FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223554420> ?p ?o ?g. }

• W4223554420 endingPage "325" @default.
• W4223554420 startingPage "313" @default.
• W4223554420 abstract "<b><i>Background and Purpose:</i></b> According to the classical hypothesis, the cerebrospinal fluid (CSF) is actively secreted inside the brain’s ventricular system, predominantly by the choroid plexuses, before flowing unidirectionally in a cranio-caudal orientation toward the arachnoid granulations (AGs), where it is reabsorbed into the dural venous sinuses. This concept has been accepted as a doctrine for more than 100 years and was subjected only to minor modifications. Its inability to provide an adequate explanation to questions arising from the everyday clinical practice, in addition to the ever growing pool of experimental data contradicting it, has led to the identification of its limitations. Literature includes an increasing number of studies suggesting a more complex mechanism than that previously described. This review article summarizes the proposed mechanisms of CSF regulation, referring to the key clinical and experimental developments supporting or defying them. <b><i>Methods:</i></b> A non-systematical literature search of the major databases was performed for studies on the mechanisms of CSF homeostasis. Gray literature was additionally assessed employing a hand-search technique. No restrictions were imposed regarding the time, language, or type of publication. <b><i>Conclusion:</i></b> CSF secretion and absorption are expected to take place throughout the entire brain’s capillaries network under the regulation of hydrostatic and osmotic gradients. The unidirectional flow is defied, highlighting the possibility of its complete absence. The importance of AGs is brought into question, potentiating the significance of the lymphatic system as the primary site of reabsorption. However, the definition of hydrocephalus and its treatment strategies remain strongly associated with the classical hypothesis." @default.
• W4223554420 created "2022-04-15" @default.
• W4223554420 creator A5012285230 @default.
• W4223554420 creator A5027453249 @default.
• W4223554420 creator A5041382679 @default.
• W4223554420 creator A5047209754 @default.
• W4223554420 creator A5063823163 @default.
• W4223554420 creator A5078484503 @default.
• W4223554420 creator A5080997684 @default.
• W4223554420 creator A5081362182 @default.
• W4223554420 date "2022-01-01" @default.
• W4223554420 modified "2023-09-29" @default.
• W4223554420 title "Cerebrospinal Fluid Homeostasis and Hydrodynamics: A Review of Facts and Theories" @default.
• W4223554420 cites W1510306082 @default.
• W4223554420 cites W1514024495 @default.
• W4223554420 cites W1520482882 @default.
• W4223554420 cites W1898796296 @default.
• W4223554420 cites W1948659683 @default.
• W4223554420 cites W1969055275 @default.
• W4223554420 cites W1971250855 @default.
• W4223554420 cites W1973485004 @default.
• W4223554420 cites W1973613551 @default.
• W4223554420 cites W1973638711 @default.
• W4223554420 cites W1975635783 @default.
• W4223554420 cites W1982793350 @default.
• W4223554420 cites W1983030899 @default.
• W4223554420 cites W1983548610 @default.
• W4223554420 cites W1985530741 @default.
• W4223554420 cites W1985637387 @default.
• W4223554420 cites W198948075 @default.
• W4223554420 cites W1991537017 @default.
• W4223554420 cites W1992883702 @default.
• W4223554420 cites W1993041070 @default.
• W4223554420 cites W1993064394 @default.
• W4223554420 cites W1999998811 @default.
• W4223554420 cites W2000907119 @default.
• W4223554420 cites W200532534 @default.
• W4223554420 cites W2005850450 @default.
• W4223554420 cites W2008716142 @default.
• W4223554420 cites W2011760921 @default.
• W4223554420 cites W2017621185 @default.
• W4223554420 cites W2018153775 @default.
• W4223554420 cites W2018995453 @default.
• W4223554420 cites W2019482578 @default.
• W4223554420 cites W2022825458 @default.
• W4223554420 cites W2024720661 @default.
• W4223554420 cites W2026690432 @default.
• W4223554420 cites W2027093787 @default.
• W4223554420 cites W2035476209 @default.
• W4223554420 cites W2036978424 @default.
• W4223554420 cites W2037311401 @default.
• W4223554420 cites W2039499458 @default.
• W4223554420 cites W2041801046 @default.
• W4223554420 cites W2044194688 @default.
• W4223554420 cites W2047100791 @default.
• W4223554420 cites W2058773221 @default.
• W4223554420 cites W2059346073 @default.
• W4223554420 cites W2061294828 @default.
• W4223554420 cites W2063072157 @default.
• W4223554420 cites W2066168767 @default.
• W4223554420 cites W2066344875 @default.
• W4223554420 cites W2069035872 @default.
• W4223554420 cites W2069504119 @default.
• W4223554420 cites W2070298287 @default.
• W4223554420 cites W2071084919 @default.
• W4223554420 cites W2072251236 @default.
• W4223554420 cites W2075749524 @default.
• W4223554420 cites W2077049663 @default.
• W4223554420 cites W2081765246 @default.
• W4223554420 cites W2082363499 @default.
• W4223554420 cites W2083479642 @default.
• W4223554420 cites W2083544490 @default.
• W4223554420 cites W2089464935 @default.
• W4223554420 cites W2092193387 @default.
• W4223554420 cites W2097186175 @default.
• W4223554420 cites W2098157576 @default.
• W4223554420 cites W2100786169 @default.
• W4223554420 cites W2109336197 @default.
• W4223554420 cites W2109459340 @default.
• W4223554420 cites W2110954560 @default.
• W4223554420 cites W2115687133 @default.
• W4223554420 cites W2132382869 @default.
• W4223554420 cites W2137286055 @default.
• W4223554420 cites W2138047090 @default.
• W4223554420 cites W2140420135 @default.
• W4223554420 cites W2144855997 @default.
• W4223554420 cites W2145249424 @default.
• W4223554420 cites W2148901047 @default.
• W4223554420 cites W2149687476 @default.
• W4223554420 cites W2159262826 @default.
• W4223554420 cites W2160939771 @default.
• W4223554420 cites W2163562064 @default.
• W4223554420 cites W2167127477 @default.
• W4223554420 cites W2171263166 @default.
• W4223554420 cites W2193577415 @default.
• W4223554420 cites W2213290267 @default.
• W4223554420 cites W2247922411 @default.
• W4223554420 cites W2263546123 @default.

• next