FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223478942> ?p ?o ?g. }

• W4223478942 endingPage "995" @default.
• W4223478942 startingPage "985" @default.
• W4223478942 abstract "Phosphatase and tensin homolog (PTEN)-induced kinase 1 (Pink1) is regarded as a tumor suppressor and plays an important role in cancer cell biology, while relatively few studies have examined Pink1 in breast cancer, especially in vivo. The aims of this study were to investigate Pink1 expression in different subtypes of breast cancer tissues and cell lines and explore the effect of Pink1 protein on breast cancer. In these experiments, Pink1 expression was investigated using the tissue microarray immunohistochemistry (TMA-IHC) method in 150 samples of breast cancer tissues with different subtypes, and strong staining of Pink1 was significantly correlated with the histological grade of breast cancer (p = 0.015). In addition, Pink1 messenger RNA (mRNA) displayed much higher expression levels in breast cancer cell lines than in MCF-10A breast epithelial cells. Moreover, proteomic data obtained by isobaric tags for relative and absolute quantification (iTRAQ) showed that Pink1 deletion induced a distinct proteomic profile in MDA-MB-231 cells, and enrichment analysis showed that the differential proteins were concentrated mainly in energy metabolism-related pathways. Moreover, Seahorse XF analysis showed that Pink1 knockout reduced the glycolytic ability of MDA-MB-231 cells. Our findings indicated that Pink1 may be an indicator of malignancy in breast cancer and that it presents oncogenic properties in breast cancer, which raises another perspective for understanding the regulatory role of Pink1 in breast cancer." @default.
• W4223478942 created "2022-04-15" @default.
• W4223478942 creator A5006746441 @default.
• W4223478942 creator A5019474273 @default.
• W4223478942 creator A5034924571 @default.
• W4223478942 creator A5036880568 @default.
• W4223478942 creator A5036914882 @default.
• W4223478942 creator A5040246924 @default.
• W4223478942 creator A5048379858 @default.
• W4223478942 date "2022-04-11" @default.
• W4223478942 modified "2023-09-27" @default.
• W4223478942 title "<i>Pink1</i> promotes cell proliferation and affects glycolysis in breast cancer" @default.
• W4223478942 cites W1836906403 @default.
• W4223478942 cites W1963757800 @default.
• W4223478942 cites W1970436894 @default.
• W4223478942 cites W1989729510 @default.
• W4223478942 cites W1993733276 @default.
• W4223478942 cites W2002763080 @default.
• W4223478942 cites W2014058353 @default.
• W4223478942 cites W2031305815 @default.
• W4223478942 cites W2035799305 @default.
• W4223478942 cites W2044702943 @default.
• W4223478942 cites W2062963598 @default.
• W4223478942 cites W2071133957 @default.
• W4223478942 cites W2090963058 @default.
• W4223478942 cites W2092138471 @default.
• W4223478942 cites W2114941442 @default.
• W4223478942 cites W2132893003 @default.
• W4223478942 cites W2136388422 @default.
• W4223478942 cites W2142460292 @default.
• W4223478942 cites W2162360603 @default.
• W4223478942 cites W2169041356 @default.
• W4223478942 cites W2405190761 @default.
• W4223478942 cites W2467807723 @default.
• W4223478942 cites W2791055381 @default.
• W4223478942 cites W2807926991 @default.
• W4223478942 cites W2890056801 @default.
• W4223478942 cites W2894278828 @default.
• W4223478942 cites W2953434846 @default.
• W4223478942 cites W2981848316 @default.
• W4223478942 cites W2991718894 @default.
• W4223478942 cites W3018368987 @default.
• W4223478942 cites W3102057461 @default.
• W4223478942 cites W3138703087 @default.
• W4223478942 cites W3156386965 @default.
• W4223478942 cites W3204068085 @default.
• W4223478942 doi "https://doi.org/10.1177/15353702221082613" @default.
• W4223478942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35410525" @default.
• W4223478942 hasPublicationYear "2022" @default.
• W4223478942 type Work @default.
• W4223478942 citedByCount "1" @default.
• W4223478942 countsByYear W42234789422023 @default.
• W4223478942 crossrefType "journal-article" @default.
• W4223478942 hasAuthorship W4223478942A5006746441 @default.
• W4223478942 hasAuthorship W4223478942A5019474273 @default.
• W4223478942 hasAuthorship W4223478942A5034924571 @default.
• W4223478942 hasAuthorship W4223478942A5036880568 @default.
• W4223478942 hasAuthorship W4223478942A5036914882 @default.
• W4223478942 hasAuthorship W4223478942A5040246924 @default.
• W4223478942 hasAuthorship W4223478942A5048379858 @default.
• W4223478942 hasBestOaLocation W42234789422 @default.
• W4223478942 hasConcept C121608353 @default.
• W4223478942 hasConcept C190283241 @default.
• W4223478942 hasConcept C203014093 @default.
• W4223478942 hasConcept C203522944 @default.
• W4223478942 hasConcept C204232928 @default.
• W4223478942 hasConcept C2776804853 @default.
• W4223478942 hasConcept C2777609662 @default.
• W4223478942 hasConcept C2779324830 @default.
• W4223478942 hasConcept C2779549131 @default.
• W4223478942 hasConcept C502942594 @default.
• W4223478942 hasConcept C530470458 @default.
• W4223478942 hasConcept C54355233 @default.
• W4223478942 hasConcept C55493867 @default.
• W4223478942 hasConcept C555283112 @default.
• W4223478942 hasConcept C62478195 @default.
• W4223478942 hasConcept C86554907 @default.
• W4223478942 hasConcept C86803240 @default.
• W4223478942 hasConcept C95444343 @default.
• W4223478942 hasConcept C96232424 @default.
• W4223478942 hasConceptScore W4223478942C121608353 @default.
• W4223478942 hasConceptScore W4223478942C190283241 @default.
• W4223478942 hasConceptScore W4223478942C203014093 @default.
• W4223478942 hasConceptScore W4223478942C203522944 @default.
• W4223478942 hasConceptScore W4223478942C204232928 @default.
• W4223478942 hasConceptScore W4223478942C2776804853 @default.
• W4223478942 hasConceptScore W4223478942C2777609662 @default.
• W4223478942 hasConceptScore W4223478942C2779324830 @default.
• W4223478942 hasConceptScore W4223478942C2779549131 @default.
• W4223478942 hasConceptScore W4223478942C502942594 @default.
• W4223478942 hasConceptScore W4223478942C530470458 @default.
• W4223478942 hasConceptScore W4223478942C54355233 @default.
• W4223478942 hasConceptScore W4223478942C55493867 @default.
• W4223478942 hasConceptScore W4223478942C555283112 @default.
• W4223478942 hasConceptScore W4223478942C62478195 @default.
• W4223478942 hasConceptScore W4223478942C86554907 @default.
• W4223478942 hasConceptScore W4223478942C86803240 @default.
• W4223478942 hasConceptScore W4223478942C95444343 @default.

• next