FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223550360> ?p ?o ?g. }

• W4223550360 endingPage "e22" @default.
• W4223550360 startingPage "e21" @default.
• W4223550360 abstract "Introduction: Schizophrenia is a chronic mental disease which has a genetic etiology in 80% of the cases. In the last years, about 260 risk genes with a predisposition to schizophrenia have been described, and correlations between single nucleotide polymorphisms (SNPs) of risk genes and the therapeutic efficacy of an antipsychotic treatment/pharmacotherapy resistance have been reported. Methods: In schizophrenia, important risk genes, such as catechol-O-methyl transferase (COMT), monoamine oxidase (MAO A/B), glutamic acid decarboxylase 67 (GAD 67), dysbindin-1 and neuregulin-1 are mentioned. To describe the function of these risk genes, neural networks in the ventral tegmental area, hippocampus and prefrontal cortex are developed. Results: An association between the SNPs of some risk genes and the efficacy of an antipsychotic treatment is reported: SNPs such as rs165599 ( COMT gene), rs1801028 ( D2 receptor gene) and rsSer9 Gly ( D3 receptor gene) are associated with a better antipsychotic treatment efficacy. In this case, a treatment of positive and negative schizophrenic symptoms with risperidone is secured. The rs4680 SNP ( COMT and D2 receptor genes) is associated with antipsychotic-induced dopamine hypersensitivity and pharmacotherapy resistance. The function of the COMT and MAO A/B risk genes is described. In schizophrenia, through a reduced activity in the corresponding enzymes, a decrease in dopamine degradation occurs and hence, via D2 receptors, and dopamine hyperactivity has been observed. The GAD 67 risk gene is linked with GABAergic dysfunction and consequently GABAergic neurons weakly presynaptically inhibit D2 dopaminergic neurons. The D-amino acid oxidase activator (DAOA) risk gene is connected with glutamatergic dysfunction via NMDA receptors. Glutamatergic neurons might exert a weak presynaptic inhibition upon 5-HT2A serotonergic neurons located in the ventral tegmental area and hippocampus. Conclusion: It is important to examine the SNPs of the risk genes involved in schizophrenia to establish a correlation between these SNPs and the efficacy of a determined antipsychotic drug. Thus, schizophrenic patients with a good response to a determined antipsychotic treatment and patients with resistance to this treatment could be well differentiated. The latter patients with pharmacoresistance might be treated with the antipsychotic drug clozapine and an additional treatment with cariprazine, a partial agonist at D2 and D3 receptors." @default.
• W4223550360 created "2022-04-15" @default.
• W4223550360 creator A5066482719 @default.
• W4223550360 creator A5080170915 @default.
• W4223550360 date "2022-05-01" @default.
• W4223550360 modified "2023-09-24" @default.
• W4223550360 title "P 13 Application of antipsychotic drugs in the treatment of schizophrenia according to single nucleotide polymorphisms of risk genes" @default.
• W4223550360 doi "https://doi.org/10.1016/j.clinph.2022.01.044" @default.
• W4223550360 hasPublicationYear "2022" @default.
• W4223550360 type Work @default.
• W4223550360 citedByCount "0" @default.
• W4223550360 crossrefType "journal-article" @default.
• W4223550360 hasAuthorship W4223550360A5066482719 @default.
• W4223550360 hasAuthorship W4223550360A5080170915 @default.
• W4223550360 hasConcept C104317684 @default.
• W4223550360 hasConcept C118552586 @default.
• W4223550360 hasConcept C126322002 @default.
• W4223550360 hasConcept C135763542 @default.
• W4223550360 hasConcept C137183658 @default.
• W4223550360 hasConcept C153209595 @default.
• W4223550360 hasConcept C2776412080 @default.
• W4223550360 hasConcept C2780494398 @default.
• W4223550360 hasConcept C44208683 @default.
• W4223550360 hasConcept C513476851 @default.
• W4223550360 hasConcept C54355233 @default.
• W4223550360 hasConcept C71924100 @default.
• W4223550360 hasConcept C86803240 @default.
• W4223550360 hasConcept C98274493 @default.
• W4223550360 hasConceptScore W4223550360C104317684 @default.
• W4223550360 hasConceptScore W4223550360C118552586 @default.
• W4223550360 hasConceptScore W4223550360C126322002 @default.
• W4223550360 hasConceptScore W4223550360C135763542 @default.
• W4223550360 hasConceptScore W4223550360C137183658 @default.
• W4223550360 hasConceptScore W4223550360C153209595 @default.
• W4223550360 hasConceptScore W4223550360C2776412080 @default.
• W4223550360 hasConceptScore W4223550360C2780494398 @default.
• W4223550360 hasConceptScore W4223550360C44208683 @default.
• W4223550360 hasConceptScore W4223550360C513476851 @default.
• W4223550360 hasConceptScore W4223550360C54355233 @default.
• W4223550360 hasConceptScore W4223550360C71924100 @default.
• W4223550360 hasConceptScore W4223550360C86803240 @default.
• W4223550360 hasConceptScore W4223550360C98274493 @default.
• W4223550360 hasLocation W42235503601 @default.
• W4223550360 hasOpenAccess W4223550360 @default.
• W4223550360 hasPrimaryLocation W42235503601 @default.
• W4223550360 hasRelatedWork W1492008158 @default.
• W4223550360 hasRelatedWork W162304748 @default.
• W4223550360 hasRelatedWork W1982539986 @default.
• W4223550360 hasRelatedWork W2026203247 @default.
• W4223550360 hasRelatedWork W2043111296 @default.
• W4223550360 hasRelatedWork W2068928070 @default.
• W4223550360 hasRelatedWork W2335348223 @default.
• W4223550360 hasRelatedWork W2416699510 @default.
• W4223550360 hasRelatedWork W4205452862 @default.
• W4223550360 hasRelatedWork W4220731823 @default.
• W4223550360 hasVolume "137" @default.
• W4223550360 isParatext "false" @default.
• W4223550360 isRetracted "false" @default.
• W4223550360 workType "article" @default.