FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223558069> ?p ?o ?g. }

• W4223558069 abstract "Microbial dysbiosis in dental plaque contributes to the occurrence of dental caries, to which Streptococcus mutans is a major contributor. Lactobacillus casei can be used as probiotic therapy to treat caries by replacing S. mutans within the dental plaque. However, the effects of probiotic treatment are not always stable. Oxyresveratrol (ORV), a plant-derived polyphenol, displays opposite effects in that it inhibits cariogenic and promotes commensal bacteria. Thus, the objectives of this study are to investigate the effects of ORV on bacterial proportions in S. mutans-L. casei biofilm and to elucidate how ORV weakens the competitiveness of S. mutans. Quantitative real-time PCR confirms a decreased S. mutans-L. casei ratio in dual-species biofilm by action of ORV. The culture supernatant of L. casei after being incubated with ORV (ORVLC) is prepared to explore the joint action of ORV and L. casei. ORVLC displays the strongest anti-biofilm effect against S. mutans when compared with the effects of L. casei supernatant or ORV alone. As a result of this treatment, both exopolysaccharides and bacteria contents in the biofilm are greatly reduced. The biofilm is transformed from water-insoluble glucan-dominant to water-soluble glucan-dominant by ORVLC through the modulation of the glycometabolism-related genes of S. mutans. As for the interactions between ORV and L. casei, ORV promotes L. casei to produce acetic acid, which provides L. casei with a competitive advantage against S. mutans. Taken together, ORV may be very suitable as an adjuvant medicine for probiotic therapy in the control of dental caries. IMPORTANCE The homeostatic imbalance in dental plaque associated with a sharp increase in the number of cariogenic bacteria such as Streptococcus mutans is critical for the occurrence and development of caries. Probiotic therapy can restore ecological balance by replacing cariogenic pathogens with probiotics. The current study innovatively finds that oxyresveratrol, a natural polyphenol, can provide probiotic Lactobacillus casei with competitive dominance in its dual-species biofilm with S. mutans. The joint action of oxyresveratrol and L. casei strongly inhibits the biofilm formation of S. mutans. Additionally, oxyresveratrol promotes L. casei to produce acetic acid, which facilitates L. casei to compete with S. mutans. Through the effects of these two mechanisms, oxyresveratrol leads to a significantly decreased S. mutans-L. casei ratio in their dual-species biofilm. Thus, oxyresveratrol is speculated to be an ideal medicine for the prevention and treatment of caries by regulating oral flora balance." @default.
• W4223558069 created "2022-04-15" @default.
• W4223558069 creator A5029260248 @default.
• W4223558069 creator A5056699900 @default.
• W4223558069 creator A5057783613 @default.
• W4223558069 creator A5077826535 @default.
• W4223558069 creator A5086050343 @default.
• W4223558069 creator A5089494945 @default.
• W4223558069 date "2022-05-10" @default.
• W4223558069 modified "2023-10-06" @default.
• W4223558069 title "Inhibition of Streptococcus mutans Biofilm Formation by the Joint Action of Oxyresveratrol and Lactobacillus casei" @default.
• W4223558069 cites W1917350117 @default.
• W4223558069 cites W1993749194 @default.
• W4223558069 cites W2007380246 @default.
• W4223558069 cites W2010730839 @default.
• W4223558069 cites W2034492500 @default.
• W4223558069 cites W2049280327 @default.
• W4223558069 cites W2049873923 @default.
• W4223558069 cites W2050006541 @default.
• W4223558069 cites W2058975831 @default.
• W4223558069 cites W2069313647 @default.
• W4223558069 cites W2083181675 @default.
• W4223558069 cites W2089705926 @default.
• W4223558069 cites W2093261208 @default.
• W4223558069 cites W2099832070 @default.
• W4223558069 cites W2103297787 @default.
• W4223558069 cites W2115149585 @default.
• W4223558069 cites W2123937142 @default.
• W4223558069 cites W2131273069 @default.
• W4223558069 cites W2147169580 @default.
