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- W4223545281 endingPage "4211" @default.
- W4223545281 startingPage "4211" @default.
- W4223545281 abstract "Spitz neoplasms are a heterogeneous group of melanocytic proliferations with a great variability in the histological characteristics and in the biological behavior. Thanks to recent discoveries, the morpho-molecular landscape of Spitz lineage is becoming clearer, with the identification of subtypes with recurrent features thus providing the basis for a more solid and precise tumor classification. Indeed, specific mutually exclusive driver molecular events, namely HRAS or MAP2K1 mutations, copy number gains of 11p, and fusions involving ALK, ROS, NTRK1, NTRK2, NTRK3, MET, RET, MAP3K8, and BRAF genes, correlate with distinctive histological features. The accumulation of further molecular aberrations, instead, promotes the increasing malignant transformation of Spitz neoplasms. Thus, the detection of a driver genetic alteration can be achieved using the appropriate diagnostic tests chosen according to the histological characteristics of the lesion. This allows the recognition of subtypes with aggressive behavior requiring further molecular investigations. This review provides an update on the morpho-molecular correlations in Spitz neoplasms." @default.
- W4223545281 created "2022-04-15" @default.
- W4223545281 creator A5017928115 @default.
- W4223545281 creator A5045042199 @default.
- W4223545281 date "2022-04-11" @default.
- W4223545281 modified "2023-10-06" @default.
- W4223545281 title "The Morpho-Molecular Landscape of Spitz Neoplasms" @default.
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