FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223485964> ?p ?o ?g. }

• W4223485964 endingPage "1044" @default.
• W4223485964 startingPage "1037" @default.
• W4223485964 abstract "Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by disturbed cellular and humoral immune responses. Dysregulations of immune system and immunosuppressive medications predispose SLE patients to infection. This study aims to investigate the alterations and absolute concentrations of lymphocyte subpopulations in SLE patients with different infection and their responses of low-dose IL-2 therapy.A total of 333 patients with SLE without recent infection, 162 patients suffering infection, and age and sex-matched 132 healthy controls (HCs) were recruited. Of them, 54 SLE patients (including 41 non-infected group and 13 infected group) received a 5-day course of low-dose IL-2 administration at a dose of 0.5 million IU per day. Lymphocyte subpopulations were analyzed by flow cytometry.Patients with SLE had lower levels of lymphocyte subpopulations in peripheral blood such as T, B, NK, CD4 + T, CD8+ T, Th1, Th2, Th17, and Treg cells, and the reduction in these cells was more obvious in patients with infection (p <.05 to p <.01). Low-dose IL-2 effectively expanded T (p <.001), B (p <.001), CD4 + T (p <.01), CD8 + T (p <.001), Th1 (p <.01), Th17 (p <.1), and Treg cells (p <.01) of SLE patients, these cells were comparable to that of HCs after the IL-2 treatment.Patients with SLE had insufficiency of circulating lymphocyte subsets. This phenomenon was more obverse in those accompanying infection, suggesting the low concentration of lymphocytes may be used as indicators of high infection risk in SLE patients. Low-dose IL-2 induced expansion of Treg cells and NK cells, which may contribute to the restoration of immune homeostasis in SLE patients." @default.
• W4223485964 created "2022-04-15" @default.
• W4223485964 creator A5019018136 @default.
• W4223485964 creator A5023236283 @default.
• W4223485964 creator A5035260546 @default.
• W4223485964 creator A5052960352 @default.
• W4223485964 creator A5054352845 @default.
• W4223485964 creator A5059981148 @default.
• W4223485964 creator A5063857532 @default.
• W4223485964 creator A5064233769 @default.
• W4223485964 creator A5075675835 @default.
• W4223485964 date "2022-04-26" @default.
• W4223485964 modified "2023-09-26" @default.
• W4223485964 title "Low-dose IL-2 therapy limits the reduction in absolute numbers of peripheral lymphocytes in systemic lupus erythematosus patients with infection" @default.
• W4223485964 cites W1598902445 @default.
• W4223485964 cites W1606361567 @default.
• W4223485964 cites W1836011677 @default.
• W4223485964 cites W1970246068 @default.
• W4223485964 cites W1976496178 @default.
• W4223485964 cites W1981610922 @default.
• W4223485964 cites W1996128058 @default.
• W4223485964 cites W1998189366 @default.
• W4223485964 cites W2009250344 @default.
• W4223485964 cites W2031291844 @default.
• W4223485964 cites W2049345643 @default.
• W4223485964 cites W2049785440 @default.
• W4223485964 cites W2052404616 @default.
• W4223485964 cites W2053085401 @default.
• W4223485964 cites W2060998877 @default.
• W4223485964 cites W2061053690 @default.
• W4223485964 cites W2070317421 @default.
• W4223485964 cites W2070527591 @default.
• W4223485964 cites W2072127157 @default.
• W4223485964 cites W2085106134 @default.
• W4223485964 cites W2088340307 @default.
• W4223485964 cites W2097525877 @default.
• W4223485964 cites W2098052315 @default.
• W4223485964 cites W2102758999 @default.
• W4223485964 cites W2103495463 @default.
• W4223485964 cites W2120813964 @default.
• W4223485964 cites W2155957466 @default.
• W4223485964 cites W2166432539 @default.
• W4223485964 cites W2171887211 @default.
• W4223485964 cites W2177646845 @default.
• W4223485964 cites W2296460211 @default.
• W4223485964 cites W2298376141 @default.
• W4223485964 cites W2400862784 @default.
• W4223485964 cites W2477823035 @default.
• W4223485964 cites W2486559230 @default.
• W4223485964 cites W2549310922 @default.
• W4223485964 cites W2582318172 @default.
• W4223485964 cites W2608332984 @default.
• W4223485964 cites W2736017161 @default.
• W4223485964 cites W2747187550 @default.
• W4223485964 cites W2766239492 @default.
• W4223485964 cites W2773787568 @default.
• W4223485964 cites W2884986593 @default.
• W4223485964 cites W2950281866 @default.
• W4223485964 cites W2967201812 @default.
• W4223485964 cites W2969663273 @default.
• W4223485964 cites W2972219493 @default.
• W4223485964 cites W2973404796 @default.
• W4223485964 cites W3023802284 @default.
• W4223485964 cites W3095989000 @default.
• W4223485964 cites W3204847426 @default.
• W4223485964 cites W3210649923 @default.
• W4223485964 cites W3211664676 @default.
• W4223485964 cites W3213116552 @default.
• W4223485964 doi "https://doi.org/10.1080/03007995.2022.2065145" @default.
• W4223485964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35414310" @default.
• W4223485964 hasPublicationYear "2022" @default.
• W4223485964 type Work @default.
• W4223485964 citedByCount "2" @default.
• W4223485964 countsByYear W42234859642023 @default.
• W4223485964 crossrefType "journal-article" @default.
• W4223485964 hasAuthorship W4223485964A5019018136 @default.
• W4223485964 hasAuthorship W4223485964A5023236283 @default.
• W4223485964 hasAuthorship W4223485964A5035260546 @default.
• W4223485964 hasAuthorship W4223485964A5052960352 @default.
• W4223485964 hasAuthorship W4223485964A5054352845 @default.
• W4223485964 hasAuthorship W4223485964A5059981148 @default.
• W4223485964 hasAuthorship W4223485964A5063857532 @default.
• W4223485964 hasAuthorship W4223485964A5064233769 @default.
• W4223485964 hasAuthorship W4223485964A5075675835 @default.
• W4223485964 hasBestOaLocation W42234859641 @default.
• W4223485964 hasConcept C126322002 @default.
• W4223485964 hasConcept C159654299 @default.
• W4223485964 hasConcept C167672396 @default.
• W4223485964 hasConcept C203014093 @default.
• W4223485964 hasConcept C2775915377 @default.
• W4223485964 hasConcept C2777761686 @default.
• W4223485964 hasConcept C553184892 @default.
• W4223485964 hasConcept C71924100 @default.
• W4223485964 hasConcept C8891405 @default.
• W4223485964 hasConceptScore W4223485964C126322002 @default.
• W4223485964 hasConceptScore W4223485964C159654299 @default.
• W4223485964 hasConceptScore W4223485964C167672396 @default.
• W4223485964 hasConceptScore W4223485964C203014093 @default.

• next