• W4223558069 cites W2148369392 @default.
• W4223558069 cites W2151100255 @default.
• W4223558069 cites W2233342056 @default.
• W4223558069 cites W2407907708 @default.
• W4223558069 cites W2564425629 @default.
• W4223558069 cites W2581187823 @default.
• W4223558069 cites W258182121 @default.
• W4223558069 cites W2597674192 @default.
• W4223558069 cites W2598555114 @default.
• W4223558069 cites W2753642535 @default.
• W4223558069 cites W2766396640 @default.
• W4223558069 cites W2783514714 @default.
• W4223558069 cites W2794138542 @default.
• W4223558069 cites W2895999896 @default.
• W4223558069 cites W2910428070 @default.
• W4223558069 cites W2913132188 @default.
• W4223558069 cites W2968634018 @default.
• W4223558069 cites W2970946083 @default.
• W4223558069 cites W3001830125 @default.
• W4223558069 cites W3016842075 @default.
• W4223558069 cites W3033354130 @default.
• W4223558069 cites W3132875858 @default.
• W4223558069 cites W4211107393 @default.
• W4223558069 doi "https://doi.org/10.1128/aem.02436-21" @default.
• W4223558069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35416682" @default.
• W4223558069 hasPublicationYear "2022" @default.
• W4223558069 type Work @default.
• W4223558069 citedByCount "5" @default.
• W4223558069 countsByYear W42235580692022 @default.
• W4223558069 countsByYear W42235580692023 @default.
• W4223558069 crossrefType "journal-article" @default.
• W4223558069 hasAuthorship W4223558069A5029260248 @default.
• W4223558069 hasAuthorship W4223558069A5056699900 @default.
• W4223558069 hasAuthorship W4223558069A5057783613 @default.
• W4223558069 hasAuthorship W4223558069A5077826535 @default.
• W4223558069 hasAuthorship W4223558069A5086050343 @default.
• W4223558069 hasAuthorship W4223558069A5089494945 @default.
• W4223558069 hasBestOaLocation W42235580692 @default.
• W4223558069 hasConcept C100544194 @default.
• W4223558069 hasConcept C185592680 @default.
• W4223558069 hasConcept C2776662696 @default.
• W4223558069 hasConcept C2778430296 @default.
• W4223558069 hasConcept C2779914569 @default.
• W4223558069 hasConcept C2780255968 @default.
• W4223558069 hasConcept C31903555 @default.
• W4223558069 hasConcept C523546767 @default.
• W4223558069 hasConcept C54355233 @default.
• W4223558069 hasConcept C58123911 @default.
• W4223558069 hasConcept C86803240 @default.
• W4223558069 hasConcept C89423630 @default.
• W4223558069 hasConceptScore W4223558069C100544194 @default.
• W4223558069 hasConceptScore W4223558069C185592680 @default.
• W4223558069 hasConceptScore W4223558069C2776662696 @default.
• W4223558069 hasConceptScore W4223558069C2778430296 @default.
• W4223558069 hasConceptScore W4223558069C2779914569 @default.
• W4223558069 hasConceptScore W4223558069C2780255968 @default.
• W4223558069 hasConceptScore W4223558069C31903555 @default.
• W4223558069 hasConceptScore W4223558069C523546767 @default.
• W4223558069 hasConceptScore W4223558069C54355233 @default.
• W4223558069 hasConceptScore W4223558069C58123911 @default.
• W4223558069 hasConceptScore W4223558069C86803240 @default.
• W4223558069 hasConceptScore W4223558069C89423630 @default.
• W4223558069 hasFunder F4320321001 @default.
• W4223558069 hasIssue "9" @default.
• W4223558069 hasLocation W42235580691 @default.
• W4223558069 hasLocation W42235580692 @default.
• W4223558069 hasLocation W42235580693 @default.
• W4223558069 hasOpenAccess W4223558069 @default.
• W4223558069 hasPrimaryLocation W42235580691 @default.
• W4223558069 hasRelatedWork W1483059914 @default.

• next