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- W4223555342 endingPage "182" @default.
- W4223555342 startingPage "177" @default.
- W4223555342 abstract "Double stranded DNA (dsDNA) is known to act as a damage-associated molecular pattern (DAMP) that stimulates the body's innate immune response. In general, cyclicGMP-AMP(cGAMP)synthase(cGAS), a DNA sensor, detects these disease-causing DNA and activates the stimulator of interferon gene (STING), which in turn phosphorylates interferon regulatory factor 3 (IRF3), triggering the synthesis of type I interferon (IFN). During this process, the cGAS-STING pathway interacts with different modes of cell death, including autophagy, apoptosis, pyroptosis, and necroptosis. Importantly, cGAS might get stimulated by self-DNA, such as nuclear DNA (nuDNA) and mitochondrial DNA (mtDNA), which ensures a close association between the cGAS-STING signaling pathway and autoimmune responses. Following an ischemic attack, damaged or necrotic cells release large amounts of self-DNA that subsequently activate cGAS, resulting in a range of consequences related to an injury. The present study presents an overview of studies focused on cGAS-STING signaling and cell death, and summarizes the findings of this pathway with regard to ischemia or ischemia/reperfusion (I/R) in different organs of the body, including heart, brain, liver, kidney, and intestine." @default.
- W4223555342 created "2022-04-15" @default.
- W4223555342 creator A5014185434 @default.
- W4223555342 creator A5035298656 @default.
- W4223555342 creator A5066922569 @default.
- W4223555342 creator A5074178064 @default.
- W4223555342 creator A5076857904 @default.
- W4223555342 date "2022-06-01" @default.
- W4223555342 modified "2023-09-30" @default.
- W4223555342 title "cGAS-STING signaling in ischemic diseases" @default.
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