Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223515049> ?p ?o ?g. }
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- W4223515049 abstract "Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacteria that consist of a growth-inhibiting toxin and its cognate antitoxin. These systems are prevalent in bacterial chromosomes, plasmids, and phage genomes, but individual systems are not highly conserved, even among closely related strains. The biological functions of TA systems have been controversial and enigmatic, although a handful of these systems have been shown to defend bacteria against their viral predators, bacteriophages. Additionally, their patterns of conservation—ubiquitous, but rapidly acquired and lost from genomes—as well as the co-occurrence of some TA systems with known phage defense elements are suggestive of a broader role in mediating phage defense. Here, we review the existing evidence for phage defense mediated by TA systems, highlighting how toxins are activated by phage infection and how toxins disrupt phage replication. We also discuss phage-encoded systems that counteract TA systems, underscoring the ongoing coevolutionary battle between bacteria and phage. We anticipate that TA systems will continue to emerge as central players in the innate immunity of bacteria against phage." @default.
- W4223515049 created "2022-04-15" @default.
- W4223515049 creator A5033024035 @default.
- W4223515049 creator A5061582937 @default.
- W4223515049 date "2022-09-08" @default.
- W4223515049 modified "2023-10-16" @default.
- W4223515049 title "Toxin-Antitoxin Systems as Phage Defense Elements" @default.
- W4223515049 cites W1511169713 @default.
- W4223515049 cites W1511212618 @default.
- W4223515049 cites W1571792874 @default.
- W4223515049 cites W1579399128 @default.
- W4223515049 cites W1599154134 @default.
- W4223515049 cites W1604725832 @default.
- W4223515049 cites W1629906295 @default.
- W4223515049 cites W1666867306 @default.
- W4223515049 cites W17016481 @default.
- W4223515049 cites W1725358412 @default.
- W4223515049 cites W1741082581 @default.
- W4223515049 cites W1822103663 @default.
- W4223515049 cites W1858758914 @default.
- W4223515049 cites W1898420993 @default.
- W4223515049 cites W1922621074 @default.
- W4223515049 cites W1951116384 @default.
- W4223515049 cites W1974053222 @default.
- W4223515049 cites W1977293483 @default.
- W4223515049 cites W1977726874 @default.
- W4223515049 cites W1982583457 @default.
- W4223515049 cites W1985347638 @default.
- W4223515049 cites W1986703858 @default.
- W4223515049 cites W1994219462 @default.
- W4223515049 cites W1998566510 @default.
- W4223515049 cites W2005593489 @default.
- W4223515049 cites W2015036927 @default.
- W4223515049 cites W2015442594 @default.
- W4223515049 cites W2016912614 @default.
- W4223515049 cites W2017145164 @default.
- W4223515049 cites W2021197152 @default.
- W4223515049 cites W2021350676 @default.
- W4223515049 cites W2023985059 @default.
- W4223515049 cites W2041367172 @default.
- W4223515049 cites W2045114886 @default.
- W4223515049 cites W2047158803 @default.
- W4223515049 cites W2051584259 @default.
- W4223515049 cites W2051780892 @default.
- W4223515049 cites W2062119690 @default.
- W4223515049 cites W2063047151 @default.
- W4223515049 cites W2069477714 @default.
- W4223515049 cites W2076554517 @default.
- W4223515049 cites W2083873972 @default.
- W4223515049 cites W2085186163 @default.
- W4223515049 cites W2090486365 @default.
- W4223515049 cites W2095624846 @default.
- W4223515049 cites W2096792353 @default.
- W4223515049 cites W2099326312 @default.
- W4223515049 cites W2103222799 @default.
- W4223515049 cites W2103650497 @default.
- W4223515049 cites W2105753010 @default.
- W4223515049 cites W2107094711 @default.
- W4223515049 cites W2108773632 @default.
- W4223515049 cites W2109898412 @default.
- W4223515049 cites W2110162745 @default.
- W4223515049 cites W2111555302 @default.
- W4223515049 cites W2114946077 @default.
- W4223515049 cites W2122492159 @default.
- W4223515049 cites W2126573196 @default.
- W4223515049 cites W2132401377 @default.
- W4223515049 cites W2141623271 @default.
- W4223515049 cites W2146276053 @default.
- W4223515049 cites W2156539285 @default.
- W4223515049 cites W2158742098 @default.
- W4223515049 cites W2158992333 @default.
- W4223515049 cites W2159620582 @default.
- W4223515049 cites W2161861736 @default.
- W4223515049 cites W2164502256 @default.
- W4223515049 cites W2166489116 @default.
- W4223515049 cites W2168606178 @default.
- W4223515049 cites W2169235657 @default.
- W4223515049 cites W2170305714 @default.
- W4223515049 cites W2229297191 @default.
- W4223515049 cites W2293850138 @default.
- W4223515049 cites W2298249827 @default.
- W4223515049 cites W2384121742 @default.
- W4223515049 cites W2417855243 @default.
- W4223515049 cites W2474500496 @default.
- W4223515049 cites W2525298040 @default.
- W4223515049 cites W2560235780 @default.
- W4223515049 cites W2570615709 @default.
- W4223515049 cites W2583715291 @default.
- W4223515049 cites W2588339775 @default.
- W4223515049 cites W2618294776 @default.
- W4223515049 cites W2756177771 @default.
- W4223515049 cites W2767051074 @default.
- W4223515049 cites W2775828058 @default.
- W4223515049 cites W2783474878 @default.
- W4223515049 cites W2783707461 @default.
- W4223515049 cites W2790625834 @default.
- W4223515049 cites W2806907275 @default.
- W4223515049 cites W2808489725 @default.