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- W4223505314 abstract "In this study, we establish a population-based human induced pluripotent stem cell (hiPSC) drug screening platform for toxicity assessment. After recruiting 1,000 healthy donors and screening for high-frequency human leukocyte antigen (HLA) haplotypes, we identify 13 HLA-homozygous super donors to represent the population. These super donors are also expected to represent at least 477,611,135 of the global population. By differentiating these representative hiPSCs into cardiomyocytes and neurons we show their utility in a high-throughput toxicity screen. To validate hit compounds, we demonstrate dose-dependent toxicity of the hit compounds and assess functional modulation. We also show reproducible in vivo drug toxicity results using mouse models with select hit compounds. This study shows the feasibility of using a population-based hiPSC drug screening platform to assess cytotoxicity, which can be used as an innovative tool to study inter-population differences in drug toxicity and adverse drug reactions in drug discovery applications." @default.
- W4223505314 created "2022-04-15" @default.
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- W4223505314 date "2022-04-01" @default.
- W4223505314 modified "2023-10-13" @default.
- W4223505314 title "Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons" @default.
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