FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223582144> ?p ?o ?g. }

• W4223582144 abstract "The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT enzyme removes O6-methylguanine (O6-meG) lesions. In the setting of MGMT-promoter methylation (MGMT-), the O6-meG lesion activates the mismatch repair (MMR) pathway which functions to remove the damage. Our group reported that loss of MGMT expression via MGMT promoter silencing modulates activation of ataxia telangiectasia and RAD3 related protein (ATR) in response to TMZ treatment, which is associated with synergistic tumor-cell killing. Whether or not MMR proteins are involved in ATR activation in MGMT-cells upon alkylation damage remains poorly understood. To investigate the function of MMR in ATR activation, we created isogenic cell lines with knockdowns of the individual human MMR proteins MutS homolog 2 (MSH2), MutS homolog 6 (MSH6), MutS homolog 3 (MSH3), MutL homolog 1 (MLH1), and PMS1 homolog 2 (PMS2). Here, we demonstrate that MSH2, MSH6, MLH1 and PMS2, specifically, are involved in the activation of the ATR axis after TMZ exposure, whereas MSH3 is likely not. This study elucidates a potential mechanistic understanding of how the MMR system is involved in ATR activation by TMZ in glioblastoma cells, which is important for targeting MMR-mutated cancers." @default.
• W4223582144 created "2022-04-15" @default.
• W4223582144 creator A5010473969 @default.
• W4223582144 creator A5016318219 @default.
• W4223582144 creator A5020861985 @default.
• W4223582144 creator A5040738951 @default.
• W4223582144 date "2022-04-06" @default.
• W4223582144 modified "2023-09-30" @default.
• W4223582144 title "Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma" @default.
• W4223582144 cites W111616551 @default.
• W4223582144 cites W1647238192 @default.
• W4223582144 cites W1863440278 @default.
• W4223582144 cites W1872551000 @default.
• W4223582144 cites W1882634342 @default.
• W4223582144 cites W1900816255 @default.
• W4223582144 cites W1981142961 @default.
• W4223582144 cites W1982276380 @default.
• W4223582144 cites W2008466187 @default.
• W4223582144 cites W2016175366 @default.
• W4223582144 cites W2025183726 @default.
• W4223582144 cites W2037898576 @default.
• W4223582144 cites W2037916186 @default.
• W4223582144 cites W2038663019 @default.
• W4223582144 cites W2055315999 @default.
• W4223582144 cites W2055993339 @default.
• W4223582144 cites W2076141569 @default.
• W4223582144 cites W2085315842 @default.
• W4223582144 cites W2087261504 @default.
• W4223582144 cites W2094390470 @default.
• W4223582144 cites W2096576375 @default.
• W4223582144 cites W2097478662 @default.
• W4223582144 cites W2104633297 @default.
• W4223582144 cites W2105100844 @default.
• W4223582144 cites W2106816824 @default.
• W4223582144 cites W2106952961 @default.
• W4223582144 cites W2111403239 @default.
• W4223582144 cites W2113613085 @default.
• W4223582144 cites W2118731052 @default.
• W4223582144 cites W2129133898 @default.
• W4223582144 cites W2136431054 @default.
• W4223582144 cites W2137655134 @default.
• W4223582144 cites W2138521081 @default.
• W4223582144 cites W2153980875 @default.
• W4223582144 cites W2163529853 @default.
• W4223582144 cites W2344726805 @default.
• W4223582144 cites W2584114288 @default.
• W4223582144 cites W2612326755 @default.
• W4223582144 cites W2792896330 @default.
• W4223582144 cites W2899144445 @default.
• W4223582144 cites W2931932810 @default.
• W4223582144 cites W2955082801 @default.
• W4223582144 cites W2987858617 @default.
• W4223582144 cites W3162010243 @default.
• W4223582144 cites W3166434609 @default.
• W4223582144 doi "https://doi.org/10.1038/s41598-022-09614-x" @default.
• W4223582144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35388070" @default.
• W4223582144 hasPublicationYear "2022" @default.
• W4223582144 type Work @default.
• W4223582144 citedByCount "5" @default.
• W4223582144 countsByYear W42235821442022 @default.
• W4223582144 countsByYear W42235821442023 @default.
• W4223582144 crossrefType "journal-article" @default.
• W4223582144 hasAuthorship W4223582144A5010473969 @default.
• W4223582144 hasAuthorship W4223582144A5016318219 @default.
• W4223582144 hasAuthorship W4223582144A5020861985 @default.
• W4223582144 hasAuthorship W4223582144A5040738951 @default.
• W4223582144 hasBestOaLocation W42235821441 @default.
• W4223582144 hasConcept C104317684 @default.
• W4223582144 hasConcept C111425858 @default.
• W4223582144 hasConcept C134935766 @default.
• W4223582144 hasConcept C2776674815 @default.
• W4223582144 hasConcept C2777389519 @default.
• W4223582144 hasConcept C2778227246 @default.
• W4223582144 hasConcept C2778677574 @default.
• W4223582144 hasConcept C2779115348 @default.
• W4223582144 hasConcept C2779527866 @default.
• W4223582144 hasConcept C33288867 @default.
• W4223582144 hasConcept C502942594 @default.
• W4223582144 hasConcept C54355233 @default.
• W4223582144 hasConcept C60748783 @default.
• W4223582144 hasConcept C86803240 @default.
• W4223582144 hasConcept C91965660 @default.
• W4223582144 hasConceptScore W4223582144C104317684 @default.
• W4223582144 hasConceptScore W4223582144C111425858 @default.
• W4223582144 hasConceptScore W4223582144C134935766 @default.
• W4223582144 hasConceptScore W4223582144C2776674815 @default.
• W4223582144 hasConceptScore W4223582144C2777389519 @default.
• W4223582144 hasConceptScore W4223582144C2778227246 @default.
• W4223582144 hasConceptScore W4223582144C2778677574 @default.
• W4223582144 hasConceptScore W4223582144C2779115348 @default.
• W4223582144 hasConceptScore W4223582144C2779527866 @default.
• W4223582144 hasConceptScore W4223582144C33288867 @default.
• W4223582144 hasConceptScore W4223582144C502942594 @default.
• W4223582144 hasConceptScore W4223582144C54355233 @default.
• W4223582144 hasConceptScore W4223582144C60748783 @default.
• W4223582144 hasConceptScore W4223582144C86803240 @default.
• W4223582144 hasConceptScore W4223582144C91965660 @default.
• W4223582144 hasFunder F4320306631 @default.
• W4223582144 hasFunder F4320332161 @default.
• W4223582144 hasIssue "1" @default.

• next