2777622882 @default.
- W4223477034 hasConcept C2778326061 @default.
- W4223477034 hasConcept C2779929075 @default.
- W4223477034 hasConcept C2780559512 @default.
- W4223477034 hasConcept C519581460 @default.
- W4223477034 hasConcept C555293320 @default.
- W4223477034 hasConcept C71924100 @default.
- W4223477034 hasConceptScore W4223477034C105702510 @default.
- W4223477034 hasConceptScore W4223477034C125473707 @default.
- W4223477034 hasConceptScore W4223477034C126322002 @default.
- W4223477034 hasConceptScore W4223477034C126894567 @default.
- W4223477034 hasConceptScore W4223477034C134018914 @default.
- W4223477034 hasConceptScore W4223477034C142724271 @default.
- W4223477034 hasConceptScore W4223477034C163031210 @default.
- W4223477034 hasConceptScore W4223477034C16685009 @default.
- W4223477034 hasConceptScore W4223477034C198826908 @default.
- W4223477034 hasConceptScore W4223477034C204232928 @default.
- W4223477034 hasConceptScore W4223477034C2776955114 @default.
- W4223477034 hasConceptScore W4223477034C2777622882 @default.
- W4223477034 hasConceptScore W4223477034C2778326061 @default.
- W4223477034 hasConceptScore W4223477034C2779929075 @default.
- W4223477034 hasConceptScore W4223477034C2780559512 @default.
- W4223477034 hasConceptScore W4223477034C519581460 @default.
- W4223477034 hasConceptScore W4223477034C555293320 @default.