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• W4223566150 endingPage "232" @default.
• W4223566150 startingPage "232" @default.
• W4223566150 abstract "Simple, timely, and precise detection of SARS-CoV-2 in clinical samples and contaminated surfaces aids in lowering attendant morbidity/mortality related to this infectious virus. Currently applied diagnostic techniques depend on a timely laboratory report following PCR testing. However, the application of these tests is associated with inherent shortcomings due to the need for trained personnel, long-time centralized laboratories, and expensive instruments. Therefore, there is an interest in developing biosensing diagnostic frontiers that can help in eliminating these shortcomings with a relatively economical, easy-to-use, well-timed, precise and sensitive technology. This study reports the development of fabricated Q-tips designed to qualitatively and semi-quantitatively detect SARS-CoV-2 in clinical samples and contaminated non-absorbable surfaces. This colorimetric sensor is engineered to sandwich SARS-CoV-2 spike protein between the lactoferrin general capturing agent and the complementary ACE2-labeled receptor. The ACE2 receptor is decorated with an orange-colored polymeric nanoparticle to generate an optical visual signal upon pairing with the SARS-CoV-2 spike protein. This colorimetric change of the Q-tip testing zone from white to orange confirms a positive result. The visual detection limit of the COVID-19 engineered colorimetric Q-tip sensor was 100 pfu/mL within a relatively short turnaround time of 5 min. The linear working range of quantitation was 103-108 pfu/mL. The engineered sensor selectively targeted SARS-CoV-2 spike protein and did not bind to another coronavirus such as MERS-CoV, Flu A, or Flu B present on the contaminated surface. This novel detection tool is relatively cheap to produce and suitable for onsite detection of COVID-19 infection." @default.
• W4223566150 created "2022-04-15" @default.
• W4223566150 creator A5027198187 @default.
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• W4223566150 date "2022-04-11" @default.
• W4223566150 modified "2023-10-03" @default.
• W4223566150 title "A Portable Nanoprobe for Rapid and Sensitive Detection of SARS-CoV-2 S1 Protein" @default.
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• W4223566150 doi "https://doi.org/10.3390/bios12040232" @default.
• W4223566150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35448292" @default.
• W4223566150 hasPublicationYear "2022" @default.
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