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- W4223500725 abstract "Abstract The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays essential roles in tumor development and metastasis. The clinical outcomes of tumors are often closely related to individual differences in the patient TME. Therefore, reprogramming TME cells and their intercellular communication is an attractive and promising strategy for cancer therapy. TME cells consist of immune and nonimmune cells. These cells need to be manipulated precisely and safely to improve cancer therapy. Furthermore, it is encouraging that this field has rapidly developed in recent years with the advent and development of gene editing technologies. In this review, we briefly introduce gene editing technologies and systematically summarize their applications in the TME for precision cancer therapy, including the reprogramming of TME cells and their intercellular communication. TME cell reprogramming can regulate cell differentiation, proliferation, and function. Moreover, reprogramming the intercellular communication of TME cells can optimize immune infiltration and the specific recognition of tumor cells by immune cells. Thus, gene editing will pave the way for further breakthroughs in precision cancer therapy." @default.
- W4223500725 created "2022-04-15" @default.
- W4223500725 creator A5002608004 @default.
- W4223500725 creator A5020286464 @default.
- W4223500725 creator A5022402645 @default.
- W4223500725 creator A5035915037 @default.
- W4223500725 creator A5039727047 @default.
- W4223500725 creator A5060497988 @default.
- W4223500725 creator A5061425723 @default.
- W4223500725 creator A5081487068 @default.
- W4223500725 date "2022-04-11" @default.
- W4223500725 modified "2023-10-17" @default.
- W4223500725 title "Reprogramming the tumor microenvironment by genome editing for precision cancer therapy" @default.
- W4223500725 cites W1554274383 @default.
- W4223500725 cites W1556946899 @default.
- W4223500725 cites W1703091204 @default.
- W4223500725 cites W1800095175 @default.
- W4223500725 cites W1829424702 @default.
- W4223500725 cites W1839053269 @default.
- W4223500725 cites W1881216623 @default.
- W4223500725 cites W1950572133 @default.
- W4223500725 cites W1966542058 @default.
- W4223500725 cites W1967884480 @default.
- W4223500725 cites W1971620413 @default.
- W4223500725 cites W1973756395 @default.
- W4223500725 cites W1974271244 @default.
- W4223500725 cites W1978471137 @default.
- W4223500725 cites W1979615066 @default.
- W4223500725 cites W1980931199 @default.
- W4223500725 cites W1982323892 @default.
- W4223500725 cites W1985126564 @default.
- W4223500725 cites W1985294654 @default.
- W4223500725 cites W1986090622 @default.
- W4223500725 cites W1986359477 @default.
- W4223500725 cites W1986856090 @default.
- W4223500725 cites W1987165863 @default.
- W4223500725 cites W1987516241 @default.
- W4223500725 cites W1996879480 @default.
- W4223500725 cites W2001642752 @default.
- W4223500725 cites W2002539186 @default.
- W4223500725 cites W2004655285 @default.
- W4223500725 cites W2006202814 @default.
- W4223500725 cites W2006344933 @default.
- W4223500725 cites W2008188798 @default.
- W4223500725 cites W2011962069 @default.
- W4223500725 cites W2012143830 @default.
- W4223500725 cites W2015587858 @default.
- W4223500725 cites W2016523043 @default.
- W4223500725 cites W2016789384 @default.
- W4223500725 cites W2018775174 @default.
- W4223500725 cites W2018809204 @default.
- W4223500725 cites W2020646453 @default.
- W4223500725 cites W2024449521 @default.
- W4223500725 cites W2024530814 @default.
- W4223500725 cites W2026659207 @default.
- W4223500725 cites W2026850768 @default.
- W4223500725 cites W2027053879 @default.
- W4223500725 cites W2029229136 @default.
- W4223500725 cites W2030199762 @default.
- W4223500725 cites W2031409539 @default.
- W4223500725 cites W2032474425 @default.
- W4223500725 cites W2033278321 @default.
- W4223500725 cites W2036518895 @default.
- W4223500725 cites W2036680234 @default.
- W4223500725 cites W2036922744 @default.
- W4223500725 cites W2044339772 @default.
- W4223500725 cites W2046562334 @default.
- W4223500725 cites W2046813754 @default.
- W4223500725 cites W2049601932 @default.
- W4223500725 cites W2050558251 @default.
- W4223500725 cites W2051962533 @default.
- W4223500725 cites W2056315817 @default.
- W4223500725 cites W2059225878 @default.
- W4223500725 cites W2059431619 @default.
- W4223500725 cites W2061184966 @default.
- W4223500725 cites W2072703892 @default.
- W4223500725 cites W2076771030 @default.
- W4223500725 cites W2077994554 @default.
- W4223500725 cites W2081447858 @default.
- W4223500725 cites W2081639190 @default.
- W4223500725 cites W2084647551 @default.
- W4223500725 cites W2087654677 @default.
- W4223500725 cites W2087766713 @default.
- W4223500725 cites W2090831287 @default.
- W4223500725 cites W2097562780 @default.
- W4223500725 cites W2098236252 @default.
- W4223500725 cites W2098778820 @default.
- W4223500725 cites W2101037339 @default.
- W4223500725 cites W2101206430 @default.
- W4223500725 cites W2102168616 @default.
- W4223500725 cites W2102944868 @default.
- W4223500725 cites W2103412440 @default.
- W4223500725 cites W2103709809 @default.
- W4223500725 cites W2105443773 @default.
- W4223500725 cites W2105724560 @default.
- W4223500725 cites W2110999048 @default.
- W4223500725 cites W2113051617 @default.
- W4223500725 cites W2113082145 @default.
- W4223500725 cites W2113407988 @default.
- W4223500725 cites W2114027214 @default.