FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223554426> ?p ?o ?g. }

• W4223554426 abstract "Individuals with chronic kidney disease are affected by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to multiple comorbidities and altered immune system. The first step of the infection process is the binding of SARS-CoV-2 with angiotensin-converting enzyme 2 (ACE2) receptor, followed by its priming by transmembrane protease serine 2 (TMPRSS2). We hypothesized that circulating soluble ACE2 levels, as well as the expressions of ACE2 and TMPRSS2 in the microvasculature, are increased in patients with end-stage kidney disease (ESKD).A total of 210 participants were enrolled, representing 80 ESKD patients and 73 non-CKD controls for soluble ACE2, and 31 ESKD and 26 non-CKD controls for vasculature and fat tissue bioassays. We have assessed ACE2 expression in blood using ELISA and in tissue using immunofluorescence.Soluble ACE2 levels were higher in ESKD patients compared to controls; however, there is no sex difference observed. In ESKD and controls, soluble ACE2 positively correlated with Interleukin 6 (IL-6) and C-reactive protein (CRP), respectively. Similarly, ACE2 tissue expression in the vasculature was higher in ESKD patients; moreover, this higher ACE2 expression was observed only in male ESKD patients. In addition, TMPRSS2 expression was observed in vessels from males and females but showed no sex difference. The expression of ACE2 receptor was higher in ESKD patients on ACE-inhibitor/angiotensin blocker treatment.ESKD is associated with increased ACE2 levels in the circulation and pronounced in male vasculature; however, further studies are warranted to assess possible sex differences on specific treatment regime(s) for different comorbidities present in ESKD." @default.
• W4223554426 created "2022-04-15" @default.
• W4223554426 creator A5011350137 @default.
• W4223554426 creator A5031912470 @default.
• W4223554426 creator A5051045764 @default.
• W4223554426 creator A5052735853 @default.
• W4223554426 creator A5072085702 @default.
• W4223554426 creator A5075064344 @default.
• W4223554426 creator A5087707168 @default.
• W4223554426 date "2022-04-09" @default.
• W4223554426 modified "2023-10-17" @default.
• W4223554426 title "Angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in female and male patients with end‐stage kidney disease" @default.
• W4223554426 cites W1269597682 @default.
• W4223554426 cites W1273733467 @default.
• W4223554426 cites W1681104509 @default.
• W4223554426 cites W1839302738 @default.
• W4223554426 cites W1975426888 @default.
• W4223554426 cites W2002765492 @default.
• W4223554426 cites W2007591654 @default.
• W4223554426 cites W2025672718 @default.
• W4223554426 cites W2039996525 @default.
• W4223554426 cites W2042934449 @default.
• W4223554426 cites W2078084723 @default.
• W4223554426 cites W2122931571 @default.
• W4223554426 cites W2145333723 @default.
• W4223554426 cites W2165971798 @default.
• W4223554426 cites W2167384912 @default.
• W4223554426 cites W2265950305 @default.
• W4223554426 cites W2313849677 @default.
• W4223554426 cites W2337855427 @default.
• W4223554426 cites W2400263775 @default.
• W4223554426 cites W2508390629 @default.
• W4223554426 cites W2611428787 @default.
• W4223554426 cites W2617091728 @default.
• W4223554426 cites W2729700337 @default.
• W4223554426 cites W2736043907 @default.
• W4223554426 cites W2887541779 @default.
• W4223554426 cites W3009723094 @default.
• W4223554426 cites W3010126769 @default.
• W4223554426 cites W3011995143 @default.
• W4223554426 cites W3013302817 @default.
• W4223554426 cites W3013694216 @default.
• W4223554426 cites W3013921190 @default.
• W4223554426 cites W3014541918 @default.
• W4223554426 cites W3014784601 @default.
• W4223554426 cites W3016839066 @default.
• W4223554426 cites W3019773443 @default.
• W4223554426 cites W3022149127 @default.
• W4223554426 cites W3027377573 @default.
• W4223554426 cites W3031390453 @default.
• W4223554426 cites W3042832221 @default.
• W4223554426 cites W3044034817 @default.
• W4223554426 cites W3044069820 @default.
• W4223554426 cites W3044783198 @default.
• W4223554426 cites W3046118641 @default.
• W4223554426 cites W3046170915 @default.
• W4223554426 cites W3046887220 @default.
• W4223554426 cites W3047009938 @default.
• W4223554426 cites W3047267821 @default.
• W4223554426 cites W3047855637 @default.
• W4223554426 cites W3048875944 @default.
• W4223554426 cites W3090997876 @default.
• W4223554426 cites W3091944910 @default.
• W4223554426 cites W3108454226 @default.
• W4223554426 cites W3110738325 @default.
• W4223554426 cites W3113930329 @default.
• W4223554426 cites W3121071822 @default.
• W4223554426 cites W4223554426 @default.
• W4223554426 doi "https://doi.org/10.1111/eci.13786" @default.
• W4223554426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35366343" @default.
• W4223554426 hasPublicationYear "2022" @default.
• W4223554426 type Work @default.
• W4223554426 citedByCount "2" @default.
• W4223554426 countsByYear W42235544262022 @default.
• W4223554426 crossrefType "journal-article" @default.
• W4223554426 hasAuthorship W4223554426A5011350137 @default.
• W4223554426 hasAuthorship W4223554426A5031912470 @default.
• W4223554426 hasAuthorship W4223554426A5051045764 @default.
• W4223554426 hasAuthorship W4223554426A5052735853 @default.
• W4223554426 hasAuthorship W4223554426A5072085702 @default.
• W4223554426 hasAuthorship W4223554426A5075064344 @default.
• W4223554426 hasAuthorship W4223554426A5087707168 @default.
• W4223554426 hasBestOaLocation W42235544261 @default.
• W4223554426 hasConcept C126322002 @default.
• W4223554426 hasConcept C134018914 @default.
• W4223554426 hasConcept C181199279 @default.
• W4223554426 hasConcept C2775946041 @default.
• W4223554426 hasConcept C2776714187 @default.
• W4223554426 hasConcept C2777807008 @default.
• W4223554426 hasConcept C2778042024 @default.
• W4223554426 hasConcept C2778653478 @default.
• W4223554426 hasConcept C2779134260 @default.
• W4223554426 hasConcept C2780091579 @default.
• W4223554426 hasConcept C3008058167 @default.
• W4223554426 hasConcept C524204448 @default.
• W4223554426 hasConcept C55493867 @default.
• W4223554426 hasConcept C71924100 @default.
• W4223554426 hasConcept C86803240 @default.
• W4223554426 hasConceptScore W4223554426C126322002 @default.
• W4223554426 hasConceptScore W4223554426C134018914 @default.

• next