FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223481017> ?p ?o ?g. }

• W4223481017 abstract "Bisphosphonates (BPs) are commonly used in the treatment of osteoporosis and are effective in the prevention of fragility fracture. Long-term use has been associated with the development of atypical femur fractures (AFFs) and osteonecrosis of the jaw (ONJ). Drug holidays seek to reduce the risk of insufficiency fractures (AFFs) while maintaining durable effects of long-term treatment in the prevention of fragility fracture. Guidelines suggest that BP drug holidays be considered after 3 to 5 years. However individual factors impacting this decision and outcomes are unclear. This review examines key factors in the planning of a safe BP drug holiday and surrogate markers of fracture risk in patients discontinuing treatment. Fifteen randomized control trials and 19 real-world studies were included, including nationwide prospective studies from several countries. Increases in bone turnover markers (BTMs) and reductions in bone mineral density (BMD) were generally observed during BP drug holidays. Resurgent bone turnover was problematic in high-risk patients in whom fractures recurred as early as 12 months following a drug holiday. Risk factors for holiday-related fractures included older age, low hip BMD, underweight, low medication adherence, and prevalent/incident fractures. Zoledronic acid conferred the most durable reduction in fractures, particularly after six annual infusions. Five years of alendronate was insufficient in preventing vertebral fractures in high-risk patients embarking on a drug holiday. Relatively faster offset of antiresorptive effect was seen in risedronate users with more frequent fractures than alendronate during a drug holiday. Studies directly counterbalancing effects of long-term treatment on AFF risk versus drug holiday outcomes in the same population were lacking. In the absence of persistently high fracture risk and following a specific treatment duration dependent on the BP used, drug holidays are safe and mitigate the risk of AFF. However, anti-resorptive effects diminish over time; ongoing monitoring and careful planning of BP resumption is necessary. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research." @default.
• W4223481017 created "2022-04-15" @default.
• W4223481017 creator A5032153476 @default.
• W4223481017 creator A5037404710 @default.
• W4223481017 creator A5082276935 @default.
• W4223481017 date "2022-05-24" @default.
• W4223481017 modified "2023-10-10" @default.
• W4223481017 title "Bisphosphonate Drug Holidays: Evidence From Clinical Trials and Real‐World Studies" @default.
• W4223481017 cites W1621696727 @default.
• W4223481017 cites W1777836280 @default.
• W4223481017 cites W1969564030 @default.
• W4223481017 cites W1984754135 @default.
• W4223481017 cites W1985576983 @default.
• W4223481017 cites W1990771263 @default.
• W4223481017 cites W1994313426 @default.
• W4223481017 cites W2001013535 @default.
• W4223481017 cites W2005960379 @default.
• W4223481017 cites W2019292020 @default.
• W4223481017 cites W2025672294 @default.
• W4223481017 cites W2040386786 @default.
• W4223481017 cites W2049146115 @default.
• W4223481017 cites W2050268374 @default.
• W4223481017 cites W2055213889 @default.
• W4223481017 cites W2056922231 @default.
• W4223481017 cites W2057332307 @default.
• W4223481017 cites W2069854575 @default.
• W4223481017 cites W2081887629 @default.
• W4223481017 cites W2099244701 @default.
• W4223481017 cites W2102385904 @default.
• W4223481017 cites W2103609942 @default.
• W4223481017 cites W2104949625 @default.
• W4223481017 cites W2106406207 @default.
• W4223481017 cites W2107494198 @default.
• W4223481017 cites W2112363729 @default.
• W4223481017 cites W2118689243 @default.
• W4223481017 cites W2123171945 @default.
• W4223481017 cites W2134304734 @default.
• W4223481017 cites W2135327653 @default.
• W4223481017 cites W2150904792 @default.
• W4223481017 cites W2157362302 @default.
• W4223481017 cites W2157979607 @default.
• W4223481017 cites W2163058169 @default.
• W4223481017 cites W2163852287 @default.
• W4223481017 cites W2168776590 @default.
• W4223481017 cites W2171709369 @default.
• W4223481017 cites W2172119280 @default.
• W4223481017 cites W2191244879 @default.
• W4223481017 cites W2283368741 @default.
• W4223481017 cites W2531903877 @default.
• W4223481017 cites W2559809466 @default.
• W4223481017 cites W2609235839 @default.
• W4223481017 cites W2753310383 @default.
• W4223481017 cites W2794358356 @default.
• W4223481017 cites W2797111169 @default.
• W4223481017 cites W2837260135 @default.
• W4223481017 cites W2889208018 @default.
• W4223481017 cites W2893745569 @default.
• W4223481017 cites W2909924281 @default.
• W4223481017 cites W2954352310 @default.
• W4223481017 cites W3003305559 @default.
• W4223481017 cites W3023175125 @default.
• W4223481017 cites W3025411177 @default.
• W4223481017 cites W3028962416 @default.
• W4223481017 cites W3035966048 @default.
• W4223481017 cites W3043800126 @default.
• W4223481017 cites W3046398794 @default.
• W4223481017 cites W3075871984 @default.
• W4223481017 cites W3098184854 @default.
• W4223481017 cites W3107343092 @default.
• W4223481017 cites W3120630121 @default.
• W4223481017 cites W3126758856 @default.
• W4223481017 cites W3127350542 @default.
• W4223481017 cites W3178898664 @default.
• W4223481017 cites W3197162350 @default.
• W4223481017 cites W3201827996 @default.
• W4223481017 cites W3204523832 @default.
• W4223481017 cites W3206559390 @default.
• W4223481017 cites W4207033134 @default.
• W4223481017 cites W4210365181 @default.
• W4223481017 cites W4225283309 @default.
• W4223481017 cites W4256049814 @default.
• W4223481017 doi "https://doi.org/10.1002/jbm4.10629" @default.
• W4223481017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35720669" @default.
• W4223481017 hasPublicationYear "2022" @default.
• W4223481017 type Work @default.
• W4223481017 citedByCount "10" @default.
• W4223481017 countsByYear W42234810172022 @default.
• W4223481017 countsByYear W42234810172023 @default.
• W4223481017 crossrefType "journal-article" @default.
• W4223481017 hasAuthorship W4223481017A5032153476 @default.
• W4223481017 hasAuthorship W4223481017A5037404710 @default.
• W4223481017 hasAuthorship W4223481017A5082276935 @default.
• W4223481017 hasBestOaLocation W42234810171 @default.
• W4223481017 hasConcept C126322002 @default.
• W4223481017 hasConcept C140206745 @default.
• W4223481017 hasConcept C141071460 @default.
• W4223481017 hasConcept C170033053 @default.
• W4223481017 hasConcept C187212893 @default.
• W4223481017 hasConcept C2776326535 @default.
• W4223481017 hasConcept C2776541429 @default.

• next